Cargando…

CCR2- and Flt3-Dependent Inflammatory Conventional Type 2 Dendritic Cells Are Necessary for the Induction of Adaptive Immunity by the Human Vaccine Adjuvant System AS01

The Adjuvant System AS01 contains monophosphoryl lipid A (MPL) and the saponin QS-21 in a liposomal formulation. AS01 is included in recently developed vaccines against malaria and varicella zoster virus. Like for many other adjuvants, induction of adaptive immunity by AS01 is highly dependent on th...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bosteels, Cedric, Fierens, Kaat, De Prijck, Sofie, Van Moorleghem, Justine, Vanheerswynghels, Manon, De Wolf, Caroline, Chalon, Aurélie, Collignon, Catherine, Hammad, Hamida, Didierlaurent, Arnaud M., Lambrecht, Bart N.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7841299/ https://www.ncbi.nlm.nih.gov/pubmed/33519816 http://dx.doi.org/10.3389/fimmu.2020.606805

Ejemplares similares

Role of NKp46(+) natural killer cells in house dust mite‐driven asthma
por: Haspeslagh, Eline, et al.
Publicado: (2018)

Myocardial Infarction Primes Autoreactive T Cells through Activation of Dendritic Cells
por: Van der Borght, Katrien, et al.
Publicado: (2017)

Inflammatory Type 2 cDCs Acquire Features of cDC1s and Macrophages to Orchestrate Immunity to Respiratory Virus Infection
por: Bosteels, Cedric, et al.
Publicado: (2020)

The ubiquitin-editing enzyme A20 controls NK cell homeostasis through regulation of mTOR activity and TNF
por: Vetters, Jessica, et al.
Publicado: (2019)

The transcriptome of lung tumor-infiltrating dendritic cells reveals a tumor-supporting phenotype and a microRNA signature with negative impact on clinical outcome
por: Pyfferoen, Lotte, et al.
Publicado: (2016)

Immunity induced by a broad class of inorganic crystalline materials is directly controlled by their chemistry
por: Williams, Gareth R., et al.
Publicado: (2014)

Alveolar macrophages develop from fetal monocytes that differentiate into long-lived cells in the first week of life via GM-CSF
por: Guilliams, Martin, et al.
Publicado: (2013)

Cellular and molecular synergy in AS01-adjuvanted vaccines results in an early IFNγ response promoting vaccine immunogenicity
por: Coccia, Margherita, et al.
Publicado: (2017)

Author Correction: Cellular and molecular synergy in AS01-adjuvanted vaccines results in an early IFNγ response promoting vaccine immunogenicity
por: Coccia, Margherita, et al.
Publicado: (2018)

Epitope mapping and kinetics of CD4 T cell immunity to pneumonia virus of mice in the C57BL/6 strain
por: Vandersarren, Lana, et al.
Publicado: (2017)

Central Role of CD169(+) Lymph Node Resident Macrophages in the Adjuvanticity of the QS-21 Component of AS01
por: Detienne, Sophie, et al.
Publicado: (2016)

Inflammatory dendritic cells—not basophils—are necessary and sufficient for induction of Th2 immunity to inhaled house dust mite allergen
por: Hammad, Hamida, et al.
Publicado: (2010)

A20-Deficient Mast Cells Exacerbate Inflammatory Responses In Vivo
por: Heger, Klaus, et al.
Publicado: (2014)

Application of Modeling Approaches to Explore Vaccine Adjuvant Mode-of-Action
por: Buckley, Paul R., et al.
Publicado: (2019)

Flt3L therapy increases the abundance of Treg-promoting CCR7(+) cDCs in preclinical cancer models
por: Clappaert, Emile J., et al.
Publicado: (2023)

TLR4 signalling in pulmonary stromal cells is critical for inflammation and immunity in the airways
por: Perros, Frederic, et al.
Publicado: (2011)

Cellular networks controlling Th2 polarization in allergy and immunity
por: Kool, Mirjam, et al.
Publicado: (2012)

The thermostability of the RTS,S/AS01 malaria vaccine can be increased by co-lyophilizing RTS,S and AS01
por: Fortpied, Juliette, et al.
Publicado: (2020)

