Cargando…

Overexpression of RAS-Association Domain Family 6 (RASSF6) Inhibits Proliferation and Tumorigenesis in Hepatocellular Carcinoma Cells

Ras-association domain family 6 (RASSF6), a member of the RASSF family, is frequently downregulated in various types of cancer. However, the roles of RASSF6 in human hepatocellular carcinoma (HCC) are still unclear. In this study, we investigated the biological functions and related molecular mechan...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhu, Nan, Si, Mahui, Yang, Ning, Jing, Yingying, Fu, Yong, Zhao, Xijun, Lin, Zhipeng, Yang, Guangshun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cognizant Communication Corporation 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7841125/ https://www.ncbi.nlm.nih.gov/pubmed/27983932 http://dx.doi.org/10.3727/096504016X14796039599926

Ejemplares similares

Downregulation of Ras Association Domain Family Member 6 (RASSF6) Underlies the Treatment Resistance of Highly Metastatic Nasopharyngeal Carcinoma Cells
por: Liang, Ying-Ying, et al.
Publicado: (2014)

The Ras-association domain family (RASSF) members and their role in human tumourigenesis
por: van der Weyden, Louise, et al.
Publicado: (2007)

RASSF6; the Putative Tumor Suppressor of the RASSF Family
por: Iwasa, Hiroaki, et al.
Publicado: (2015)

The RASSF gene family members RASSF5, RASSF6 and RASSF7 show frequent DNA methylation in neuroblastoma
por: Djos, Anna, et al.
Publicado: (2012)

The RASSF1 Gene and the Opposing Effects of the RASSF1A and RASSF1C Isoforms on Cell Proliferation and Apoptosis
por: Reeves, Mark E., et al.
Publicado: (2013)

RASSF4 Overexpression Inhibits the Proliferation, Invasion, EMT, and Wnt Signaling Pathway in Osteosarcoma Cells
por: Zhang, Minglei, et al.
Publicado: (2017)

The novel RASSF6 and RASSF10 candidate tumour suppressor genes are frequently epigenetically inactivated in childhood leukaemias
por: Hesson, Luke B, et al.
Publicado: (2009)

Silencing of RASSF3 by DNA Hypermethylation Is Associated with Tumorigenesis in Somatotroph Adenomas
por: Peng, Hu, et al.
Publicado: (2013)

RASSF6 Expression in Adipocytes Is Down-Regulated by Interaction with Macrophages
por: Sanada, Yohei, et al.
Publicado: (2013)

TAK1 Phosphorylates RASSF9 and Inhibits Esophageal Squamous Tumor Cell Proliferation by Targeting the RAS/MEK/ERK Axis
por: Shi, Hui, et al.
Publicado: (2021)

The tumour suppressor Ras-association domain family protein 1A (RASSF1A) regulates TNF-α signalling in cardiomyocytes
por: Mohamed, Tamer M.A., et al.
Publicado: (2014)

The RASSF1A Tumor Suppressor Binds the RasGAP DAB2IP and Modulates RAS Activation in Lung Cancer
por: Harrell Stewart, Desmond R., et al.
Publicado: (2020)

RASSF1A, puppeteer of cellular homeostasis, fights tumorigenesis, and metastasis—an updated review
por: Dubois, Fatéméh, et al.
Publicado: (2019)

Loss of RASSF1A Expression in Colorectal Cancer and Its Association with K-ras Status
por: Cao, Dan, et al.
Publicado: (2013)

Overexpression of SIRT6 attenuates the tumorigenicity of hepatocellular carcinoma cells
por: Wang, Yadong, et al.
Publicado: (2017)

SARAH Domain-Mediated MST2-RASSF Dimeric Interactions
por: Sánchez-Sanz, Goar, et al.
Publicado: (2016)

Activating Hippo Pathway via Rassf1 by Ursolic Acid Suppresses the Tumorigenesis of Gastric Cancer
por: Kim, Seong-Hun, et al.
Publicado: (2019)

