Identification of Chalcone Derivatives as Inhibitors of Leishmania infantum Arginase and Promising Antileishmanial Agents

Arginase catalyzes the hydrolysis of l-arginine into l-ornithine and urea, acting as a key enzyme in the biosynthesis of polyamines. Leishmania growth and survival is dependent on polyamine biosynthesis; therefore, inhibition of Leishmania arginase may be a promising therapeutic strategy. Here, we e...

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Detalles Bibliográficos
Autores principales: Garcia, Andreza R., Oliveira, Danielle M. P., Jesus, Jessica B., Souza, Alessandra M. T., Sodero, Ana Carolina R., Vermelho, Alane B., Leal, Ivana C. R., Souza, Rodrigo Octavio M. A., Miranda, Leandro S. M., Pinheiro, Anderson S., Rodrigues, Igor A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7841069/
https://www.ncbi.nlm.nih.gov/pubmed/33520939
http://dx.doi.org/10.3389/fchem.2020.624678

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