Overexpression of PER3 Inhibits Self-Renewal Capability and Chemoresistance of Colorectal Cancer Stem-Like Cells via Inhibition of Notch and β-Catenin Signaling

PER3, a circadian clock gene, plays an important role in colorectal cancer, but its action and underlying mechanism in colorectal cancer stem-like cells (CSCs) remain unclear. In this study, the colorectal CSCs were enriched in colorectal HCT-116 sphere-forming cells, expressing lower levels of stem...

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Detalles Bibliográficos
Autores principales: Zhang, Feng, Sun, Hong, Zhang, Sai, Yang, Xin, Zhang, Guogang, Su, Tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cognizant Communication Corporation 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7841129/
https://www.ncbi.nlm.nih.gov/pubmed/27983919
http://dx.doi.org/10.3727/096504016X14772331883976

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7841129/
https://www.ncbi.nlm.nih.gov/pubmed/27983919
http://dx.doi.org/10.3727/096504016X14772331883976

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