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Changes in the regional homogeneity of resting-state magnetic resonance imaging in perimenopausal women

BACKGROUND: There is a noticeable lack of systematic researches on evaluating the correlation between serum estrogen levels and changes in brain functional areas of perimenopausal women.The aim of this study is to investigate the regional spontaneous brain activity changes in perimenopausal women. M...

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Autores principales: Liu, Min, Yang, Hui, Qin, Jian, Yao, Qianqian, Yang, Guihua, Li, Jiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7842067/
https://www.ncbi.nlm.nih.gov/pubmed/33509177
http://dx.doi.org/10.1186/s12905-020-01171-7
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author Liu, Min
Yang, Hui
Qin, Jian
Yao, Qianqian
Yang, Guihua
Li, Jiang
author_facet Liu, Min
Yang, Hui
Qin, Jian
Yao, Qianqian
Yang, Guihua
Li, Jiang
author_sort Liu, Min
collection PubMed
description BACKGROUND: There is a noticeable lack of systematic researches on evaluating the correlation between serum estrogen levels and changes in brain functional areas of perimenopausal women.The aim of this study is to investigate the regional spontaneous brain activity changes in perimenopausal women. METHODS: Based on the resting-state functional magnetic resonance imaging datasets acquired from 25 perimenopausal women and 20 healthy women of reproductive age, a two-sample t-test was performed on individual normalized regional homogeneity (ReHo) maps. Relationships between abnormal ReHo values and the self-rating anxiety scale (SAS), the self-rating depression scale (SDS) were investigated with Pearson correlation analysis. We also investigated the correlation between abnormal ReHo values and serum estrogen level. RESULTS: In the perimenopausal group, we found increased ReHo in the right posterior cerebellum (region 2), left middle frontal gyrus and left middle cingulate gyrus ([Formula: see text] ). Additionally, the ReHo values in left middle frontal gyrus and leftt middle cingulate gyrus showed positively significant correlation with the SAS, SDS scores. On the contrary, there was no significant correlation between the ReHo value in right posterior cerebellum and SDS, SAS scores. In the perimenopausal group, the ReHo values in the left middle frontal gyrus and left middle cingulate gyrus were negatively correlated with the serum estrogen level ([Formula: see text] ). CONCLUSION: The results of this preliminary study have suggested that abnormal spontaneous activities of multiple brain regions during resting state was already altered in perimenopausal women. Alterative activities might be related to emotional regulation deficits and cognitive impairment, and might potentially represent the neural mechanism underlying perimenopausal period.
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spelling pubmed-78420672021-01-28 Changes in the regional homogeneity of resting-state magnetic resonance imaging in perimenopausal women Liu, Min Yang, Hui Qin, Jian Yao, Qianqian Yang, Guihua Li, Jiang BMC Womens Health Research Article BACKGROUND: There is a noticeable lack of systematic researches on evaluating the correlation between serum estrogen levels and changes in brain functional areas of perimenopausal women.The aim of this study is to investigate the regional spontaneous brain activity changes in perimenopausal women. METHODS: Based on the resting-state functional magnetic resonance imaging datasets acquired from 25 perimenopausal women and 20 healthy women of reproductive age, a two-sample t-test was performed on individual normalized regional homogeneity (ReHo) maps. Relationships between abnormal ReHo values and the self-rating anxiety scale (SAS), the self-rating depression scale (SDS) were investigated with Pearson correlation analysis. We also investigated the correlation between abnormal ReHo values and serum estrogen level. RESULTS: In the perimenopausal group, we found increased ReHo in the right posterior cerebellum (region 2), left middle frontal gyrus and left middle cingulate gyrus ([Formula: see text] ). Additionally, the ReHo values in left middle frontal gyrus and leftt middle cingulate gyrus showed positively significant correlation with the SAS, SDS scores. On the contrary, there was no significant correlation between the ReHo value in right posterior cerebellum and SDS, SAS scores. In the perimenopausal group, the ReHo values in the left middle frontal gyrus and left middle cingulate gyrus were negatively correlated with the serum estrogen level ([Formula: see text] ). CONCLUSION: The results of this preliminary study have suggested that abnormal spontaneous activities of multiple brain regions during resting state was already altered in perimenopausal women. Alterative activities might be related to emotional regulation deficits and cognitive impairment, and might potentially represent the neural mechanism underlying perimenopausal period. BioMed Central 2021-01-28 /pmc/articles/PMC7842067/ /pubmed/33509177 http://dx.doi.org/10.1186/s12905-020-01171-7 Text en © The Author(s) 2021 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Article
Liu, Min
Yang, Hui
Qin, Jian
Yao, Qianqian
Yang, Guihua
Li, Jiang
Changes in the regional homogeneity of resting-state magnetic resonance imaging in perimenopausal women
title Changes in the regional homogeneity of resting-state magnetic resonance imaging in perimenopausal women
title_full Changes in the regional homogeneity of resting-state magnetic resonance imaging in perimenopausal women
title_fullStr Changes in the regional homogeneity of resting-state magnetic resonance imaging in perimenopausal women
title_full_unstemmed Changes in the regional homogeneity of resting-state magnetic resonance imaging in perimenopausal women
title_short Changes in the regional homogeneity of resting-state magnetic resonance imaging in perimenopausal women
title_sort changes in the regional homogeneity of resting-state magnetic resonance imaging in perimenopausal women
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7842067/
https://www.ncbi.nlm.nih.gov/pubmed/33509177
http://dx.doi.org/10.1186/s12905-020-01171-7
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