Deficient Endoplasmic Reticulum Acetyl-CoA Import in Pancreatic Acinar Cells Leads to Chronic Pancreatitis

BACKGROUND & AIMS: Maintaining endoplasmic reticulum (ER) proteostasis is essential for pancreatic acinar cell function. Under conditions of severe ER stress, activation of pathogenic unfolded protein response pathways plays a central role in the development and progression of pancreatitis. Less...

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Detalles Bibliográficos
Autores principales: Cooley, Michelle M., Thomas, Diana D.H., Deans, Kali, Peng, Yajing, Lugea, Aurelia, Pandol, Stephen J., Puglielli, Luigi, Groblewski, Guy E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7841443/
https://www.ncbi.nlm.nih.gov/pubmed/33080365
http://dx.doi.org/10.1016/j.jcmgh.2020.10.008

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