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Severe Candida glabrata pancolitis and fatal Aspergillus fumigatus pulmonary infection in the setting of bone marrow aplasia after CD19-directed CAR T-cell therapy – a case report

BACKGROUND: Prolonged myelosuppression following CD19-directed CAR T-cell transfusion represents an important, yet underreported, adverse event. The resulting neutropenia and multifactorial immunosuppression can facilitate severe infectious complications. CASE PRESENTATION: We describe the clinical...

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Detalles Bibliográficos
Autores principales: Rejeski, Kai, Kunz, Wolfgang G., Rudelius, Martina, Bücklein, Veit, Blumenberg, Viktoria, Schmidt, Christian, Karschnia, Philipp, Schöberl, Florian, Dimitriadis, Konstantin, von Baumgarten, Louisa, Stemmler, Joachim, Weigert, Oliver, Dreyling, Martin, von Bergwelt-Baildon, Michael, Subklewe, Marion
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7841988/
https://www.ncbi.nlm.nih.gov/pubmed/33509115
http://dx.doi.org/10.1186/s12879-020-05755-4