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A One Health approach to assessing occupational exposure to antimicrobial resistance in Thailand: The FarmResist project
This Southeast Asia-Europe research project will use a One Health approach to identify the major parameters responsible for the presence of animal-associated antimicrobial resistant bacteria in animal production facilities in Thailand and the risk of their transmission from animals to humans. We wil...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7842938/ https://www.ncbi.nlm.nih.gov/pubmed/33507909 http://dx.doi.org/10.1371/journal.pone.0245250 |
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author | Sudatip, Duangdao Chasiri, Kittipong Kritiyakan, Anamika Phanprasit, Wantanee Thinphovong, Chuanphot Tiengrim, Surapee Thamlikitkul, Visanu Abdallah, Rim Baron, Sophie Alexandra Rolain, Jean-Marc Morand, Serge Hilty, Markus Oppliger, Anne |
author_facet | Sudatip, Duangdao Chasiri, Kittipong Kritiyakan, Anamika Phanprasit, Wantanee Thinphovong, Chuanphot Tiengrim, Surapee Thamlikitkul, Visanu Abdallah, Rim Baron, Sophie Alexandra Rolain, Jean-Marc Morand, Serge Hilty, Markus Oppliger, Anne |
author_sort | Sudatip, Duangdao |
collection | PubMed |
description | This Southeast Asia-Europe research project will use a One Health approach to identify the major parameters responsible for the presence of animal-associated antimicrobial resistant bacteria in animal production facilities in Thailand and the risk of their transmission from animals to humans. We will focus on traditional, small, extensive pig and poultry farms where information on antibiotic use is scarce and animals live in close contact with humans. This cross-sectional study will be based on the epidemiological analysis of the antimicrobial resistance (AMR) present in fecal samples from animals and humans. Extended spectrum beta-lactamase producing Enterobacteriaceae (ESBL-E) and Enterobacteriaceae resistant to colistin will be actively searched in the feces of farm animals (pigs and poultry), small wild rodents and farmers. Phenotypic (selective plating) and genotypic (multilocus seuquence typing and sequencing) methods will be used for the detection of AMR, the identification of antibiotic resistance genes (ARGs) and the characterization of strains carrying resistance genes. Questionnaires will be administered to investigate the effects of antibiotic use, farm characteristics and biosecurity measures on the occurrence of AMR in animals. Subsequently, the fecal carriage of AMR and ARGs in farmers will be compared to a control population with no occupational contacts with animals, thus enabling an estimation of the risk of transmission of AMR/ARGs from animals to farmers. |
format | Online Article Text |
id | pubmed-7842938 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-78429382021-02-04 A One Health approach to assessing occupational exposure to antimicrobial resistance in Thailand: The FarmResist project Sudatip, Duangdao Chasiri, Kittipong Kritiyakan, Anamika Phanprasit, Wantanee Thinphovong, Chuanphot Tiengrim, Surapee Thamlikitkul, Visanu Abdallah, Rim Baron, Sophie Alexandra Rolain, Jean-Marc Morand, Serge Hilty, Markus Oppliger, Anne PLoS One Registered Report Protocol This Southeast Asia-Europe research project will use a One Health approach to identify the major parameters responsible for the presence of animal-associated antimicrobial resistant bacteria in animal production facilities in Thailand and the risk of their transmission from animals to humans. We will focus on traditional, small, extensive pig and poultry farms where information on antibiotic use is scarce and animals live in close contact with humans. This cross-sectional study will be based on the epidemiological analysis of the antimicrobial resistance (AMR) present in fecal samples from animals and humans. Extended spectrum beta-lactamase producing Enterobacteriaceae (ESBL-E) and Enterobacteriaceae resistant to colistin will be actively searched in the feces of farm animals (pigs and poultry), small wild rodents and farmers. Phenotypic (selective plating) and genotypic (multilocus seuquence typing and sequencing) methods will be used for the detection of AMR, the identification of antibiotic resistance genes (ARGs) and the characterization of strains carrying resistance genes. