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Arsenic exposure in Indo Gangetic plains of Bihar causing increased cancer risk

Reportedly, 300 million people worldwide are affected by the consumption of arsenic contaminated groundwater. India prominently figures amongst them and the state of Bihar has shown an upsurge in cases affected by arsenic poisoning. Escalated arsenic content in blood, leaves 1 in every 100 human bei...

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Autores principales: Kumar, Arun, Ali, Mohammad, Kumar, Ranjit, Kumar, Mukesh, Sagar, Prity, Pandey, Ritu Kumari, Akhouri, Vivek, Kumar, Vikas, Anand, Gautam, Niraj, Pintoo Kumar, Rani, Rita, Kumar, Santosh, Kumar, Dhruv, Bishwapriya, Akhouri, Ghosh, Ashok Kumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7841152/
https://www.ncbi.nlm.nih.gov/pubmed/33504854
http://dx.doi.org/10.1038/s41598-021-81579-9
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author Kumar, Arun
Ali, Mohammad
Kumar, Ranjit
Kumar, Mukesh
Sagar, Prity
Pandey, Ritu Kumari
Akhouri, Vivek
Kumar, Vikas
Anand, Gautam
Niraj, Pintoo Kumar
Rani, Rita
Kumar, Santosh
Kumar, Dhruv
Bishwapriya, Akhouri
Ghosh, Ashok Kumar
author_facet Kumar, Arun
Ali, Mohammad
Kumar, Ranjit
Kumar, Mukesh
Sagar, Prity
Pandey, Ritu Kumari
Akhouri, Vivek
Kumar, Vikas
Anand, Gautam
Niraj, Pintoo Kumar
Rani, Rita
Kumar, Santosh
Kumar, Dhruv
Bishwapriya, Akhouri
Ghosh, Ashok Kumar
author_sort Kumar, Arun
collection PubMed
description Reportedly, 300 million people worldwide are affected by the consumption of arsenic contaminated groundwater. India prominently figures amongst them and the state of Bihar has shown an upsurge in cases affected by arsenic poisoning. Escalated arsenic content in blood, leaves 1 in every 100 human being highly vulnerable to being affected by the disease. Uncontrolled intake may lead to skin, kidney, liver, bladder, or lung related cancer but even indirect forms of cancer are showing up on a regular basis with abnormal arsenic levels as the probable cause. But despite the apparent relation, the etiology has not been understood clearly. Blood samples of 2000 confirmed cancer patients were collected from pathology department of our institute. For cross-sectional design, 200 blood samples of subjects free from cancer from arsenic free pockets of Patna urban agglomeration, were collected. Blood arsenic levels in carcinoma patients as compared to sarcomas, lymphomas and leukemia were found to be higher. The geospatial map correlates the blood arsenic with cancer types and the demographic area of Gangetic plains. Most of the cancer patients with high blood arsenic concentration were from the districts near the river Ganges. The raised blood arsenic concentration in the 2000 cancer patients strongly correlates the relationship of arsenic with cancer especially the carcinoma type which is more vulnerable. The average arsenic concentration in blood of the cancer patients in the Gangetic plains denotes the significant role of arsenic which is present in endemic proportions. Thus, the study significantly correlates and advocates a strong relation of the deleterious element with the disease. It also underlines the need to address the problem by deciphering the root cause of the elevated cancer incidences in the Gangetic basin of Bihar and its association with arsenic poisoning.
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spelling pubmed-78411522021-01-29 Arsenic exposure in Indo Gangetic plains of Bihar causing increased cancer risk Kumar, Arun Ali, Mohammad Kumar, Ranjit Kumar, Mukesh Sagar, Prity Pandey, Ritu Kumari Akhouri, Vivek Kumar, Vikas Anand, Gautam Niraj, Pintoo Kumar Rani, Rita Kumar, Santosh Kumar, Dhruv Bishwapriya, Akhouri Ghosh, Ashok Kumar Sci Rep Article Reportedly, 300 million people worldwide are affected by the consumption of arsenic contaminated groundwater. India prominently figures amongst them and the state of Bihar has shown an upsurge in cases affected by arsenic poisoning. Escalated arsenic content in blood, leaves 1 in every 100 human being highly vulnerable to being affected by the disease. Uncontrolled intake may lead to skin, kidney, liver, bladder, or lung related cancer but even indirect forms of cancer are showing up on a regular basis with abnormal arsenic levels as the probable cause. But despite the apparent relation, the etiology has not been understood clearly. Blood samples of 2000 confirmed cancer patients were collected from pathology department of our institute. For cross-sectional design, 200 blood samples of subjects free from cancer from arsenic free pockets of Patna urban agglomeration, were collected. Blood arsenic levels in carcinoma patients as compared to sarcomas, lymphomas and leukemia were found to be higher. The geospatial map correlates the blood arsenic with cancer types and the demographic area of Gangetic plains. Most of the cancer patients with high blood arsenic concentration were from the districts near the river Ganges. The raised blood arsenic concentration in the 2000 cancer patients strongly correlates the relationship of arsenic with cancer especially the carcinoma type which is more vulnerable. The average arsenic concentration in blood of the cancer patients in the Gangetic plains denotes the significant role of arsenic which is present in endemic proportions. Thus, the study significantly correlates and advocates a strong relation of the deleterious element with the disease. It also underlines the need to address the problem by deciphering the root cause of the elevated cancer incidences in the Gangetic basin of Bihar and its association with arsenic poisoning. Nature Publishing Group UK 2021-01-27 /pmc/articles/PMC7841152/ /pubmed/33504854 http://dx.doi.org/10.1038/s41598-021-81579-9 Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Kumar, Arun
Ali, Mohammad
Kumar, Ranjit
Kumar, Mukesh
Sagar, Prity
Pandey, Ritu Kumari
Akhouri, Vivek
Kumar, Vikas
Anand, Gautam
Niraj, Pintoo Kumar
Rani, Rita
Kumar, Santosh
Kumar, Dhruv
Bishwapriya, Akhouri
Ghosh, Ashok Kumar
Arsenic exposure in Indo Gangetic plains of Bihar causing increased cancer risk
title Arsenic exposure in Indo Gangetic plains of Bihar causing increased cancer risk
title_full Arsenic exposure in Indo Gangetic plains of Bihar causing increased cancer risk
title_fullStr Arsenic exposure in Indo Gangetic plains of Bihar causing increased cancer risk
title_full_unstemmed Arsenic exposure in Indo Gangetic plains of Bihar causing increased cancer risk
title_short Arsenic exposure in Indo Gangetic plains of Bihar causing increased cancer risk
title_sort arsenic exposure in indo gangetic plains of bihar causing increased cancer risk
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7841152/
https://www.ncbi.nlm.nih.gov/pubmed/33504854
http://dx.doi.org/10.1038/s41598-021-81579-9
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