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Melatonin Lowers HIF-1α Content in Human Proximal Tubular Cells (HK-2) Due to Preventing Its Deacetylation by Sirtuin 1

Although melatonin is widely known for its nephroprotective properties, there are no reports clearly pointing at its impact on the activity of hypoxia-inducible factor-1 (HIF-1), the main mediator of metabolic responses to hypoxia, in kidneys. The aim of the present study was to elucidate how melato...

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Detalles Bibliográficos
Autores principales:	Owczarek, Aleksandra, Gieczewska, Katarzyna B., Polanska, Marta, Paterczyk, Bohdan, Gruza, Andrzej, Winiarska, Katarzyna
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Physiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7841413/ https://www.ncbi.nlm.nih.gov/pubmed/33519498 http://dx.doi.org/10.3389/fphys.2020.572911

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