Cargando…

Overexpression of Forkhead Box L1 (FOXL1) Inhibits the Proliferation and Invasion of Breast Cancer Cells

Forkhead box L1 (FOXL1) is a member of the Forkhead box (FOX) superfamily and was reported to be dysregulated in various types of cancers. However, its expression pattern and underlying cellular function in breast cancer remain largely unexplored. Thus, the aim of this study was to detect FOXL1 expr...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhong, Jiateng, Wang, Haijun, Yu, Jian, Zhang, Jinghang, Wang, Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cognizant Communication Corporation 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7841234/
https://www.ncbi.nlm.nih.gov/pubmed/27938507
http://dx.doi.org/10.3727/096504016X14803482769179
_version_ 1783643759668363264
author Zhong, Jiateng
Wang, Haijun
Yu, Jian
Zhang, Jinghang
Wang, Hui
author_facet Zhong, Jiateng
Wang, Haijun
Yu, Jian
Zhang, Jinghang
Wang, Hui
author_sort Zhong, Jiateng
collection PubMed
description Forkhead box L1 (FOXL1) is a member of the Forkhead box (FOX) superfamily and was reported to be dysregulated in various types of cancers. However, its expression pattern and underlying cellular function in breast cancer remain largely unexplored. Thus, the aim of this study was to detect FOXL1 expression in breast cancer and to analyze its role in the progression of breast cancer. Our results demonstrated that FOXL1 expression at both the mRNA and protein levels was downregulated in breast cancer tissues and cell lines. Ectopic FOXL1 suppressed breast cancer cell proliferation, migration, and invasion in vitro. Furthermore, overexpression of FOXL1 significantly attenuated tumor growth in breast xenograft models in vivo. Finally, overexpression of FOXL1 significantly downregulated the protein expression levels of β-catenin, c-Myc, and cyclin D1 in MDA-MB-231 cells. Taken together, the present study demonstrated that FOXL1 inhibited the proliferation, invasion, and migration of breast cancer in vitro and breast tumor growth in vivo through deactivating the Wnt/β-catenin signaling pathway. Thus, these findings suggest that FOXL1 may be a potential novel target for breast cancer therapy.
format Online
Article
Text
id pubmed-7841234
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Cognizant Communication Corporation
record_format MEDLINE/PubMed
spelling pubmed-78412342021-02-16 Overexpression of Forkhead Box L1 (FOXL1) Inhibits the Proliferation and Invasion of Breast Cancer Cells Zhong, Jiateng Wang, Haijun Yu, Jian Zhang, Jinghang Wang, Hui Oncol Res Article Forkhead box L1 (FOXL1) is a member of the Forkhead box (FOX) superfamily and was reported to be dysregulated in various types of cancers. However, its expression pattern and underlying cellular function in breast cancer remain largely unexplored. Thus, the aim of this study was to detect FOXL1 expression in breast cancer and to analyze its role in the progression of breast cancer. Our results demonstrated that FOXL1 expression at both the mRNA and protein levels was downregulated in breast cancer tissues and cell lines. Ectopic FOXL1 suppressed breast cancer cell proliferation, migration, and invasion in vitro. Furthermore, overexpression of FOXL1 significantly attenuated tumor growth in breast xenograft models in vivo. Finally, overexpression of FOXL1 significantly downregulated the protein expression levels of β-catenin, c-Myc, and cyclin D1 in MDA-MB-231 cells. Taken together, the present study demonstrated that FOXL1 inhibited the proliferation, invasion, and migration of breast cancer in vitro and breast tumor growth in vivo through deactivating the Wnt/β-catenin signaling pathway. Thus, these findings suggest that FOXL1 may be a potential novel target for breast cancer therapy. Cognizant Communication Corporation 2017-07-05 /pmc/articles/PMC7841234/ /pubmed/27938507 http://dx.doi.org/10.3727/096504016X14803482769179 Text en Copyright © 2017 Cognizant, LLC. http://creativecommons.org/licenses/by-nc-nd/4.0/ This article is licensed under a Creative Commons Attribution-NonCommercial NoDerivatives 4.0 International License.
spellingShingle Article
Zhong, Jiateng
Wang, Haijun
Yu, Jian
Zhang, Jinghang
Wang, Hui
Overexpression of Forkhead Box L1 (FOXL1) Inhibits the Proliferation and Invasion of Breast Cancer Cells
title Overexpression of Forkhead Box L1 (FOXL1) Inhibits the Proliferation and Invasion of Breast Cancer Cells
title_full Overexpression of Forkhead Box L1 (FOXL1) Inhibits the Proliferation and Invasion of Breast Cancer Cells
title_fullStr Overexpression of Forkhead Box L1 (FOXL1) Inhibits the Proliferation and Invasion of Breast Cancer Cells
title_full_unstemmed Overexpression of Forkhead Box L1 (FOXL1) Inhibits the Proliferation and Invasion of Breast Cancer Cells
title_short Overexpression of Forkhead Box L1 (FOXL1) Inhibits the Proliferation and Invasion of Breast Cancer Cells
title_sort overexpression of forkhead box l1 (foxl1) inhibits the proliferation and invasion of breast cancer cells
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7841234/
https://www.ncbi.nlm.nih.gov/pubmed/27938507
http://dx.doi.org/10.3727/096504016X14803482769179
work_keys_str_mv AT zhongjiateng overexpressionofforkheadboxl1foxl1inhibitstheproliferationandinvasionofbreastcancercells
AT wanghaijun overexpressionofforkheadboxl1foxl1inhibitstheproliferationandinvasionofbreastcancercells
AT yujian overexpressionofforkheadboxl1foxl1inhibitstheproliferationandinvasionofbreastcancercells
AT zhangjinghang overexpressionofforkheadboxl1foxl1inhibitstheproliferationandinvasionofbreastcancercells
AT wanghui overexpressionofforkheadboxl1foxl1inhibitstheproliferationandinvasionofbreastcancercells