Cargando…

The Inhibitory Effects of HYDAMTIQ, a Novel PARP Inhibitor, on Growth in Human Tumor Cell Lines With Defective DNA Damage Response Pathways

The poly(ADP-ribose) polymerase (PARP) enzymes play a key role in the regulation of cellular processes (e.g., DNA damage repair, genomic stability). It has been shown that PARP inhibitors (PARPIs) are selectively cytotoxic against cells having dysfunctions in genes involved in DNA repair mechanisms...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mini, Enrico, Landini, Ida, Lucarini, Laura, Lapucci, Andrea, Napoli, Cristina, Perrone, Gabriele, Tassi, Renato, Masini, Emanuela, Moroni, Flavio, Nobili, Stefania
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cognizant Communication Corporation 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7841208/ https://www.ncbi.nlm.nih.gov/pubmed/28429680 http://dx.doi.org/10.3727/096504017X14926854178616

Ejemplares similares

HYDAMTIQ, a selective PARP‐1 inhibitor, improves bleomycin‐induced lung fibrosis by dampening the TGF‐β/SMAD signalling pathway
por: Lucarini, Laura, et al.
Publicado: (2016)

Poly(ADP-ribose) polymerase inhibition with HYDAMTIQ reduces allergen-induced asthma-like reaction, bronchial hyper-reactivity and airway remodelling
por: Lucarini, Laura, et al.
Publicado: (2014)

Selection and characterization of a human ovarian cancer cell line resistant to auranofin
por: Landini, Ida, et al.
Publicado: (2017)

PNN and KCNQ1OT1 Can Predict the Efficacy of Adjuvant Fluoropyrimidine-Based Chemotherapy in Colorectal Cancer Patients
por: Lapucci, Andrea, et al.
Publicado: (2021)

Role of Non-Coding RNAs in Colorectal Cancer: Focus on Long Non-Coding RNAs
por: Lulli, Matteo, et al.
Publicado: (2022)

Vinorelbine in Non-Small Cell Lung Cancer: Real-World Data From a Single-Institution Experience
por: Nobili, Stefania, et al.
Publicado: (2020)

Effects of PARP-1 Deficiency and Histamine H(4) Receptor Inhibition in an Inflammatory Model of Lung Fibrosis in Mice
por: Durante, Mariaconcetta, et al.
Publicado: (2019)

Special Issue: “Gastrointestinal Cancers and Personalized Medicine”
por: Nobili, Stefania, et al.
Publicado: (2022)

“Pharmacogenetics of Cancer” - Cancer Drug Resistance special issue
por: Mini, Enrico, et al.
Publicado: (2020)

Editorial: Multidrug Resistance in Cancer: Pharmacological Strategies from Basic Research to Clinical Issues
por: Riganti, Chiara, et al.
Publicado: (2015)

In vitro assessment of antibody-conjugated gold nanorods for systemic injections
por: Centi, Sonia, et al.
Publicado: (2014)

Antiproliferative effects of two gold(I)-N-heterocyclic carbene complexes in A2780 human ovarian cancer cells: a comparative proteomic study
por: Magherini, Francesca, et al.
Publicado: (2018)

Exploratory Genome-Wide Association Analysis to Identify Pharmacogenetic Determinants of Response to R-CHOP in Diffuse Large B-Cell Lymphoma
por: Perrone, Gabriele, et al.
Publicado: (2023)

Cyclodextrin Inclusion Complexes of Auranofin and Its Iodido Analog: A Chemical and Biological Study
por: Cirri, Damiano, et al.
Publicado: (2021)

Novel Insight of Histamine and Its Receptor Ligands in Glaucoma and Retina Neuroprotection
por: Sgambellone, Silvia, et al.
Publicado: (2021)

New Insight in Histamine Functions
por: Sgambellone, Silvia, et al.
Publicado: (2022)

Defining the Ideal Patient with Hepatocellular Carcinoma for Second-Line Treatment
por: Roviello, Giandomenico, et al.
Publicado: (2020)

Focus on Biochemical and Clinical Predictors of Response to Immune Checkpoint Inhibitors in Metastatic Urothelial Carcinoma: Where Do We Stand?
por: Roviello, Giandomenico, et al.
Publicado: (2020)

Comparative inhibitory profile and distribution of bacterial PARPs, using Clostridioides difficile CD160 PARP as a model
por: García-Saura, Antonio Ginés, et al.
Publicado: (2018)

