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Preliminary Characterization of Dog Derived Pathogenic Strains of Leptospira interrogans Serovar Australis in Nanchang of Jiangxi Province, China

Leptospirosis is a global zoonotic disease caused by pathogenic Leptospira, and those infected animals will show a variety of clinical symptoms and even death. The discovery of endemic strains is crucial to produce effective vaccines. In this study, we report that a strain of Leptospira, isolated fr...

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Autores principales: Song, Ning, Zhang, Wenlong, Ding, Yue, Wu, Dianjun, Dai, Zonghao, Xu, Li, Cao, Yongguo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7841341/
https://www.ncbi.nlm.nih.gov/pubmed/33521082
http://dx.doi.org/10.3389/fvets.2020.607115
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author Song, Ning
Zhang, Wenlong
Ding, Yue
Wu, Dianjun
Dai, Zonghao
Xu, Li
Cao, Yongguo
author_facet Song, Ning
Zhang, Wenlong
Ding, Yue
Wu, Dianjun
Dai, Zonghao
Xu, Li
Cao, Yongguo
author_sort Song, Ning
collection PubMed
description Leptospirosis is a global zoonotic disease caused by pathogenic Leptospira, and those infected animals will show a variety of clinical symptoms and even death. The discovery of endemic strains is crucial to produce effective vaccines. In this study, we report that a strain of Leptospira, isolated from a dog, is pathogenic. Using MLST analysis, the serovar of isolated Leptospira was identified and found it belongs to Leptospira interrogation Serovar Australis. Then, the virulence of this strain was researched by using hamsters. After infection, all the hamsters died within 4–5 days. Typical pathological changes were found in the liver, kidney, and lung of hamsters. These results all indicated that the isolated Leptospira was pathogenic. Thus, this study facilitates to identifying local Leptospira strains and develop a more targeted canine Leptospira vaccine.
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spelling pubmed-78413412021-01-29 Preliminary Characterization of Dog Derived Pathogenic Strains of Leptospira interrogans Serovar Australis in Nanchang of Jiangxi Province, China Song, Ning Zhang, Wenlong Ding, Yue Wu, Dianjun Dai, Zonghao Xu, Li Cao, Yongguo Front Vet Sci Veterinary Science Leptospirosis is a global zoonotic disease caused by pathogenic Leptospira, and those infected animals will show a variety of clinical symptoms and even death. The discovery of endemic strains is crucial to produce effective vaccines. In this study, we report that a strain of Leptospira, isolated from a dog, is pathogenic. Using MLST analysis, the serovar of isolated Leptospira was identified and found it belongs to Leptospira interrogation Serovar Australis. Then, the virulence of this strain was researched by using hamsters. After infection, all the hamsters died within 4–5 days. Typical pathological changes were found in the liver, kidney, and lung of hamsters. These results all indicated that the isolated Leptospira was pathogenic. Thus, this study facilitates to identifying local Leptospira strains and develop a more targeted canine Leptospira vaccine. Frontiers Media S.A. 2021-01-14 /pmc/articles/PMC7841341/ /pubmed/33521082 http://dx.doi.org/10.3389/fvets.2020.607115 Text en Copyright © 2021 Song, Zhang, Ding, Wu, Dai, Xu and Cao. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Veterinary Science
Song, Ning
Zhang, Wenlong
Ding, Yue
Wu, Dianjun
Dai, Zonghao
Xu, Li
Cao, Yongguo
Preliminary Characterization of Dog Derived Pathogenic Strains of Leptospira interrogans Serovar Australis in Nanchang of Jiangxi Province, China
title Preliminary Characterization of Dog Derived Pathogenic Strains of Leptospira interrogans Serovar Australis in Nanchang of Jiangxi Province, China
title_full Preliminary Characterization of Dog Derived Pathogenic Strains of Leptospira interrogans Serovar Australis in Nanchang of Jiangxi Province, China
title_fullStr Preliminary Characterization of Dog Derived Pathogenic Strains of Leptospira interrogans Serovar Australis in Nanchang of Jiangxi Province, China
title_full_unstemmed Preliminary Characterization of Dog Derived Pathogenic Strains of Leptospira interrogans Serovar Australis in Nanchang of Jiangxi Province, China
title_short Preliminary Characterization of Dog Derived Pathogenic Strains of Leptospira interrogans Serovar Australis in Nanchang of Jiangxi Province, China
title_sort preliminary characterization of dog derived pathogenic strains of leptospira interrogans serovar australis in nanchang of jiangxi province, china
topic Veterinary Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7841341/
https://www.ncbi.nlm.nih.gov/pubmed/33521082
http://dx.doi.org/10.3389/fvets.2020.607115
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