Murine liver repair via transient activation of regenerative pathways in hepatocytes using lipid nanoparticle-complexed nucleoside-modified mRNA

Induction of intrinsic liver regeneration is an unmet need that can be achieved by temporally activating key hepatocyte regenerative pathways. Here, we establish an efficient, safe, non-integrative method to transiently express hepatocyte-growth-factor (HGF) and epidermal-growth-factor (EGF) in hepa...

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Detalles Bibliográficos
Autores principales: Rizvi, Fatima, Everton, Elissa, Smith, Anna R., Liu, Hua, Osota, Elizabeth, Beattie, Mitchell, Tam, Ying, Pardi, Norbert, Weissman, Drew, Gouon-Evans, Valerie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7840919/
https://www.ncbi.nlm.nih.gov/pubmed/33504774
http://dx.doi.org/10.1038/s41467-021-20903-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7840919/
https://www.ncbi.nlm.nih.gov/pubmed/33504774
http://dx.doi.org/10.1038/s41467-021-20903-3

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