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Total IgE as a Marker for Chronic Spontaneous Urticaria
OBJECTIVE: Immunoglobulin E (IgE) and its receptor, FcɛRI, importantly contribute to the pathophysiology of chronic spontaneous urticaria (CSU). Recent findings point to a possible role of total IgE as a marker of CSU disease activity, endotypes, and responses to treatment. The evidence in support o...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Academy of Asthma, Allergy and Clinical Immunology; The Korean Academy of Pediatric Allergy and Respiratory Disease
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7840871/ https://www.ncbi.nlm.nih.gov/pubmed/33474856 http://dx.doi.org/10.4168/aair.2021.13.2.206 |
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author | Altrichter, Sabine Fok, Jie Shen Jiao, Qingqing Kolkhir, Pavel Pyatilova, Polina Romero, Sherezade Moñino Scheffel, Jörg Siebenhaar, Frank Steinert, Carolin Terhorst-Molawi, Dorothea Xiang, Yi-Kui Church, Martin K Maurer, Marcus |
author_facet | Altrichter, Sabine Fok, Jie Shen Jiao, Qingqing Kolkhir, Pavel Pyatilova, Polina Romero, Sherezade Moñino Scheffel, Jörg Siebenhaar, Frank Steinert, Carolin Terhorst-Molawi, Dorothea Xiang, Yi-Kui Church, Martin K Maurer, Marcus |
author_sort | Altrichter, Sabine |
collection | PubMed |
description | OBJECTIVE: Immunoglobulin E (IgE) and its receptor, FcɛRI, importantly contribute to the pathophysiology of chronic spontaneous urticaria (CSU). Recent findings point to a possible role of total IgE as a marker of CSU disease activity, endotypes, and responses to treatment. The evidence in support of total IgE included in the diagnostic workup of patients with CSU has not yet been reviewed. METHODS: Publications were searched via PubMed. The search terms used were “chronic urticaria” and “total IgE.” Studies were screened by titles and abstracts, and 141 were used in the review. RESULTS: CSU patients frequently had elevated total IgE serum levels (up to 50%), but normal or very low total IgE levels also occurred. High total IgE may represent high disease activity, longer disease duration, high chance of responding to omalizumab treatment, quick relapse after stopping omalizumab, and lower chance of responding to cyclosporine. Low IgE, in contrast, may suggest Type IIb autoimmune CSU, poor response to treatment with omalizumab and a better chance to benefits from cyclosporine treatment. Furthermore, IgE in different CSU cohorts may have different physicochemical properties that could explain differences in treatment responses to IgE-directed therapies. CONCLUSION: The results of our review suggest that total IgE is a valuable marker for CSU, and we recommend its assessment in the routine diagnostic workup of CSU patients. |
format | Online Article Text |
id | pubmed-7840871 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | The Korean Academy of Asthma, Allergy and Clinical Immunology; The Korean Academy of Pediatric Allergy and Respiratory Disease |
record_format | MEDLINE/PubMed |
spelling | pubmed-78408712021-03-01 Total IgE as a Marker for Chronic Spontaneous Urticaria Altrichter, Sabine Fok, Jie Shen Jiao, Qingqing Kolkhir, Pavel Pyatilova, Polina Romero, Sherezade Moñino Scheffel, Jörg Siebenhaar, Frank Steinert, Carolin Terhorst-Molawi, Dorothea Xiang, Yi-Kui Church, Martin K Maurer, Marcus Allergy Asthma Immunol Res Review OBJECTIVE: Immunoglobulin E (IgE) and its receptor, FcɛRI, importantly contribute to the pathophysiology of chronic spontaneous urticaria (CSU). Recent findings point to a possible role of total IgE as a marker of CSU disease activity, endotypes, and responses to treatment. The evidence in support of total IgE included in the diagnostic workup of patients with CSU has not yet been reviewed. METHODS: Publications were searched via PubMed. The search terms used were “chronic urticaria” and “total IgE.” Studies were screened by titles and abstracts, and 141 were used in the review. RESULTS: CSU patients frequently had elevated total IgE serum levels (up to 50%), but normal or very low total IgE levels also occurred. High total IgE may represent high disease activity, longer disease duration, high chance of responding to omalizumab treatment, quick relapse after stopping omalizumab, and lower chance of responding to cyclosporine. Low IgE, in contrast, may suggest Type IIb autoimmune CSU, poor response to treatment with omalizumab and a better chance to benefits from cyclosporine treatment. Furthermore, IgE in different CSU cohorts may have different physicochemical properties that could explain differences in treatment responses to IgE-directed therapies. CONCLUSION: The results of our review suggest that total IgE is a valuable marker for CSU, and we recommend its assessment in the routine diagnostic workup of CSU patients. The Korean Academy of Asthma, Allergy and Clinical Immunology; The Korean Academy of Pediatric Allergy and Respiratory Disease 2021-01-04 /pmc/articles/PMC7840871/ /pubmed/33474856 http://dx.doi.org/10.4168/aair.2021.13.2.206 Text en Copyright © 2021 The Korean Academy of Asthma, Allergy and Clinical Immunology • The Korean Academy of Pediatric Allergy and Respiratory Disease https://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Altrichter, Sabine Fok, Jie Shen Jiao, Qingqing Kolkhir, Pavel Pyatilova, Polina Romero, Sherezade Moñino Scheffel, Jörg Siebenhaar, Frank Steinert, Carolin Terhorst-Molawi, Dorothea Xiang, Yi-Kui Church, Martin K Maurer, Marcus Total IgE as a Marker for Chronic Spontaneous Urticaria |
title | Total IgE as a Marker for Chronic Spontaneous Urticaria |
title_full | Total IgE as a Marker for Chronic Spontaneous Urticaria |
title_fullStr | Total IgE as a Marker for Chronic Spontaneous Urticaria |
title_full_unstemmed | Total IgE as a Marker for Chronic Spontaneous Urticaria |
title_short | Total IgE as a Marker for Chronic Spontaneous Urticaria |
title_sort | total ige as a marker for chronic spontaneous urticaria |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7840871/ https://www.ncbi.nlm.nih.gov/pubmed/33474856 http://dx.doi.org/10.4168/aair.2021.13.2.206 |
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