ADAR1 is a new target of METTL3 and plays a pro-oncogenic role in glioblastoma by an editing-independent mechanism

BACKGROUND: N(6)-methyladenosine (m6A) and adenosine-to-inosine (A-to-I) RNA editing are two of the most abundant RNA modification events affecting adenosines in mammals. Both these RNA modifications determine mRNA fate and play a pivotal role in tumor development and progression. RESULTS: Here, we...

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Detalles Bibliográficos
Autores principales: Tassinari, Valentina, Cesarini, Valeriana, Tomaselli, Sara, Ianniello, Zaira, Silvestris, Domenico Alessandro, Ginistrelli, Lavinia Ceci, Martini, Maurizio, De Angelis, Biagio, De Luca, Gabriele, Vitiani, Lucia Ricci, Fatica, Alessandro, Locatelli, Franco, Gallo, Angela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7842030/
https://www.ncbi.nlm.nih.gov/pubmed/33509238
http://dx.doi.org/10.1186/s13059-021-02271-9

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