Cargando…

Proteasomal degradation of human SERINC4: A potent host anti-HIV-1 factor that is antagonized by nef

The serine incorporator (SERINC) protein family has five paralogous members with 9–11 transmembrane domains. SERINC5 is a potent host restriction factor and antagonized by HIV-1 Nef and two other retroviral accessory proteins via the lysosomal degradation pathway. Here, we investigated human SERINC4...

Descripción completa

Detalles Bibliográficos
Autores principales:	Qiu, Xusheng, Eke, Ifeanyichukwu E., Johnson, Silas F., Ding, Chan, Zheng, Yong-Hui
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7842267/ https://www.ncbi.nlm.nih.gov/pubmed/33521797 http://dx.doi.org/10.1016/j.crviro.2020.100002

Ejemplares similares

Potent Enhancement of HIV-1 Replication by Nef in the Absence of SERINC3 and SERINC5
por: Wu, Yuanfei, et al.
Publicado: (2019)

Spotlight on HIV-1 Nef: SERINC3 and SERINC5 Identified as Restriction Factors Antagonized by the Pathogenesis Factor
por: Fackler, Oliver T.
Publicado: (2015)

Nef Obtained from Individuals with HIV-1 Vary in Their Ability to Antagonize SERINC3- and SERINC5-Mediated HIV-1 Restriction
por: Kruize, Zita, et al.
Publicado: (2021)

SERINC3 and SERINC5 restrict HIV-1 infectivity and are counteracted by Nef
por: Usami, Yoshiko, et al.
Publicado: (2015)

HIV-1 Nef interacts with the cyclin K/CDK13 complex to antagonize SERINC5 for optimal viral infectivity
por: Chai, Qingqing, et al.
Publicado: (2021)

Variation in HIV-1 Nef function within and among viral subtypes reveals genetically separable antagonism of SERINC3 and SERINC5
por: Jin, Steven W., et al.
Publicado: (2020)

Natural HIV-1 Nef Polymorphisms Impair SERINC5 Downregulation Activity
por: Jin, Steven W., et al.
Publicado: (2019)

SIVcol Nef counteracts SERINC5 by promoting its proteasomal degradation but does not efficiently enhance HIV-1 replication in human CD4+ T cells and lymphoid tissue
por: Kmiec, Dorota, et al.
Publicado: (2018)

HIV-1 subtype C Nef-mediated SERINC5 down-regulation significantly contributes to overall Nef activity
por: Naicker, Delon, et al.
Publicado: (2023)

Nef enhances HIV-1 replication and infectivity independently of SERINC5 in CEM T cells
por: Ramirez, Peter W., et al.
Publicado: (2023)

Cul3-KLHL20 E3 ubiquitin ligase plays a key role in the arms race between HIV-1 Nef and host SERINC5 restriction
por: Li, Sunan, et al.
Publicado: (2022)

Impaired ability of Nef to counteract SERINC5 is associated with reduced plasma viremia in HIV-infected individuals
por: Toyoda, Mako, et al.
Publicado: (2020)

Longitudinal within-host evolution of HIV Nef-mediated CD4, HLA and SERINC5 downregulation activity: a case study
por: Sudderuddin, Hanwei, et al.
Publicado: (2020)

AP-2 Adaptor Complex-Dependent Enhancement of HIV-1 Replication by Nef in the Absence of the Nef/AP-2 Targets SERINC5 and CD4
por: Olety, Balaji, et al.
Publicado: (2023)

SERINC5 Potently Restricts Retrovirus Infection In Vivo
por: Timilsina, Uddhav, et al.
Publicado: (2020)

HIV-1 restriction by SERINC5
por: Cano-Ortiz, Lucía, et al.
Publicado: (2022)

A Conserved Acidic Residue in the C-Terminal Flexible Loop of HIV-1 Nef Contributes to the Activity of SERINC5 and CD4 Downregulation
por: Firrito, Claudia, et al.
Publicado: (2023)

Novel monoclonal antibodies to the SERINC5 HIV-1 restriction factor detect endogenous and virion-associated SERINC5
por: Molnar, Sebastian, et al.
Publicado: (2020)

Characterization of Endogenous SERINC5 Protein as Anti-HIV-1 Factor
por: Passos, Vânia, et al.
Publicado: (2019)

SARS-CoV-2 ORF7a potently inhibits the antiviral effect of the host factor SERINC5
por: Timilsina, Uddhav, et al.
Publicado: (2022)

HIV-1 Group P is unable to antagonize human tetherin by Vpu, Env or Nef
por: Sauter, Daniel, et al.
Publicado: (2011)

Antiviral HIV-1 SERINC restriction factors disrupt virus membrane asymmetry
por: Leonhardt, Susan A., et al.
Publicado: (2023)

SERINC as a Restriction Factor to Inhibit Viral Infectivity and the Interaction with HIV
por: Gonzalez-Enriquez, Gracia Viviana, et al.
Publicado: (2017)

HIV envelope tail truncation confers resistance to SERINC5 restriction
por: Haider, Tafhima, et al.
Publicado: (2021)

Cell Surface Proteomic Map of HIV Infection Reveals Antagonism of Amino Acid Metabolism by Vpu and Nef
por: Matheson, Nicholas J., et al.
Publicado: (2015)

Tetherin/BST-2 Antagonism by Nef Depends on a Direct Physical Interaction between Nef and Tetherin, and on Clathrin-mediated Endocytosis
por: Serra-Moreno, Ruth, et al.
Publicado: (2013)

HIV-1 Nef targets calnexin: a novel mechanism behind Nef effects on host cell and viral proteins
por: Jennelle, Lucas, et al.
Publicado: (2013)

HIV-1 Impairment via UBE3A and HIV-1 Nef Interactions Utilizing the Ubiquitin Proteasome System
por: Pyeon, Dohun, et al.
Publicado: (2019)

SERINC5 restricts influenza virus infectivity
por: Zhao, Fei, et al.
Publicado: (2022)

Restriction of Influenza A Virus by SERINC5
por: Lai, Kin Kui, et al.
Publicado: (2022)

HIV-1 Nef: at the crossroads
por: Foster, John L, et al.
Publicado: (2008)

A bipartite structural organization defines the SERINC family of HIV-1 restriction factors
por: Pye, Valerie E., et al.
Publicado: (2020)

SERINC5 Mediates a Postintegration Block to HIV-1 Gene Expression in Macrophages
por: Ramdas, Pavitra, et al.
Publicado: (2023)

In-silico designing of a potent analogue against HIV-1 Nef protein and protease by predicting its interaction network with host cell proteins
por: Pal, Shikha, et al.
Publicado: (2013)

HIV-1 antagonism of CD317/tetherin is species-specific and involves Vpu-mediated proteasomal degradation of the intrinsic immunity factor
por: Goffinet, Christine, et al.
Publicado: (2009)

HIV Preintegration Transcription and Host Antagonism
por: Wu, Yuntao
Publicado: (2023)

Proteasome-mediated degradation antagonizes critical levels of the apoptosis-inducing C1D protein
por: Rothbarth, Karsten, et al.
Publicado: (2002)

The activity of Nef on HIV-1 infectivity
por: Basmaciogullari, Stéphane, et al.
Publicado: (2014)

SIV Nef Proteins Recruit the AP-2 Complex to Antagonize Tetherin and Facilitate Virion Release
por: Zhang, Fengwen, et al.
Publicado: (2011)

Loss of tetherin antagonism by Nef impairs SIV replication during acute infection of rhesus macaques
por: Tavakoli-Tameh, Aidin, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_i3gljdecj5mrno7gmfl2tseicg