Identification of RASSF1A promoter hypermethylation as a biomarker for hepatocellular carcinoma
por: Xu, Gang, et al.
Publicado: (2020)

RASSF9 promotes NSCLC cell proliferation by activating the MEK/ERK axis
por: Yuan, Jun, et al.
Publicado: (2021)

Decreased level of RASSF6 in sporadic colorectal cancer and its anti-tumor effects both in vitro and in vivo
por: Chen, Erfei, et al.
Publicado: (2016)

RASSF10 suppresses hepatocellular carcinoma growth by activating P53 signaling and methylation of RASSF10 is a docetaxel resistant marker
por: Jin, Yongshuai, et al.
Publicado: (2015)

Overexpressed Galectin-3 in Pancreatic Cancer Induces Cell Proliferation and Invasion by Binding Ras and Activating Ras Signaling
por: Song, Shumei, et al.
Publicado: (2012)

The SARAH Domain of RASSF1A and Its Tumor Suppressor Function
por: Dittfeld, Claudia, et al.
Publicado: (2012)

RASSF1A methylation as a biomarker for detection of colorectal cancer and hepatocellular carcinoma
por: Li, Jian, et al.
Publicado: (2022)

Methylation associated inactivation of RASSF1A and its synergistic effect with activated K-Ras in nasopharyngeal carcinoma
por: Wang, Tao, et al.
Publicado: (2009)

Pathogenetic and Prognostic Significance of Inactivation of RASSF Proteins in Human Hepatocellular Carcinoma
por: Calvisi, Diego F., et al.
Publicado: (2012)

Long non-coding RNA CCAT2 functions as an oncogene in hepatocellular carcinoma, regulating cellular proliferation, migration and apoptosis
por: ZHOU, NING, et al.
Publicado: (2016)

TET1 inhibits cell proliferation by inducing RASSF5 expression
por: Li, Bo-Tai, et al.
Publicado: (2017)

NLRP1 Overexpression Is Correlated with the Tumorigenesis and Proliferation of Human Breast Tumor
por: Wei, Yuxian, et al.
Publicado: (2017)

Overexpression of ST5, an activator of Ras, has no effect on β-cell proliferation in adult mice
por: Ou, Kristy, et al.
Publicado: (2018)

RASSF6 downregulation promotes the epithelial-mesenchymal transition and predicts poor prognosis in colorectal cancer
por: Zhou, Rui, et al.
Publicado: (2017)

The Association of RAS Association Domain Family Protein1A (RASSF1A) Methylation States and Bladder Cancer Risk: A Systematic Review and Meta-Analysis
por: Gao, Tianyi, et al.
Publicado: (2012)

RASSF Family Proteins
por: Clark, Geoffrey J., et al.
Publicado: (2012)

m6A modification on the fate of colorectal cancer: functions and mechanisms of cell proliferation and tumorigenesis
por: Jiang, Xiaohan, et al.
Publicado: (2023)

FXYD6 overexpression in HBV-related hepatocellular carcinoma with cirrhosis
por: Chen, Xiongfei, et al.
Publicado: (2020)

Engineered variants of the Ras effector protein RASSF5 (NORE1A) promote anticancer activities in lung adenocarcinoma
por: Singh, Anamika, et al.
Publicado: (2021)

Structural basis of the heterodimerization of the MST and RASSF SARAH domains in the Hippo signalling pathway
por: Hwang, Eunha, et al.
Publicado: (2014)

Suppressor of hepatocellular carcinoma RASSF1A activates autophagy initiation and maturation
por: Li, Wenjiao, et al.
Publicado: (2018)

Polymorphisms of the Ras-Association Domain Family 1 Isoform A (RASSF1A) Gene are Associated with Ovarian Cancer, and with the Prognostic Factors of Grade and Stage, in Women in Southern China
por: He, Wei, et al.
Publicado: (2018)

lncRNA TUSC7 inhibits osteosarcoma progression through the miR-181a/RASSF6 axis
por: Zhao, Aiqing, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_5ucjn4efd1v8on0arbspkjh2ch