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Pharmacokinetics and pharmacodynamics of hydroxychloroquine in hospitalized patients with COVID-19

BACKGROUND: Hydroxychloroquine (HCQ) dosage required to reach circulating levels that inhibit SARS-Cov-2 are extrapolated from pharmacokinetic data in non-COVID-19 patients. METHODS: We performed a population-pharmacokinetic analysis from 104 consecutive COVID-19 hospitalized patients (31 in intensi...

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Detalles Bibliográficos
Autores principales:	Zahr, Noël, Urien, Saik, Llopis, Benoit, Pourcher, Valérie, Paccoud, Olivier, Bleibtreu, Alexandre, Mayaux, Julien, Gandjbakhch, Estelle, Hekimian, Guillaume, Combes, Alain, Benveniste, Olivier, Saadoun, David, Allenbach, Yves, Pinna, Bruno, Cacoub, Patrice, Funck-Brentano, Christian, Salem, Joe-Elie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Société française de pharmacologie et de thérapeutique. Published by Elsevier Masson SAS. 2021
Materias:	Clinical Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7842207/ https://www.ncbi.nlm.nih.gov/pubmed/33558079 http://dx.doi.org/10.1016/j.therap.2021.01.056

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