Arginase 1 Insufficiency Precipitates Amyloid-β Deposition and Hastens Behavioral Impairment in a Mouse Model of Amyloidosis

Alzheimer’s disease (AD) includes several hallmarks comprised of amyloid-β (Aβ) deposition, tau neuropathology, inflammation, and memory impairment. Brain metabolism becomes uncoupled due to aging and other AD risk factors, which ultimately lead to impaired protein clearance and aggregation. Increas...

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Detalles Bibliográficos
Autores principales: Ma, Chao, Hunt, Jerry B., Selenica, Maj-Linda B., Sanneh, Awa, Sandusky-Beltran, Leslie A., Watler, Mallory, Daas, Rana, Kovalenko, Andrii, Liang, Huimin, Placides, Devon, Cao, Chuanhai, Lin, Xiaoyang, Orr, Michael B., Zhang, Bei, Gensel, John C., Feola, David J., Gordon, Marcia N., Morgan, Dave, Bickford, Paula C., Lee, Daniel C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7840571/
https://www.ncbi.nlm.nih.gov/pubmed/33519806
http://dx.doi.org/10.3389/fimmu.2020.582998

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7840571/
https://www.ncbi.nlm.nih.gov/pubmed/33519806
http://dx.doi.org/10.3389/fimmu.2020.582998

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