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Overexpression of miR-140 Inhibits Proliferation of Osteosarcoma Cells via Suppression of Histone Deacetylase 4

miRNAs play a pivotal role in the development and progression of osteosarcoma (OS). Previous studies indicated that miR-140 acts as a tumor suppressor in many cancers. However, its accurate expression and exact function in OS cells remain unknown. Herein, we demonstrated the lower expression of miR-...

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Autores principales: Xiao, Qianren, Huang, Lu, Zhang, Zhongzu, Chen, Xiang, Luo, Jiaquan, Zhang, Zhanmin, Chen, Shaoqing, Shu, Yong, Han, Zhimin, Cao, Kai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cognizant Communication Corporation 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7840736/
https://www.ncbi.nlm.nih.gov/pubmed/27624383
http://dx.doi.org/10.3727/096504016X14732510786564
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author Xiao, Qianren
Huang, Lu
Zhang, Zhongzu
Chen, Xiang
Luo, Jiaquan
Zhang, Zhanmin
Chen, Shaoqing
Shu, Yong
Han, Zhimin
Cao, Kai
author_facet Xiao, Qianren
Huang, Lu
Zhang, Zhongzu
Chen, Xiang
Luo, Jiaquan
Zhang, Zhanmin
Chen, Shaoqing
Shu, Yong
Han, Zhimin
Cao, Kai
author_sort Xiao, Qianren
collection PubMed
description miRNAs play a pivotal role in the development and progression of osteosarcoma (OS). Previous studies indicated that miR-140 acts as a tumor suppressor in many cancers. However, its accurate expression and exact function in OS cells remain unknown. Herein, we demonstrated the lower expression of miR-140 in 40 paired OS tissues. Restoring miR-140 expression in OS cells had a marked effect on inhibiting cell proliferation and invasion, inducing cell apoptosis in vitro, and suppressing tumor growth in vivo. Moreover, a bioinformatics prediction indicated that the histone deacetylase 4 (HDAC4) is a target gene of miR-140 and is involved in miR-140-mediated suppressive effects. In conclusion, our findings show that miR-140 acts as a tumor suppressor in OS by targeting HDAC4.
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spelling pubmed-78407362021-02-16 Overexpression of miR-140 Inhibits Proliferation of Osteosarcoma Cells via Suppression of Histone Deacetylase 4 Xiao, Qianren Huang, Lu Zhang, Zhongzu Chen, Xiang Luo, Jiaquan Zhang, Zhanmin Chen, Shaoqing Shu, Yong Han, Zhimin Cao, Kai Oncol Res Article miRNAs play a pivotal role in the development and progression of osteosarcoma (OS). Previous studies indicated that miR-140 acts as a tumor suppressor in many cancers. However, its accurate expression and exact function in OS cells remain unknown. Herein, we demonstrated the lower expression of miR-140 in 40 paired OS tissues. Restoring miR-140 expression in OS cells had a marked effect on inhibiting cell proliferation and invasion, inducing cell apoptosis in vitro, and suppressing tumor growth in vivo. Moreover, a bioinformatics prediction indicated that the histone deacetylase 4 (HDAC4) is a target gene of miR-140 and is involved in miR-140-mediated suppressive effects. In conclusion, our findings show that miR-140 acts as a tumor suppressor in OS by targeting HDAC4. Cognizant Communication Corporation 2017-01-26 /pmc/articles/PMC7840736/ /pubmed/27624383 http://dx.doi.org/10.3727/096504016X14732510786564 Text en Copyright © 2017 Cognizant, LLC. http://creativecommons.org/licenses/by-nc-nd/4.0/ This article is licensed under a Creative Commons Attribution-NonCommercial NoDerivatives 4.0 International License.
spellingShingle Article
Xiao, Qianren
Huang, Lu
Zhang, Zhongzu
Chen, Xiang
Luo, Jiaquan
Zhang, Zhanmin
Chen, Shaoqing
Shu, Yong
Han, Zhimin
Cao, Kai
Overexpression of miR-140 Inhibits Proliferation of Osteosarcoma Cells via Suppression of Histone Deacetylase 4
title Overexpression of miR-140 Inhibits Proliferation of Osteosarcoma Cells via Suppression of Histone Deacetylase 4
title_full Overexpression of miR-140 Inhibits Proliferation of Osteosarcoma Cells via Suppression of Histone Deacetylase 4
title_fullStr Overexpression of miR-140 Inhibits Proliferation of Osteosarcoma Cells via Suppression of Histone Deacetylase 4
title_full_unstemmed Overexpression of miR-140 Inhibits Proliferation of Osteosarcoma Cells via Suppression of Histone Deacetylase 4
title_short Overexpression of miR-140 Inhibits Proliferation of Osteosarcoma Cells via Suppression of Histone Deacetylase 4
title_sort overexpression of mir-140 inhibits proliferation of osteosarcoma cells via suppression of histone deacetylase 4
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7840736/
https://www.ncbi.nlm.nih.gov/pubmed/27624383
http://dx.doi.org/10.3727/096504016X14732510786564
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