Cargando…

Liposomes: Biomedical Applications

Liposomes, with their flexible physicochemical and biophysical properties, continue to be studied as an important potential a critical drug delivery system. Liposomes have overcome the challenges of conventional free drug therapy by encapsulating therapeutic agents, thereby improving in vivo biodist...

Descripción completa

Detalles Bibliográficos
Autores principales: Kim, Eun-Mi, Jeong, Hwan-Jeong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Chonnam National University Medical School 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7840352/
https://www.ncbi.nlm.nih.gov/pubmed/33537216
http://dx.doi.org/10.4068/cmj.2021.57.1.27
_version_ 1783643562610524160
author Kim, Eun-Mi
Jeong, Hwan-Jeong
author_facet Kim, Eun-Mi
Jeong, Hwan-Jeong
author_sort Kim, Eun-Mi
collection PubMed
description Liposomes, with their flexible physicochemical and biophysical properties, continue to be studied as an important potential a critical drug delivery system. Liposomes have overcome the challenges of conventional free drug therapy by encapsulating therapeutic agents, thereby improving in vivo biodistribution and reducing systemic toxicity. New imaging modalities and interpretation techniques, as well as new techniques for targetable system formulation technique, and tumor environmental information, have affected the search for a means of overcoming the difficulties of conventional liposome formulation. In this review, we briefly discuss how liposomal formulation has been applied across the biomedical field, particularly as a therapy, and the role it may play in the future, when paired with new developments in diagnosis and theranostics. The biological challenges that still remain and the translational obstacles are discussed.
format Online
Article
Text
id pubmed-7840352
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Chonnam National University Medical School
record_format MEDLINE/PubMed
spelling pubmed-78403522021-02-02 Liposomes: Biomedical Applications Kim, Eun-Mi Jeong, Hwan-Jeong Chonnam Med J Review Article Liposomes, with their flexible physicochemical and biophysical properties, continue to be studied as an important potential a critical drug delivery system. Liposomes have overcome the challenges of conventional free drug therapy by encapsulating therapeutic agents, thereby improving in vivo biodistribution and reducing systemic toxicity. New imaging modalities and interpretation techniques, as well as new techniques for targetable system formulation technique, and tumor environmental information, have affected the search for a means of overcoming the difficulties of conventional liposome formulation. In this review, we briefly discuss how liposomal formulation has been applied across the biomedical field, particularly as a therapy, and the role it may play in the future, when paired with new developments in diagnosis and theranostics. The biological challenges that still remain and the translational obstacles are discussed. Chonnam National University Medical School 2021-01 2021-01-25 /pmc/articles/PMC7840352/ /pubmed/33537216 http://dx.doi.org/10.4068/cmj.2021.57.1.27 Text en © Chonnam Medical Journal, 2021 http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Kim, Eun-Mi
Jeong, Hwan-Jeong
Liposomes: Biomedical Applications
title Liposomes: Biomedical Applications
title_full Liposomes: Biomedical Applications
title_fullStr Liposomes: Biomedical Applications
title_full_unstemmed Liposomes: Biomedical Applications
title_short Liposomes: Biomedical Applications
title_sort liposomes: biomedical applications
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7840352/
https://www.ncbi.nlm.nih.gov/pubmed/33537216
http://dx.doi.org/10.4068/cmj.2021.57.1.27
work_keys_str_mv AT kimeunmi liposomesbiomedicalapplications
AT jeonghwanjeong liposomesbiomedicalapplications