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Notch signaling drives synovial fibroblast identity and arthritis pathology
The synovium is a mesenchymal tissue composed mainly of fibroblasts with a lining and sublining that surrounds the joints. In rheumatoid arthritis (RA), the synovial tissue undergoes marked hyperplasia, becomes inflamed and invasive and destroys the joint(1,2). Recently, we and others found that a s...
Autores principales: | , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7841716/ https://www.ncbi.nlm.nih.gov/pubmed/32499639 http://dx.doi.org/10.1038/s41586-020-2222-z |