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A One Health approach to assessing occupational exposure to antimicrobial resistance in Thailand: The FarmResist project

This Southeast Asia-Europe research project will use a One Health approach to identify the major parameters responsible for the presence of animal-associated antimicrobial resistant bacteria in animal production facilities in Thailand and the risk of their transmission from animals to humans. We wil...

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Autores principales: Sudatip, Duangdao, Chasiri, Kittipong, Kritiyakan, Anamika, Phanprasit, Wantanee, Thinphovong, Chuanphot, Tiengrim, Surapee, Thamlikitkul, Visanu, Abdallah, Rim, Baron, Sophie Alexandra, Rolain, Jean-Marc, Morand, Serge, Hilty, Markus, Oppliger, Anne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7842938/
https://www.ncbi.nlm.nih.gov/pubmed/33507909
http://dx.doi.org/10.1371/journal.pone.0245250
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author Sudatip, Duangdao
Chasiri, Kittipong
Kritiyakan, Anamika
Phanprasit, Wantanee
Thinphovong, Chuanphot
Tiengrim, Surapee
Thamlikitkul, Visanu
Abdallah, Rim
Baron, Sophie Alexandra
Rolain, Jean-Marc
Morand, Serge
Hilty, Markus
Oppliger, Anne
author_facet Sudatip, Duangdao
Chasiri, Kittipong
Kritiyakan, Anamika
Phanprasit, Wantanee
Thinphovong, Chuanphot
Tiengrim, Surapee
Thamlikitkul, Visanu
Abdallah, Rim
Baron, Sophie Alexandra
Rolain, Jean-Marc
Morand, Serge
Hilty, Markus
Oppliger, Anne
author_sort Sudatip, Duangdao
collection PubMed
description This Southeast Asia-Europe research project will use a One Health approach to identify the major parameters responsible for the presence of animal-associated antimicrobial resistant bacteria in animal production facilities in Thailand and the risk of their transmission from animals to humans. We will focus on traditional, small, extensive pig and poultry farms where information on antibiotic use is scarce and animals live in close contact with humans. This cross-sectional study will be based on the epidemiological analysis of the antimicrobial resistance (AMR) present in fecal samples from animals and humans. Extended spectrum beta-lactamase producing Enterobacteriaceae (ESBL-E) and Enterobacteriaceae resistant to colistin will be actively searched in the feces of farm animals (pigs and poultry), small wild rodents and farmers. Phenotypic (selective plating) and genotypic (multilocus seuquence typing and sequencing) methods will be used for the detection of AMR, the identification of antibiotic resistance genes (ARGs) and the characterization of strains carrying resistance genes. Questionnaires will be administered to investigate the effects of antibiotic use, farm characteristics and biosecurity measures on the occurrence of AMR in animals. Subsequently, the fecal carriage of AMR and ARGs in farmers will be compared to a control population with no occupational contacts with animals, thus enabling an estimation of the risk of transmission of AMR/ARGs from animals to farmers.
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spelling pubmed-78429382021-02-04 A One Health approach to assessing occupational exposure to antimicrobial resistance in Thailand: The FarmResist project Sudatip, Duangdao Chasiri, Kittipong Kritiyakan, Anamika Phanprasit, Wantanee Thinphovong, Chuanphot Tiengrim, Surapee Thamlikitkul, Visanu Abdallah, Rim Baron, Sophie Alexandra Rolain, Jean-Marc Morand, Serge Hilty, Markus Oppliger, Anne PLoS One Registered Report Protocol This Southeast Asia-Europe research project will use a One Health approach to identify the major parameters responsible for the presence of animal-associated antimicrobial resistant bacteria in animal production facilities in Thailand and the risk of their transmission from animals to humans. We will focus on traditional, small, extensive pig and poultry farms where information on antibiotic use is scarce and animals live in close contact with humans. This cross-sectional study will be based on the epidemiological analysis of the antimicrobial resistance (AMR) present in fecal samples from animals and humans. Extended spectrum beta-lactamase producing Enterobacteriaceae (ESBL-E) and Enterobacteriaceae resistant to colistin will be actively searched in the feces of farm animals (pigs and poultry), small wild rodents and farmers. Phenotypic (selective plating) and genotypic (multilocus seuquence typing and sequencing) methods will be used for the detection of AMR, the identification of antibiotic resistance genes (ARGs) and the characterization of strains carrying resistance genes. Questionnaires will be administered to investigate the effects of antibiotic use, farm characteristics and biosecurity measures on the occurrence of AMR in animals. Subsequently, the fecal carriage of AMR and ARGs in farmers will be compared to a control population with no occupational contacts with animals, thus enabling an estimation of the risk of transmission of AMR/ARGs from animals to farmers. Public Library of Science 2021-01-28 /pmc/articles/PMC7842938/ /pubmed/33507909 http://dx.doi.org/10.1371/journal.pone.0245250 Text en © 2021 Sudatip et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Registered Report Protocol
Sudatip, Duangdao
Chasiri, Kittipong
Kritiyakan, Anamika
Phanprasit, Wantanee
Thinphovong, Chuanphot
Tiengrim, Surapee
Thamlikitkul, Visanu
Abdallah, Rim
Baron, Sophie Alexandra
Rolain, Jean-Marc
Morand, Serge
Hilty, Markus
Oppliger, Anne
A One Health approach to assessing occupational exposure to antimicrobial resistance in Thailand: The FarmResist project
title A One Health approach to assessing occupational exposure to antimicrobial resistance in Thailand: The FarmResist project
title_full A One Health approach to assessing occupational exposure to antimicrobial resistance in Thailand: The FarmResist project
title_fullStr A One Health approach to assessing occupational exposure to antimicrobial resistance in Thailand: The FarmResist project
title_full_unstemmed A One Health approach to assessing occupational exposure to antimicrobial resistance in Thailand: The FarmResist project
title_short A One Health approach to assessing occupational exposure to antimicrobial resistance in Thailand: The FarmResist project
title_sort one health approach to assessing occupational exposure to antimicrobial resistance in thailand: the farmresist project
topic Registered Report Protocol
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7842938/
https://www.ncbi.nlm.nih.gov/pubmed/33507909
http://dx.doi.org/10.1371/journal.pone.0245250
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