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Extensive cutaneous iatrogenic Kaposi’s sarcoma after bullous pemphigoid treatment with oral methylprednisolone: a rare Chinese case report

Bullous pemphigoid (BP) is an autoimmune disease that requires immunosuppressive therapy. Systemic corticosteroids are considered the standard treatment for moderate-to-severe BP. Kaposi’s sarcoma (KS) is a rare multifocal endothelial tumour that affects the skin, mucosa and viscera. As an angioprol...

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Autores principales: Chen, Sheng-An, Wang, Lan-Ting, Chen, Zi-Hua, Yang, Fan-Ping, Zhu, Qin-Yuan, Chen, Hu-Yan, Luo, Xiao-Qun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7841242/
https://www.ncbi.nlm.nih.gov/pubmed/33496629
http://dx.doi.org/10.1177/0300060520982829
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author Chen, Sheng-An
Wang, Lan-Ting
Chen, Zi-Hua
Yang, Fan-Ping
Zhu, Qin-Yuan
Chen, Hu-Yan
Luo, Xiao-Qun
author_facet Chen, Sheng-An
Wang, Lan-Ting
Chen, Zi-Hua
Yang, Fan-Ping
Zhu, Qin-Yuan
Chen, Hu-Yan
Luo, Xiao-Qun
author_sort Chen, Sheng-An
collection PubMed
description Bullous pemphigoid (BP) is an autoimmune disease that requires immunosuppressive therapy. Systemic corticosteroids are considered the standard treatment for moderate-to-severe BP. Kaposi’s sarcoma (KS) is a rare multifocal endothelial tumour that affects the skin, mucosa and viscera. As an angioproliferative disease of obscure aetiopathogenesis and histogenesis, KS is associated with human herpesvirus 8 (HHV-8). This current case report describes a rare occurrence of extensive cutaneous KS in a 60-year-old Chinese male patient after oral methylprednisolone treatment for BP with an emphasis on its pathological characterization. A total of more than 40 nodules were found on his trunk and lower limbs covering more than 20% of his body surface area. Immunohistochemical staining of biopsy samples from the lesion showed the patient was positive for HHV-8, CD31, CD34, XIIIa, ERG and Ki-67. The Epstein–Barr virus test showed the patient tested negative for immunoglobulin (Ig)A and IgM, but was positive for IgG. Immunosuppression associated with the treatment for BP may activate a latent HHV-8 infection and induce the development of KS.
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spelling pubmed-78412422021-02-05 Extensive cutaneous iatrogenic Kaposi’s sarcoma after bullous pemphigoid treatment with oral methylprednisolone: a rare Chinese case report Chen, Sheng-An Wang, Lan-Ting Chen, Zi-Hua Yang, Fan-Ping Zhu, Qin-Yuan Chen, Hu-Yan Luo, Xiao-Qun J Int Med Res Case Report Bullous pemphigoid (BP) is an autoimmune disease that requires immunosuppressive therapy. Systemic corticosteroids are considered the standard treatment for moderate-to-severe BP. Kaposi’s sarcoma (KS) is a rare multifocal endothelial tumour that affects the skin, mucosa and viscera. As an angioproliferative disease of obscure aetiopathogenesis and histogenesis, KS is associated with human herpesvirus 8 (HHV-8). This current case report describes a rare occurrence of extensive cutaneous KS in a 60-year-old Chinese male patient after oral methylprednisolone treatment for BP with an emphasis on its pathological characterization. A total of more than 40 nodules were found on his trunk and lower limbs covering more than 20% of his body surface area. Immunohistochemical staining of biopsy samples from the lesion showed the patient was positive for HHV-8, CD31, CD34, XIIIa, ERG and Ki-67. The Epstein–Barr virus test showed the patient tested negative for immunoglobulin (Ig)A and IgM, but was positive for IgG. Immunosuppression associated with the treatment for BP may activate a latent HHV-8 infection and induce the development of KS. SAGE Publications 2021-01-26 /pmc/articles/PMC7841242/ /pubmed/33496629 http://dx.doi.org/10.1177/0300060520982829 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by-nc/4.0/ Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Case Report
Chen, Sheng-An
Wang, Lan-Ting
Chen, Zi-Hua
Yang, Fan-Ping
Zhu, Qin-Yuan
Chen, Hu-Yan
Luo, Xiao-Qun
Extensive cutaneous iatrogenic Kaposi’s sarcoma after bullous pemphigoid treatment with oral methylprednisolone: a rare Chinese case report
title Extensive cutaneous iatrogenic Kaposi’s sarcoma after bullous pemphigoid treatment with oral methylprednisolone: a rare Chinese case report
title_full Extensive cutaneous iatrogenic Kaposi’s sarcoma after bullous pemphigoid treatment with oral methylprednisolone: a rare Chinese case report
title_fullStr Extensive cutaneous iatrogenic Kaposi’s sarcoma after bullous pemphigoid treatment with oral methylprednisolone: a rare Chinese case report
title_full_unstemmed Extensive cutaneous iatrogenic Kaposi’s sarcoma after bullous pemphigoid treatment with oral methylprednisolone: a rare Chinese case report
title_short Extensive cutaneous iatrogenic Kaposi’s sarcoma after bullous pemphigoid treatment with oral methylprednisolone: a rare Chinese case report
title_sort extensive cutaneous iatrogenic kaposi’s sarcoma after bullous pemphigoid treatment with oral methylprednisolone: a rare chinese case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7841242/
https://www.ncbi.nlm.nih.gov/pubmed/33496629
http://dx.doi.org/10.1177/0300060520982829
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