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Liposomes: Biomedical Applications
Liposomes, with their flexible physicochemical and biophysical properties, continue to be studied as an important potential a critical drug delivery system. Liposomes have overcome the challenges of conventional free drug therapy by encapsulating therapeutic agents, thereby improving in vivo biodist...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Chonnam National University Medical School
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7840352/ https://www.ncbi.nlm.nih.gov/pubmed/33537216 http://dx.doi.org/10.4068/cmj.2021.57.1.27 |
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author | Kim, Eun-Mi Jeong, Hwan-Jeong |
author_facet | Kim, Eun-Mi Jeong, Hwan-Jeong |
author_sort | Kim, Eun-Mi |
collection | PubMed |
description | Liposomes, with their flexible physicochemical and biophysical properties, continue to be studied as an important potential a critical drug delivery system. Liposomes have overcome the challenges of conventional free drug therapy by encapsulating therapeutic agents, thereby improving in vivo biodistribution and reducing systemic toxicity. New imaging modalities and interpretation techniques, as well as new techniques for targetable system formulation technique, and tumor environmental information, have affected the search for a means of overcoming the difficulties of conventional liposome formulation. In this review, we briefly discuss how liposomal formulation has been applied across the biomedical field, particularly as a therapy, and the role it may play in the future, when paired with new developments in diagnosis and theranostics. The biological challenges that still remain and the translational obstacles are discussed. |
format | Online Article Text |
id | pubmed-7840352 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Chonnam National University Medical School |
record_format | MEDLINE/PubMed |
spelling | pubmed-78403522021-02-02 Liposomes: Biomedical Applications Kim, Eun-Mi Jeong, Hwan-Jeong Chonnam Med J Review Article Liposomes, with their flexible physicochemical and biophysical properties, continue to be studied as an important potential a critical drug delivery system. Liposomes have overcome the challenges of conventional free drug therapy by encapsulating therapeutic agents, thereby improving in vivo biodistribution and reducing systemic toxicity. New imaging modalities and interpretation techniques, as well as new techniques for targetable system formulation technique, and tumor environmental information, have affected the search for a means of overcoming the difficulties of conventional liposome formulation. In this review, we briefly discuss how liposomal formulation has been applied across the biomedical field, particularly as a therapy, and the role it may play in the future, when paired with new developments in diagnosis and theranostics. The biological challenges that still remain and the translational obstacles are discussed. Chonnam National University Medical School 2021-01 2021-01-25 /pmc/articles/PMC7840352/ /pubmed/33537216 http://dx.doi.org/10.4068/cmj.2021.57.1.27 Text en © Chonnam Medical Journal, 2021 http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Kim, Eun-Mi Jeong, Hwan-Jeong Liposomes: Biomedical Applications |
title | Liposomes: Biomedical Applications |
title_full | Liposomes: Biomedical Applications |
title_fullStr | Liposomes: Biomedical Applications |
title_full_unstemmed | Liposomes: Biomedical Applications |
title_short | Liposomes: Biomedical Applications |
title_sort | liposomes: biomedical applications |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7840352/ https://www.ncbi.nlm.nih.gov/pubmed/33537216 http://dx.doi.org/10.4068/cmj.2021.57.1.27 |
work_keys_str_mv | AT kimeunmi liposomesbiomedicalapplications AT jeonghwanjeong liposomesbiomedicalapplications |