Cargando…

Inhibitors of PI3K/ERK1/2/p38 MAPK Show Preferential Activity Against Endocrine-Resistant Breast Cancer Cells

Current mainstream pharmacological options for the treatment of endocrine-resistant breast cancer have limitations in terms of their side effect profile and lack of discrimination between normal and cancer cells. In the current study, we assessed the responses of normal breast epithelial cells MCF10...

Descripción completa

Detalles Bibliográficos
Autores principales:	Khajah, Maitham A., Mathew, Princy M., Luqmani, Yunus A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cognizant Communication Corporation 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7841054/ https://www.ncbi.nlm.nih.gov/pubmed/28276317 http://dx.doi.org/10.3727/096504017X14883245308282

Ejemplares similares

Na(+)/K(+) ATPase activity promotes invasion of endocrine resistant breast cancer cells
por: Khajah, Maitham A., et al.
Publicado: (2018)

Extracellular Alkaline pH Leads to Increased Metastatic Potential of Estrogen Receptor Silenced Endocrine Resistant Breast Cancer Cells
por: Khajah, Maitham A., et al.
Publicado: (2013)

Differential Effect of Growth Factors on Invasion and Proliferation of Endocrine Resistant Breast Cancer Cells
por: Khajah, Maitham A., et al.
Publicado: (2012)

MicroRNA expression profiling of endocrine sensitive and resistant breast cancer cell lines
por: Khajah, Maitham A., et al.
Publicado: (2022)

Hypoxic environment may enhance migration/penetration of endocrine resistant MCF7- derived breast cancer cells through monolayers of other non-invasive cancer cells in vitro
por: Barrak, Nora H., et al.
Publicado: (2020)

Involvement of Membrane Blebbing in Immunological Disorders and Cancer
por: Khajah, Maitham A., et al.
Publicado: (2016)

Blockade of voltage-gated sodium channels inhibits invasion of endocrine-resistant breast cancer cells
por: MOHAMMED, FATIMA H., et al.
Publicado: (2015)

Lactate Dehydrogenase A or B Knockdown Reduces Lactate Production and Inhibits Breast Cancer Cell Motility in vitro
por: Khajah, Maitham A., et al.
Publicado: (2021)

Glucose deprivation reduces proliferation and motility, and enhances the anti-proliferative effects of paclitaxel and doxorubicin in breast cell lines in vitro
por: Khajah, Maitham A., et al.
Publicado: (2022)

Anti-Inflammatory Action of Angiotensin 1-7 in Experimental Colitis
por: Khajah, Maitham A., et al.
Publicado: (2016)

Leptin Inhibits Glucose Intestinal Absorption via PKC, p38MAPK, PI3K and MEK/ERK
por: El-Zein, Ola, et al.
Publicado: (2013)

Hesperetin Inhibits Vascular Formation by Suppressing of the PI3K/AKT, ERK, and p38 MAPK Signaling Pathways
por: Kim, Gi Dae
Publicado: (2014)

α7 nicotinic acetylcholine receptor interaction with G proteins in breast cancer cell proliferation, motility, and calcium signaling
por: Oz, Murat, et al.
Publicado: (2023)

Src-dependent EGFR transactivation regulates lung inflammation via downstream signaling involving ERK1/2, PI3Kδ/Akt and NFκB induction in a murine asthma model
por: El-Hashim, Ahmed Z., et al.
Publicado: (2017)

Assessment of Tracer (99m)Tc(V)-DMSA Uptake as a Measure of Tumor Cell Proliferation In Vitro
por: Al-Saeedi, Fatma J., et al.
Publicado: (2013)

Simvastatin Preferentially Targets FLT3/ITD Acute Myeloid Leukemia by Inhibiting MEK/ERK and p38-MAPK Signaling Pathways
por: Li, Genhong, et al.
Publicado: (2023)

p38MAPK, ERK and PI3K Signaling Pathways Are Involved in C5a-Primed Neutrophils for ANCA-Mediated Activation
por: Hao, Jian, et al.
Publicado: (2012)

Erianin suppresses hepatocellular carcinoma cells through down-regulation of PI3K/AKT, p38 and ERK MAPK signaling pathways
por: Yang, Liang, et al.
Publicado: (2020)

Fucoidan Induces Apoptosis and Inhibits Proliferation of Hepatocellular Carcinoma via the p38 MAPK/ERK and PI3K/Akt Signal Pathways
por: Duan, Yifei, et al.
Publicado: (2020)

