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Recent Updates of Lipoprotein(a) and Cardiovascular Disease

In recent years, epidemiological studies, genome-wide association studies, and Mendelian randomization studies have shown a strong association between increased levels of lipoproteins and increased risks of coronary heart disease and cardiovascular disease (CVD). Although lipoprotein(a) [Lp(a)] was...

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Autores principales: Liu, Taili, Yoon, Won-Sik, Lee, Sang-Rok
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Chonnam National University Medical School 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7840349/
https://www.ncbi.nlm.nih.gov/pubmed/33537217
http://dx.doi.org/10.4068/cmj.2021.57.1.36
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author Liu, Taili
Yoon, Won-Sik
Lee, Sang-Rok
author_facet Liu, Taili
Yoon, Won-Sik
Lee, Sang-Rok
author_sort Liu, Taili
collection PubMed
description In recent years, epidemiological studies, genome-wide association studies, and Mendelian randomization studies have shown a strong association between increased levels of lipoproteins and increased risks of coronary heart disease and cardiovascular disease (CVD). Although lipoprotein(a) [Lp(a)] was an independent risk factor for ASCVD, the latest international clinical guidelines do not recommend direct reduction of plasma Lp(a) concentrations. The main reason was that there is no effective clinical medicine that directly lowers plasma Lp(a) concentrations. However, recent clinical trials have shown that proprotein convertase subtilisin/kexin-type 9 inhibitors (PCSK9) and second-generation antisense oligonucleotides can effectively reduce plasma Lp(a) levels. This review will present the structure, pathogenicity, prognostic evidences, and recent advances in therapeutic drugs for Lp(a).
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spelling pubmed-78403492021-02-02 Recent Updates of Lipoprotein(a) and Cardiovascular Disease Liu, Taili Yoon, Won-Sik Lee, Sang-Rok Chonnam Med J Review Article In recent years, epidemiological studies, genome-wide association studies, and Mendelian randomization studies have shown a strong association between increased levels of lipoproteins and increased risks of coronary heart disease and cardiovascular disease (CVD). Although lipoprotein(a) [Lp(a)] was an independent risk factor for ASCVD, the latest international clinical guidelines do not recommend direct reduction of plasma Lp(a) concentrations. The main reason was that there is no effective clinical medicine that directly lowers plasma Lp(a) concentrations. However, recent clinical trials have shown that proprotein convertase subtilisin/kexin-type 9 inhibitors (PCSK9) and second-generation antisense oligonucleotides can effectively reduce plasma Lp(a) levels. This review will present the structure, pathogenicity, prognostic evidences, and recent advances in therapeutic drugs for Lp(a). Chonnam National University Medical School 2021-01 2021-01-25 /pmc/articles/PMC7840349/ /pubmed/33537217 http://dx.doi.org/10.4068/cmj.2021.57.1.36 Text en © Chonnam Medical Journal, 2021 http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Liu, Taili
Yoon, Won-Sik
Lee, Sang-Rok
Recent Updates of Lipoprotein(a) and Cardiovascular Disease
title Recent Updates of Lipoprotein(a) and Cardiovascular Disease
title_full Recent Updates of Lipoprotein(a) and Cardiovascular Disease
title_fullStr Recent Updates of Lipoprotein(a) and Cardiovascular Disease
title_full_unstemmed Recent Updates of Lipoprotein(a) and Cardiovascular Disease
title_short Recent Updates of Lipoprotein(a) and Cardiovascular Disease
title_sort recent updates of lipoprotein(a) and cardiovascular disease
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7840349/
https://www.ncbi.nlm.nih.gov/pubmed/33537217
http://dx.doi.org/10.4068/cmj.2021.57.1.36
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