Methotrexate enhances antigen presentation and maturation of tumour antigen-loaded dendritic cells through NLRP3 inflammasome activation: a strategy for dendritic cell-based cancer vaccine

BACKGROUND: Dendritic cells (DCs) are antigen-presenting cells that play a pivotal role in adaptive cell-mediated immunity by priming and activating T cells against specific tumour and pathogenic antigens. Methotrexate (MTX), a folate derivative, functions as an immunoregulatory agent. However, the...

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Detalles Bibliográficos
Autores principales: Shi, Gao-Na, Hu, Min, Chen, Chengjuan, Fu, Junmin, Shao, Shuai, Zhou, Yu, Wu, Lei, Zhang, Tiantai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2021
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7841859/
https://www.ncbi.nlm.nih.gov/pubmed/33613696
http://dx.doi.org/10.1177/1758835920987056

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7841859/
https://www.ncbi.nlm.nih.gov/pubmed/33613696
http://dx.doi.org/10.1177/1758835920987056

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