Cargando…
Protease Serine S1 Family Member 8 (PRSS8) Inhibits Tumor Growth In Vitro and In Vivo in Human Non-Small Cell Lung Cancer
Protease serine S1 family member 8 (PRSS8), a membrane-anchored serine protease, has been reported to be involved in the development of several human cancers. However, the role of PRSS8 in non-small cell lung cancer (NSCLC) pathogenesis remains unclear. The objective of this study was to investigate...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cognizant Communication Corporation
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7841066/ https://www.ncbi.nlm.nih.gov/pubmed/27983914 http://dx.doi.org/10.3727/096504016X14772417575982 |
_version_ | 1783643719168163840 |
---|---|
author | Ma, Chaonan Ma, Wei Zhou, Nannan Chen, Na An, Li Zhang, Yijie |
author_facet | Ma, Chaonan Ma, Wei Zhou, Nannan Chen, Na An, Li Zhang, Yijie |
author_sort | Ma, Chaonan |
collection | PubMed |
description | Protease serine S1 family member 8 (PRSS8), a membrane-anchored serine protease, has been reported to be involved in the development of several human cancers. However, the role of PRSS8 in non-small cell lung cancer (NSCLC) pathogenesis remains unclear. The objective of this study was to investigate PRSS8 expression, biological function, and its related molecular mechanism in NSCLC. Our results showed that PRSS8 was expressed in a low amount in NSCLC cell lines. Ectopic expression of PRSS8 inhibited tumor growth in vitro and in vivo. Furthermore, ectopic expression of PRSS8 inhibited the migration and invasion of NSCLC cells. It also suppressed the EMT process in A549 cells. Mechanistically, we found that the ectopic expression of PRSS8 downregulated the protein expression levels of p-JAK1, p-JAK2, and p-STAT3 in A549 cells. Taken together, our study showed that PRSS8 plays an important role in the growth and metastasis of NSCLC. Thus, PRSS8 may be a novel therapeutic target for NSCLC. |
format | Online Article Text |
id | pubmed-7841066 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Cognizant Communication Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-78410662021-02-16 Protease Serine S1 Family Member 8 (PRSS8) Inhibits Tumor Growth In Vitro and In Vivo in Human Non-Small Cell Lung Cancer Ma, Chaonan Ma, Wei Zhou, Nannan Chen, Na An, Li Zhang, Yijie Oncol Res Article Protease serine S1 family member 8 (PRSS8), a membrane-anchored serine protease, has been reported to be involved in the development of several human cancers. However, the role of PRSS8 in non-small cell lung cancer (NSCLC) pathogenesis remains unclear. The objective of this study was to investigate PRSS8 expression, biological function, and its related molecular mechanism in NSCLC. Our results showed that PRSS8 was expressed in a low amount in NSCLC cell lines. Ectopic expression of PRSS8 inhibited tumor growth in vitro and in vivo. Furthermore, ectopic expression of PRSS8 inhibited the migration and invasion of NSCLC cells. It also suppressed the EMT process in A549 cells. Mechanistically, we found that the ectopic expression of PRSS8 downregulated the protein expression levels of p-JAK1, p-JAK2, and p-STAT3 in A549 cells. Taken together, our study showed that PRSS8 plays an important role in the growth and metastasis of NSCLC. Thus, PRSS8 may be a novel therapeutic target for NSCLC. Cognizant Communication Corporation 2017-05-24 /pmc/articles/PMC7841066/ /pubmed/27983914 http://dx.doi.org/10.3727/096504016X14772417575982 Text en Copyright © 2017 Cognizant, LLC. http://creativecommons.org/licenses/by-nc-nd/4.0/ This article is licensed under a Creative Commons Attribution-NonCommercial NoDerivatives 4.0 International License. |
spellingShingle | Article Ma, Chaonan Ma, Wei Zhou, Nannan Chen, Na An, Li Zhang, Yijie Protease Serine S1 Family Member 8 (PRSS8) Inhibits Tumor Growth In Vitro and In Vivo in Human Non-Small Cell Lung Cancer |
title | Protease Serine S1 Family Member 8 (PRSS8) Inhibits Tumor Growth In Vitro and In Vivo in Human Non-Small Cell Lung Cancer |
title_full | Protease Serine S1 Family Member 8 (PRSS8) Inhibits Tumor Growth In Vitro and In Vivo in Human Non-Small Cell Lung Cancer |
title_fullStr | Protease Serine S1 Family Member 8 (PRSS8) Inhibits Tumor Growth In Vitro and In Vivo in Human Non-Small Cell Lung Cancer |
title_full_unstemmed | Protease Serine S1 Family Member 8 (PRSS8) Inhibits Tumor Growth In Vitro and In Vivo in Human Non-Small Cell Lung Cancer |
title_short | Protease Serine S1 Family Member 8 (PRSS8) Inhibits Tumor Growth In Vitro and In Vivo in Human Non-Small Cell Lung Cancer |
title_sort | protease serine s1 family member 8 (prss8) inhibits tumor growth in vitro and in vivo in human non-small cell lung cancer |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7841066/ https://www.ncbi.nlm.nih.gov/pubmed/27983914 http://dx.doi.org/10.3727/096504016X14772417575982 |
work_keys_str_mv | AT machaonan proteaseserines1familymember8prss8inhibitstumorgrowthinvitroandinvivoinhumannonsmallcelllungcancer AT mawei proteaseserines1familymember8prss8inhibitstumorgrowthinvitroandinvivoinhumannonsmallcelllungcancer AT zhounannan proteaseserines1familymember8prss8inhibitstumorgrowthinvitroandinvivoinhumannonsmallcelllungcancer AT chenna proteaseserines1familymember8prss8inhibitstumorgrowthinvitroandinvivoinhumannonsmallcelllungcancer AT anli proteaseserines1familymember8prss8inhibitstumorgrowthinvitroandinvivoinhumannonsmallcelllungcancer AT zhangyijie proteaseserines1familymember8prss8inhibitstumorgrowthinvitroandinvivoinhumannonsmallcelllungcancer |