A case report of eyelid Merkel cell carcinoma occurring under treatment with nivolumab for a lung adenocarcinoma
por: Lavacchi, Daniele, et al.
Publicado: (2018)

Immune Checkpoint Inhibitors in Pre-Treated Gastric Cancer Patients: Results from a Literature-Based Meta-Analysis
por: Roviello, Giandomenico, et al.
Publicado: (2020)

Combination of Selective PARP3 and PARP16 Inhibitory Analogues of Latonduine A Corrects F508del-CFTR Trafficking
por: Centko, Ryan M., et al.
Publicado: (2020)

The Histamine H(4) Receptor Participates in the Anti-Neuropathic Effect of the Adenosine A(3) Receptor Agonist IB-MECA: Role of CD4(+) T Cells
por: Micheli, Laura, et al.
Publicado: (2021)

Fanconi Anemia Pathway in Colorectal Cancer: A Novel Opportunity for Diagnosis, Prognosis and Therapy
por: Parsa, Fatemeh Ghorbani, et al.
Publicado: (2022)

NCX 470 Exerts Retinal Cell Protection and Enhances Ophthalmic Artery Blood Flow After Ischemia/Reperfusion Injury of Optic Nerve Head and Retina
por: Sgambellone, Silvia, et al.
Publicado: (2023)

Efficacy Evaluation of Plant Products in the Treatment of Erectile Dysfunction Related to Diabetes
por: Nobili, Stefania, et al.
Publicado: (2021)

A Selective Histamine H(4) Receptor Antagonist, JNJ7777120, Is Protective in a Rat Model of Transient Cerebral Ischemia
por: Dettori, Ilaria, et al.
Publicado: (2018)

Defective neurogenesis and schizophrenia-like behavior in PARP-1-deficient mice
por: Hong, Seokheon, et al.
Publicado: (2019)

Loss of ATRX confers DNA repair defects and PARP inhibitor sensitivity
por: Garbarino, Jennifer, et al.
Publicado: (2021)

Encorafenib, Binimetinib, and Cetuximab in BRAF V600E-Mutated Colorectal Cancer
por: Roviello, Giandomenico, et al.
Publicado: (2020)

HLA-G 3’UTR Polymorphisms Impact the Prognosis of Stage II-III CRC Patients in Fluoropyrimidine-Based Treatment
por: Garziera, Marica, et al.
Publicado: (2015)

Hypersensitivity of BRCA2 deficient cells to rosemary extract explained by weak PARP inhibitory activity
por: Su, Cathy, et al.
Publicado: (2017)

Inhibitors of PARP-1 exert inhibitory effects on the biological characteristics of hepatocellular carcinoma cells in vitro
por: Mao, Xiaorong, et al.
Publicado: (2017)

A Class of 4-Sulfamoylphenyl-ω-aminoalkyl Ethers with Effective Carbonic Anhydrase Inhibitory Action and Antiglaucoma Effects
por: Bozdag, Murat, et al.
Publicado: (2014)

Immunomodulatory Roles of PARP-1 and PARP-2: Impact on PARP-Centered Cancer Therapies
por: Yélamos, José, et al.
Publicado: (2020)

Artificial Intelligence Predictive Models of Response to Cytotoxic Chemotherapy Alone or Combined to Targeted Therapy for Metastatic Colorectal Cancer Patients: A Systematic Review and Meta-Analysis
por: Russo, Valentina, et al.
Publicado: (2022)

PARP Power: A Structural Perspective on PARP1, PARP2, and PARP3 in DNA Damage Repair and Nucleosome Remodelling
por: van Beek, Lotte, et al.
Publicado: (2021)

Tumors defective in homologous recombination rely on oxidative metabolism: relevance to treatments with PARP inhibitors
por: Lahiguera, Álvaro, et al.
Publicado: (2020)

PARP Inhibitors in Endometrial Cancer: Current Status and Perspectives
por: Musacchio, Lucia, et al.
Publicado: (2020)

Capitalizing on ATRX loss in glioma via PARP inhibition: Comment on “Loss of ATRX confers DNA repair defects and PARP inhibitor sensitivity” by Garbarino et al.
por: Zalenski, Abigail A, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_3es6a3sjjtmu20qllomltnrfuh