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Understanding racial differences of COPD patients with an ecological model: two large cohort studies in the US and Korea
BACKGROUND: There are limited data about the racial difference in the characteristics of chronic obstructive pulmonary disease (COPD) patients who are treated at clinics. We aimed to compare sociodemographic and clinical characteristics between US and Korean COPD patients using large-scale nationwid...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7841674/ https://www.ncbi.nlm.nih.gov/pubmed/33613934 http://dx.doi.org/10.1177/2040622320982455 |
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author | Park, Hye Yun Lee, Hyun Kang, Danbee Choi, Hye Sook Ryu, Yeong Ha Jung, Ki-Suck Sin, Don D. Cho, Juhee Yoo, Kwang Ha |
author_facet | Park, Hye Yun Lee, Hyun Kang, Danbee Choi, Hye Sook Ryu, Yeong Ha Jung, Ki-Suck Sin, Don D. Cho, Juhee Yoo, Kwang Ha |
author_sort | Park, Hye Yun |
collection | PubMed |
description | BACKGROUND: There are limited data about the racial difference in the characteristics of chronic obstructive pulmonary disease (COPD) patients who are treated at clinics. We aimed to compare sociodemographic and clinical characteristics between US and Korean COPD patients using large-scale nationwide COPD cohorts. METHODS: We used the baseline demographic and clinical data of COPD patients aged 45 years or older with at least a 10 pack-per year smoking history from the Korean COPD Subtype Study (KOCOSS, n = 1686) cohort (2012–2018) and phase I (2008–2011) of the US Genetic Epidemiology of COPD (COPDGene) study (n = 4477, 3461 were non-Hispanic whites [NHW], and 1016 were African Americans [AA]). RESULTS: Compared to NHW, AA had a significantly lower adjusted prevalence ratio (aPR) of cough >3 months (aPR: 0.67; 95% CI [confidence interval]: 0.60–0.75) and phlegm >3 months (aPR: 0.78, 95% CI: 0.70–0.86), but higher aPR of dyspnea (modified Medical Round Council scale ⩾2) (aPR: 1.22; 95% CI: 1.15–1.29), short six-minute walk distance (<350 m) (aPR: 1.98; 95% CI: 1.81–2.14), and poor quality of life (aPR: 1.10; 95% CI: 1.05–1.15). Compared to NHW, Koreans had a significantly lower aPR of cough >3 months (aPR: 0.53; 95% CI: 0.47–0.59), phlegm >3 months (aPR: 0.75; 95% CI: 0.67–0.82), dyspnea (aPR: 0.72; 95% CI: 0.66–0.79), and moderate-to-severe acute exacerbation in the previous year (aPR: 0.73; 95% CI: 0.65–0.82). NHW had the highest burden related to chronic bronchitis symptoms and cardiovascular diseases related to comorbidities. CONCLUSION: There are substantial differences in sociodemographic characteristics, clinical presentation, and comorbidities between COPD patients from the KOCOSS and COPDGene, which might be caused by interactions between various intrapersonal, interpersonal, and environmental factors of the ecological model. Thus, a broader and more comprehensive approach would be necessary to understand the racial differences of COPD patients. |
format | Online Article Text |
id | pubmed-7841674 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-78416742021-02-19 Understanding racial differences of COPD patients with an ecological model: two large cohort studies in the US and Korea Park, Hye Yun Lee, Hyun Kang, Danbee Choi, Hye Sook Ryu, Yeong Ha Jung, Ki-Suck Sin, Don D. Cho, Juhee Yoo, Kwang Ha Ther Adv Chronic Dis Original Research BACKGROUND: There are limited data about the racial difference in the characteristics of chronic obstructive pulmonary disease (COPD) patients who are treated at clinics. We aimed to compare sociodemographic and clinical characteristics between US and Korean COPD patients using large-scale nationwide COPD cohorts. METHODS: We used the baseline demographic and clinical data of COPD patients aged 45 years or older with at least a 10 pack-per year smoking history from the Korean COPD Subtype Study (KOCOSS, n = 1686) cohort (2012–2018) and phase I (2008–2011) of the US Genetic Epidemiology of COPD (COPDGene) study (n = 4477, 3461 were non-Hispanic whites [NHW], and 1016 were African Americans [AA]). RESULTS: Compared to NHW, AA had a significantly lower adjusted prevalence ratio (aPR) of cough >3 months (aPR: 0.67; 95% CI [confidence interval]: 0.60–0.75) and phlegm >3 months (aPR: 0.78, 95% CI: 0.70–0.86), but higher aPR of dyspnea (modified Medical Round Council scale ⩾2) (aPR: 1.22; 95% CI: 1.15–1.29), short six-minute walk distance (<350 m) (aPR: 1.98; 95% CI: 1.81–2.14), and poor quality of life (aPR: 1.10; 95% CI: 1.05–1.15). Compared to NHW, Koreans had a significantly lower aPR of cough >3 months (aPR: 0.53; 95% CI: 0.47–0.59), phlegm >3 months (aPR: 0.75; 95% CI: 0.67–0.82), dyspnea (aPR: 0.72; 95% CI: 0.66–0.79), and moderate-to-severe acute exacerbation in the previous year (aPR: 0.73; 95% CI: 0.65–0.82). NHW had the highest burden related to chronic bronchitis symptoms and cardiovascular diseases related to comorbidities. CONCLUSION: There are substantial differences in sociodemographic characteristics, clinical presentation, and comorbidities between COPD patients from the KOCOSS and COPDGene, which might be caused by interactions between various intrapersonal, interpersonal, and environmental factors of the ecological model. Thus, a broader and more comprehensive approach would be necessary to understand the racial differences of COPD patients. SAGE Publications 2021-01-22 /pmc/articles/PMC7841674/ /pubmed/33613934 http://dx.doi.org/10.1177/2040622320982455 Text en © The Author(s), 2021 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Original Research Park, Hye Yun Lee, Hyun Kang, Danbee Choi, Hye Sook Ryu, Yeong Ha Jung, Ki-Suck Sin, Don D. Cho, Juhee Yoo, Kwang Ha Understanding racial differences of COPD patients with an ecological model: two large cohort studies in the US and Korea |
title | Understanding racial differences of COPD patients with an ecological model: two large cohort studies in the US and Korea |
title_full | Understanding racial differences of COPD patients with an ecological model: two large cohort studies in the US and Korea |
title_fullStr | Understanding racial differences of COPD patients with an ecological model: two large cohort studies in the US and Korea |
title_full_unstemmed | Understanding racial differences of COPD patients with an ecological model: two large cohort studies in the US and Korea |
title_short | Understanding racial differences of COPD patients with an ecological model: two large cohort studies in the US and Korea |
title_sort | understanding racial differences of copd patients with an ecological model: two large cohort studies in the us and korea |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7841674/ https://www.ncbi.nlm.nih.gov/pubmed/33613934 http://dx.doi.org/10.1177/2040622320982455 |
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