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Peripheral Inflammatory Cytokines and Lymphocyte Subset Features of Deceased COVID-19 Patients

OBJECTIVE: To compare the difference of inflammatory cytokines and lymphocyte subsets between deceased patients and survivors with COVID-19. METHODS: This retrospective study included 254 confirmed patients from 10 January to 11 March, 2020, at Tongji Hospital of Wuhan, China. Laboratory and immunol...

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Autores principales: Jiang, Nan, Li, Zhijun, Yang, Bo, Jin, Mengdi, Sun, Yaoyao, He, Yang, Liu, Yang, Wang, Yueying, Si, Daoyuan, Ma, Piyong, Zhang, Jinnan, Liu, Tianji, Yu, Qiong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7841449/
https://www.ncbi.nlm.nih.gov/pubmed/33542929
http://dx.doi.org/10.1155/2021/9101082
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author Jiang, Nan
Li, Zhijun
Yang, Bo
Jin, Mengdi
Sun, Yaoyao
He, Yang
Liu, Yang
Wang, Yueying
Si, Daoyuan
Ma, Piyong
Zhang, Jinnan
Liu, Tianji
Yu, Qiong
author_facet Jiang, Nan
Li, Zhijun
Yang, Bo
Jin, Mengdi
Sun, Yaoyao
He, Yang
Liu, Yang
Wang, Yueying
Si, Daoyuan
Ma, Piyong
Zhang, Jinnan
Liu, Tianji
Yu, Qiong
author_sort Jiang, Nan
collection PubMed
description OBJECTIVE: To compare the difference of inflammatory cytokines and lymphocyte subsets between deceased patients and survivors with COVID-19. METHODS: This retrospective study included 254 confirmed patients from 10 January to 11 March, 2020, at Tongji Hospital of Wuhan, China. Laboratory and immunologic features were collected and analyzed, and the main outcomes focused on inflammatory cytokines and lymphocyte subsets. RESULTS: A trend of markedly higher levels of inflammatory cytokines as well as lower lymphocyte subset levels in deceased patients was observed compared with survivors. ROC curve analyses indicated that inflammatory cytokines and the decrease levels of T cell, Th (helper T cells) cell, Ts (suppressor T cells) cell, B cell, and NK cell along with Th/Ts ratio increase could be used to predict the death of COVID-19. Multivariate analyses showed that higher levels of IL-6, IL-8, and IL-10 remained significantly correlated with shorter survival time and that the amount of Ts cells was negatively associated with the possibility of death in COVID-19 patients. In conclusion, SARS-CoV-2 would cause lymphopenia and result in decreased lymphocyte subset cells, particularly in Ts cell counts, which further induces hyperinflammatory response and cytokine storm. IL-6, IL-8, IL-10, and Ts cell might be independent predictors for the poor outcome of COVID-19.
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spelling pubmed-78414492021-02-03 Peripheral Inflammatory Cytokines and Lymphocyte Subset Features of Deceased COVID-19 Patients Jiang, Nan Li, Zhijun Yang, Bo Jin, Mengdi Sun, Yaoyao He, Yang Liu, Yang Wang, Yueying Si, Daoyuan Ma, Piyong Zhang, Jinnan Liu, Tianji Yu, Qiong Biomed Res Int Research Article OBJECTIVE: To compare the difference of inflammatory cytokines and lymphocyte subsets between deceased patients and survivors with COVID-19. METHODS: This retrospective study included 254 confirmed patients from 10 January to 11 March, 2020, at Tongji Hospital of Wuhan, China. Laboratory and immunologic features were collected and analyzed, and the main outcomes focused on inflammatory cytokines and lymphocyte subsets. RESULTS: A trend of markedly higher levels of inflammatory cytokines as well as lower lymphocyte subset levels in deceased patients was observed compared with survivors. ROC curve analyses indicated that inflammatory cytokines and the decrease levels of T cell, Th (helper T cells) cell, Ts (suppressor T cells) cell, B cell, and NK cell along with Th/Ts ratio increase could be used to predict the death of COVID-19. Multivariate analyses showed that higher levels of IL-6, IL-8, and IL-10 remained significantly correlated with shorter survival time and that the amount of Ts cells was negatively associated with the possibility of death in COVID-19 patients. In conclusion, SARS-CoV-2 would cause lymphopenia and result in decreased lymphocyte subset cells, particularly in Ts cell counts, which further induces hyperinflammatory response and cytokine storm. IL-6, IL-8, IL-10, and Ts cell might be independent predictors for the poor outcome of COVID-19. Hindawi 2021-01-22 /pmc/articles/PMC7841449/ /pubmed/33542929 http://dx.doi.org/10.1155/2021/9101082 Text en Copyright © 2021 Nan Jiang et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Jiang, Nan
Li, Zhijun
Yang, Bo
Jin, Mengdi
Sun, Yaoyao
He, Yang
Liu, Yang
Wang, Yueying
Si, Daoyuan
Ma, Piyong
Zhang, Jinnan
Liu, Tianji
Yu, Qiong
Peripheral Inflammatory Cytokines and Lymphocyte Subset Features of Deceased COVID-19 Patients
title Peripheral Inflammatory Cytokines and Lymphocyte Subset Features of Deceased COVID-19 Patients
title_full Peripheral Inflammatory Cytokines and Lymphocyte Subset Features of Deceased COVID-19 Patients
title_fullStr Peripheral Inflammatory Cytokines and Lymphocyte Subset Features of Deceased COVID-19 Patients
title_full_unstemmed Peripheral Inflammatory Cytokines and Lymphocyte Subset Features of Deceased COVID-19 Patients
title_short Peripheral Inflammatory Cytokines and Lymphocyte Subset Features of Deceased COVID-19 Patients
title_sort peripheral inflammatory cytokines and lymphocyte subset features of deceased covid-19 patients
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7841449/
https://www.ncbi.nlm.nih.gov/pubmed/33542929
http://dx.doi.org/10.1155/2021/9101082
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