TALEN outperforms Cas9 in editing heterochromatin target sites

Genome editing critically relies on selective recognition of target sites. However, despite recent progress, the underlying search mechanism of genome-editing proteins is not fully understood in the context of cellular chromatin environments. Here, we use single-molecule imaging in live cells to dir...

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Detalles Bibliográficos
Autores principales: Jain, Surbhi, Shukla, Saurabh, Yang, Che, Zhang, Meng, Fatma, Zia, Lingamaneni, Manasi, Abesteh, Shireen, Lane, Stephan Thomas, Xiong, Xiong, Wang, Yuchuan, Schroeder, Charles M., Selvin, Paul R., Zhao, Huimin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7840734/
https://www.ncbi.nlm.nih.gov/pubmed/33504770
http://dx.doi.org/10.1038/s41467-020-20672-5

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