Overcoming Resistance to Endocrine Therapy in Breast Cancer: New Approaches to a Nagging Problem
por: Luqmani, Yunus A., et al.
Publicado: (2016)

Differential Effects of p38, MAPK, PI3K or Rho Kinase Inhibitors on Bacterial Phagocytosis and Efferocytosis by Macrophages in COPD
por: Bewley, Martin A., et al.
Publicado: (2016)

Effect of minocycline, methyl prednisolone, or combination treatment on the colonic bacterial population in a state of colonic inflammation using the murine dextran sulfate sodium model
por: Khajah, Maitham A., et al.
Publicado: (2023)

ERK1/2 and p38 MAPKs Are Complementarily Involved in Estradiol 17ß-d-Glucuronide-Induced Cholestasis: Crosstalk with cPKC and PI3K
por: Boaglio, Andrea C., et al.
Publicado: (2012)

p38 MAPK and PI3K/AKT Signalling Cascades inParkinson’s Disease
por: Jha, Saurabh Kumar, et al.
Publicado: (2015)

Phosphorylation of PI3K/Akt and MAPK/ERK in an early entry step of enterovirus 71
por: Wong, Wen-Rou, et al.
Publicado: (2005)

Onion Bulb Extract Downregulates EGFR/ERK1/2/AKT Signaling Pathway and Synergizes With Steroids to Inhibit Allergic Inflammation
por: El-Hashim, Ahmed Z., et al.
Publicado: (2020)

Biological characterization of SN32976, a selective inhibitor of PI3K and mTOR with preferential activity to PI3Kα, in comparison to established pan PI3K inhibitors
por: Rewcastle, Gordon W, et al.
Publicado: (2017)

β-Caryophyllene, a CB2-Receptor-Selective Phytocannabinoid, Suppresses Mechanical Allodynia in a Mouse Model of Antiretroviral-Induced Neuropathic Pain
por: Aly, Esraa, et al.
Publicado: (2019)

Upregulation of Salmonella-Induced IL-6 Production in Caco-2 Cells by PJ-34, PARP-1 Inhibitor: Involvement of PI3K, p38 MAPK, ERK, JNK, and NF-κB
por: Huang, Fu-Chen
Publicado: (2009)

RNA-binding proteins as a point of convergence of the PI3K and p38 MAPK pathways
por: Venigalla, Ram K. C., et al.
Publicado: (2012)

The Roles of PI3K/AKT/mTOR and MAPK/ERK Signaling Pathways in Human Pheochromocytomas
por: Du, Juan, et al.
Publicado: (2016)

Effects of evodiamine on PI3K/Akt and MAPK/ERK signaling pathways in pancreatic cancer cells
por: Hong, Zhong, et al.
Publicado: (2020)

Synergistic targeting of the PI3K/mTOR and MAPK/ERK pathways in Merkel cell carcinoma
por: Temblador, Arturo, et al.
Publicado: (2022)

Aluminum Nanoparticles Induce ERK and p38MAPK Activation in Rat Brain
por: Kwon, Jung-Taek, et al.
Publicado: (2013)

Lupeol, a Pentacyclic Triterpene, Promotes Migration, Wound Closure, and Contractile Effect In Vitro: Possible Involvement of PI3K/Akt and p38/ERK/MAPK Pathways
por: Pereira Beserra, Fernando, et al.
Publicado: (2018)

The PI3K and MAPK/p38 pathways control stress granule assembly in a hierarchical manner
por: Heberle, Alexander Martin, et al.
Publicado: (2019)

Cannabidiol‐mediated RISK PI3K/AKT and MAPK/ERK pathways decreasing reperfusion myocardial damage
por: Franco‐Vadillo, Antonio, et al.
Publicado: (2021)

Anti-Inflammatory Properties of the Enaminone E121 in the Dextran Sulfate Sodium (DSS) Colitis Model
por: Khajah, Maitham A., et al.
Publicado: (2016)

Blockade of 67-kDa Laminin Receptor Facilitates AQP4 Down-Regulation and BBB Disruption via ERK1/2-and p38 MAPK-Mediated PI3K/AKT Activations
por: Kim, Ji-Eun, et al.
Publicado: (2020)

Crosstalk Between MAPK/ERK and PI3K/AKT Signal Pathways During Brain Ischemia/Reperfusion
por: Zhou, Jing, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_o3hl2tcmdb43i8me99sk90ukbl