Cargando…
Overexpression of miR-140 Inhibits Proliferation of Osteosarcoma Cells via Suppression of Histone Deacetylase 4
miRNAs play a pivotal role in the development and progression of osteosarcoma (OS). Previous studies indicated that miR-140 acts as a tumor suppressor in many cancers. However, its accurate expression and exact function in OS cells remain unknown. Herein, we demonstrated the lower expression of miR-...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cognizant Communication Corporation
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7840736/ https://www.ncbi.nlm.nih.gov/pubmed/27624383 http://dx.doi.org/10.3727/096504016X14732510786564 |
_version_ | 1783643639617945600 |
---|---|
author | Xiao, Qianren Huang, Lu Zhang, Zhongzu Chen, Xiang Luo, Jiaquan Zhang, Zhanmin Chen, Shaoqing Shu, Yong Han, Zhimin Cao, Kai |
author_facet | Xiao, Qianren Huang, Lu Zhang, Zhongzu Chen, Xiang Luo, Jiaquan Zhang, Zhanmin Chen, Shaoqing Shu, Yong Han, Zhimin Cao, Kai |
author_sort | Xiao, Qianren |
collection | PubMed |
description | miRNAs play a pivotal role in the development and progression of osteosarcoma (OS). Previous studies indicated that miR-140 acts as a tumor suppressor in many cancers. However, its accurate expression and exact function in OS cells remain unknown. Herein, we demonstrated the lower expression of miR-140 in 40 paired OS tissues. Restoring miR-140 expression in OS cells had a marked effect on inhibiting cell proliferation and invasion, inducing cell apoptosis in vitro, and suppressing tumor growth in vivo. Moreover, a bioinformatics prediction indicated that the histone deacetylase 4 (HDAC4) is a target gene of miR-140 and is involved in miR-140-mediated suppressive effects. In conclusion, our findings show that miR-140 acts as a tumor suppressor in OS by targeting HDAC4. |
format | Online Article Text |
id | pubmed-7840736 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Cognizant Communication Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-78407362021-02-16 Overexpression of miR-140 Inhibits Proliferation of Osteosarcoma Cells via Suppression of Histone Deacetylase 4 Xiao, Qianren Huang, Lu Zhang, Zhongzu Chen, Xiang Luo, Jiaquan Zhang, Zhanmin Chen, Shaoqing Shu, Yong Han, Zhimin Cao, Kai Oncol Res Article miRNAs play a pivotal role in the development and progression of osteosarcoma (OS). Previous studies indicated that miR-140 acts as a tumor suppressor in many cancers. However, its accurate expression and exact function in OS cells remain unknown. Herein, we demonstrated the lower expression of miR-140 in 40 paired OS tissues. Restoring miR-140 expression in OS cells had a marked effect on inhibiting cell proliferation and invasion, inducing cell apoptosis in vitro, and suppressing tumor growth in vivo. Moreover, a bioinformatics prediction indicated that the histone deacetylase 4 (HDAC4) is a target gene of miR-140 and is involved in miR-140-mediated suppressive effects. In conclusion, our findings show that miR-140 acts as a tumor suppressor in OS by targeting HDAC4. Cognizant Communication Corporation 2017-01-26 /pmc/articles/PMC7840736/ /pubmed/27624383 http://dx.doi.org/10.3727/096504016X14732510786564 Text en Copyright © 2017 Cognizant, LLC. http://creativecommons.org/licenses/by-nc-nd/4.0/ This article is licensed under a Creative Commons Attribution-NonCommercial NoDerivatives 4.0 International License. |
spellingShingle | Article Xiao, Qianren Huang, Lu Zhang, Zhongzu Chen, Xiang Luo, Jiaquan Zhang, Zhanmin Chen, Shaoqing Shu, Yong Han, Zhimin Cao, Kai Overexpression of miR-140 Inhibits Proliferation of Osteosarcoma Cells via Suppression of Histone Deacetylase 4 |
title | Overexpression of miR-140 Inhibits Proliferation of Osteosarcoma Cells via Suppression of Histone Deacetylase 4 |
title_full | Overexpression of miR-140 Inhibits Proliferation of Osteosarcoma Cells via Suppression of Histone Deacetylase 4 |
title_fullStr | Overexpression of miR-140 Inhibits Proliferation of Osteosarcoma Cells via Suppression of Histone Deacetylase 4 |
title_full_unstemmed | Overexpression of miR-140 Inhibits Proliferation of Osteosarcoma Cells via Suppression of Histone Deacetylase 4 |
title_short | Overexpression of miR-140 Inhibits Proliferation of Osteosarcoma Cells via Suppression of Histone Deacetylase 4 |
title_sort | overexpression of mir-140 inhibits proliferation of osteosarcoma cells via suppression of histone deacetylase 4 |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7840736/ https://www.ncbi.nlm.nih.gov/pubmed/27624383 http://dx.doi.org/10.3727/096504016X14732510786564 |
work_keys_str_mv | AT xiaoqianren overexpressionofmir140inhibitsproliferationofosteosarcomacellsviasuppressionofhistonedeacetylase4 AT huanglu overexpressionofmir140inhibitsproliferationofosteosarcomacellsviasuppressionofhistonedeacetylase4 AT zhangzhongzu overexpressionofmir140inhibitsproliferationofosteosarcomacellsviasuppressionofhistonedeacetylase4 AT chenxiang overexpressionofmir140inhibitsproliferationofosteosarcomacellsviasuppressionofhistonedeacetylase4 AT luojiaquan overexpressionofmir140inhibitsproliferationofosteosarcomacellsviasuppressionofhistonedeacetylase4 AT zhangzhanmin overexpressionofmir140inhibitsproliferationofosteosarcomacellsviasuppressionofhistonedeacetylase4 AT chenshaoqing overexpressionofmir140inhibitsproliferationofosteosarcomacellsviasuppressionofhistonedeacetylase4 AT shuyong overexpressionofmir140inhibitsproliferationofosteosarcomacellsviasuppressionofhistonedeacetylase4 AT hanzhimin overexpressionofmir140inhibitsproliferationofosteosarcomacellsviasuppressionofhistonedeacetylase4 AT caokai overexpressionofmir140inhibitsproliferationofosteosarcomacellsviasuppressionofhistonedeacetylase4 |