CCR6 is not necessary for functional effects of human CCL18 in a mouse model
por: Luzina, Irina G, et al.
Publicado: (2012)

The hygiene hypothesis: immunological mechanisms of airway tolerance
por: Haspeslagh, Eline, et al.
Publicado: (2018)

Potential Roles of CCR5(+) CCR6(+) Dendritic Cells Induced by Nasal Ovalbumin plus Flt3 Ligand Expressing Adenovirus for Mucosal IgA Responses
por: Fukuyama, Yoshiko, et al.
Publicado: (2013)

TIM3(+) TRBV11-2 T cells and IFNγ signature in patrolling monocytes and CD16(+) NK cells delineate MIS-C
por: Hoste, Levi, et al.
Publicado: (2021)

β-Glucan exacerbates allergic airway responses to house dust mite allergen
por: Hadebe, Sabelo, et al.
Publicado: (2016)

Human Cytomegalovirus Encodes a Novel FLT3 Receptor Ligand Necessary for Hematopoietic Cell Differentiation and Viral Reactivation
por: Crawford, Lindsey B., et al.
Publicado: (2018)

Early IL-1 Signaling Promotes iBALT Induction after Influenza Virus Infection
por: Neyt, Katrijn, et al.
Publicado: (2016)

Tertiary lymphoid organs in infection and autoimmunity
por: Neyt, Katrijn, et al.
Publicado: (2012)

Chemokine Receptors CCR6 and CXCR3 Are Necessary for CD4(+) T Cell Mediated Ocular Surface Disease in Experimental Dry Eye Disease
por: Coursey, Terry G., et al.
Publicado: (2013)

Innate Immune Responses to Chimpanzee Adenovirus Vector 155 Vaccination in Mice and Monkeys
por: Collignon, Catherine, et al.
Publicado: (2020)

Therapeutic Vulnerabilities in FLT3-Mutant AML Unmasked by Palbociclib
por: Uras, Iris Z., et al.
Publicado: (2018)

Further Activation of FLT3 Mutants by FLT3 Ligand
por: Zheng, Rui, et al.
Publicado: (2011)

OR16-01 The Expression of the Homeodomain Transcription Factor SIX3 within Kisspeptin Neurons Is Necessary for Reproduction in Mice
por: Lavalle, Shanna N, et al.
Publicado: (2020)

The implication of FLT3 amplification for FLT targeted therapeutics in solid tumors
por: Lim, Sung Hee, et al.
Publicado: (2016)

Activation of the D prostanoid 1 receptor suppresses asthma by modulation of lung dendritic cell function and induction of regulatory T cells
por: Hammad, Hamida, et al.
Publicado: (2007)

CC Chemokines in a Tumor: A Review of Pro-Cancer and Anti-Cancer Properties of Receptors CCR5, CCR6, CCR7, CCR8, CCR9, and CCR10 Ligands
por: Korbecki, Jan, et al.
Publicado: (2020)

Estimating the Threshold Surface Density of Gp120-CCR5 Complexes Necessary for HIV-1 Envelope-Mediated Cell-Cell Fusion
por: Mulampaka, Shiva Naresh, et al.
Publicado: (2011)

Combination of ATO with FLT3 TKIs eliminates FLT3/ITD+ leukemia cells through reduced expression of FLT3
por: Nagai, Kozo, et al.
Publicado: (2018)

OTS167 blocks FLT3 translation and synergizes with FLT3 inhibitors in FLT3 mutant acute myeloid leukemia
por: Eisfelder, Bartholomew J., et al.
Publicado: (2021)

Bone marrow-derived monocytes give rise to self-renewing and fully differentiated Kupffer cells
por: Scott, Charlotte L., et al.
Publicado: (2016)

Interleukin-1α controls allergic sensitization to inhaled house dust mite via the epithelial release of GM-CSF and IL-33
por: Willart, Monique A.M., et al.
Publicado: (2012)

Overcoming Resistance to FLT3 Inhibitors in the Treatment of FLT3-Mutated AML
por: Lam, Stephen S.Y., et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_lhoml0hb5nna7h31s7fupvbfl0