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Depletion of Survivin suppresses docetaxel-induced apoptosis in HeLa cells by facilitating mitotic slippage

The anticancer effects of taxanes are attributed to the induction of mitotic arrest through activation of the spindle assembly checkpoint. Cell death following extended mitotic arrest is mediated by the intrinsic apoptosis pathway. Accordingly, factors that influence the robustness of mitotic arrest...

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Detalles Bibliográficos
Autores principales:	Han, Teng-Long, Sha, Hang, Ji, Jun, Li, Yun-Tian, Wu, Deng-Shan, Lin, Hu, Hu, Bin, Jiang, Zhi-Xin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7840972/ https://www.ncbi.nlm.nih.gov/pubmed/33504817 http://dx.doi.org/10.1038/s41598-021-81563-3

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