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Methotrexate enhances antigen presentation and maturation of tumour antigen-loaded dendritic cells through NLRP3 inflammasome activation: a strategy for dendritic cell-based cancer vaccine

BACKGROUND: Dendritic cells (DCs) are antigen-presenting cells that play a pivotal role in adaptive cell-mediated immunity by priming and activating T cells against specific tumour and pathogenic antigens. Methotrexate (MTX), a folate derivative, functions as an immunoregulatory agent. However, the...

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Detalles Bibliográficos
Autores principales:	Shi, Gao-Na, Hu, Min, Chen, Chengjuan, Fu, Junmin, Shao, Shuai, Zhou, Yu, Wu, Lei, Zhang, Tiantai
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	SAGE Publications 2021
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7841859/ https://www.ncbi.nlm.nih.gov/pubmed/33613696 http://dx.doi.org/10.1177/1758835920987056

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