Cargando…
Overexpression of Forkhead Box L1 (FOXL1) Inhibits the Proliferation and Invasion of Breast Cancer Cells
Forkhead box L1 (FOXL1) is a member of the Forkhead box (FOX) superfamily and was reported to be dysregulated in various types of cancers. However, its expression pattern and underlying cellular function in breast cancer remain largely unexplored. Thus, the aim of this study was to detect FOXL1 expr...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cognizant Communication Corporation
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7841234/ https://www.ncbi.nlm.nih.gov/pubmed/27938507 http://dx.doi.org/10.3727/096504016X14803482769179 |
_version_ | 1783643759668363264 |
---|---|
author | Zhong, Jiateng Wang, Haijun Yu, Jian Zhang, Jinghang Wang, Hui |
author_facet | Zhong, Jiateng Wang, Haijun Yu, Jian Zhang, Jinghang Wang, Hui |
author_sort | Zhong, Jiateng |
collection | PubMed |
description | Forkhead box L1 (FOXL1) is a member of the Forkhead box (FOX) superfamily and was reported to be dysregulated in various types of cancers. However, its expression pattern and underlying cellular function in breast cancer remain largely unexplored. Thus, the aim of this study was to detect FOXL1 expression in breast cancer and to analyze its role in the progression of breast cancer. Our results demonstrated that FOXL1 expression at both the mRNA and protein levels was downregulated in breast cancer tissues and cell lines. Ectopic FOXL1 suppressed breast cancer cell proliferation, migration, and invasion in vitro. Furthermore, overexpression of FOXL1 significantly attenuated tumor growth in breast xenograft models in vivo. Finally, overexpression of FOXL1 significantly downregulated the protein expression levels of β-catenin, c-Myc, and cyclin D1 in MDA-MB-231 cells. Taken together, the present study demonstrated that FOXL1 inhibited the proliferation, invasion, and migration of breast cancer in vitro and breast tumor growth in vivo through deactivating the Wnt/β-catenin signaling pathway. Thus, these findings suggest that FOXL1 may be a potential novel target for breast cancer therapy. |
format | Online Article Text |
id | pubmed-7841234 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Cognizant Communication Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-78412342021-02-16 Overexpression of Forkhead Box L1 (FOXL1) Inhibits the Proliferation and Invasion of Breast Cancer Cells Zhong, Jiateng Wang, Haijun Yu, Jian Zhang, Jinghang Wang, Hui Oncol Res Article Forkhead box L1 (FOXL1) is a member of the Forkhead box (FOX) superfamily and was reported to be dysregulated in various types of cancers. However, its expression pattern and underlying cellular function in breast cancer remain largely unexplored. Thus, the aim of this study was to detect FOXL1 expression in breast cancer and to analyze its role in the progression of breast cancer. Our results demonstrated that FOXL1 expression at both the mRNA and protein levels was downregulated in breast cancer tissues and cell lines. Ectopic FOXL1 suppressed breast cancer cell proliferation, migration, and invasion in vitro. Furthermore, overexpression of FOXL1 significantly attenuated tumor growth in breast xenograft models in vivo. Finally, overexpression of FOXL1 significantly downregulated the protein expression levels of β-catenin, c-Myc, and cyclin D1 in MDA-MB-231 cells. Taken together, the present study demonstrated that FOXL1 inhibited the proliferation, invasion, and migration of breast cancer in vitro and breast tumor growth in vivo through deactivating the Wnt/β-catenin signaling pathway. Thus, these findings suggest that FOXL1 may be a potential novel target for breast cancer therapy. Cognizant Communication Corporation 2017-07-05 /pmc/articles/PMC7841234/ /pubmed/27938507 http://dx.doi.org/10.3727/096504016X14803482769179 Text en Copyright © 2017 Cognizant, LLC. http://creativecommons.org/licenses/by-nc-nd/4.0/ This article is licensed under a Creative Commons Attribution-NonCommercial NoDerivatives 4.0 International License. |
spellingShingle | Article Zhong, Jiateng Wang, Haijun Yu, Jian Zhang, Jinghang Wang, Hui Overexpression of Forkhead Box L1 (FOXL1) Inhibits the Proliferation and Invasion of Breast Cancer Cells |
title | Overexpression of Forkhead Box L1 (FOXL1) Inhibits the Proliferation and Invasion of Breast Cancer Cells |
title_full | Overexpression of Forkhead Box L1 (FOXL1) Inhibits the Proliferation and Invasion of Breast Cancer Cells |
title_fullStr | Overexpression of Forkhead Box L1 (FOXL1) Inhibits the Proliferation and Invasion of Breast Cancer Cells |
title_full_unstemmed | Overexpression of Forkhead Box L1 (FOXL1) Inhibits the Proliferation and Invasion of Breast Cancer Cells |
title_short | Overexpression of Forkhead Box L1 (FOXL1) Inhibits the Proliferation and Invasion of Breast Cancer Cells |
title_sort | overexpression of forkhead box l1 (foxl1) inhibits the proliferation and invasion of breast cancer cells |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7841234/ https://www.ncbi.nlm.nih.gov/pubmed/27938507 http://dx.doi.org/10.3727/096504016X14803482769179 |
work_keys_str_mv | AT zhongjiateng overexpressionofforkheadboxl1foxl1inhibitstheproliferationandinvasionofbreastcancercells AT wanghaijun overexpressionofforkheadboxl1foxl1inhibitstheproliferationandinvasionofbreastcancercells AT yujian overexpressionofforkheadboxl1foxl1inhibitstheproliferationandinvasionofbreastcancercells AT zhangjinghang overexpressionofforkheadboxl1foxl1inhibitstheproliferationandinvasionofbreastcancercells AT wanghui overexpressionofforkheadboxl1foxl1inhibitstheproliferationandinvasionofbreastcancercells |