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BLID: A Novel Tumor-Suppressor Gene

BLID (BH3-like motif containing, cell death inducer), also known as breast cancer cell 2 (BRCC2), was first reported in the human breast cancer cell line in 2004. BLID is a BH3-like motif containing apoptotic member of the Bcl-2 family. Recently, the BLID tumor-suppressor roles have been fully estab...

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Detalles Bibliográficos
Autores principales: Yu, Xin, Li, Zheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cognizant Communication Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7842511/
https://www.ncbi.nlm.nih.gov/pubmed/26629946
http://dx.doi.org/10.3727/096504015X14410238486568
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author Yu, Xin
Li, Zheng
author_facet Yu, Xin
Li, Zheng
author_sort Yu, Xin
collection PubMed
description BLID (BH3-like motif containing, cell death inducer), also known as breast cancer cell 2 (BRCC2), was first reported in the human breast cancer cell line in 2004. BLID is a BH3-like motif containing apoptotic member of the Bcl-2 family. Recently, the BLID tumor-suppressor roles have been fully established. Several studies have found that BLID is frequently downregulated in many human cancers and the downregulation is often associated with tumor progression. Multivariate analysis indicated that BLID is an independent prognostic factor for overall survival and distant metastasis-free survival. Moreover, BLID can inhibit breast cancer cell growth and metastasis and promote apoptosis. BLID can regulate the expression of various tumor-related genes and proteins, such as AKT and MMP. In this review, we provide an overview of current knowledge concerning the role of BLID in tumor development and progression. To our knowledge, this is the first review about the role of this novel tumor-suppressor gene in tumor development and progression.
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spelling pubmed-78425112021-02-16 BLID: A Novel Tumor-Suppressor Gene Yu, Xin Li, Zheng Oncol Res Review BLID (BH3-like motif containing, cell death inducer), also known as breast cancer cell 2 (BRCC2), was first reported in the human breast cancer cell line in 2004. BLID is a BH3-like motif containing apoptotic member of the Bcl-2 family. Recently, the BLID tumor-suppressor roles have been fully established. Several studies have found that BLID is frequently downregulated in many human cancers and the downregulation is often associated with tumor progression. Multivariate analysis indicated that BLID is an independent prognostic factor for overall survival and distant metastasis-free survival. Moreover, BLID can inhibit breast cancer cell growth and metastasis and promote apoptosis. BLID can regulate the expression of various tumor-related genes and proteins, such as AKT and MMP. In this review, we provide an overview of current knowledge concerning the role of BLID in tumor development and progression. To our knowledge, this is the first review about the role of this novel tumor-suppressor gene in tumor development and progression. Cognizant Communication Corporation 2015-11-25 /pmc/articles/PMC7842511/ /pubmed/26629946 http://dx.doi.org/10.3727/096504015X14410238486568 Text en Copyright © 2015 Cognizant Comm. Corp. http://creativecommons.org/licenses/by-nc-nd/4.0/ This article is licensed under a Creative Commons Attribution-NonCommercial NoDerivatives 4.0 International License.
spellingShingle Review
Yu, Xin
Li, Zheng
BLID: A Novel Tumor-Suppressor Gene
title BLID: A Novel Tumor-Suppressor Gene
title_full BLID: A Novel Tumor-Suppressor Gene
title_fullStr BLID: A Novel Tumor-Suppressor Gene
title_full_unstemmed BLID: A Novel Tumor-Suppressor Gene
title_short BLID: A Novel Tumor-Suppressor Gene
title_sort blid: a novel tumor-suppressor gene
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7842511/
https://www.ncbi.nlm.nih.gov/pubmed/26629946
http://dx.doi.org/10.3727/096504015X14410238486568
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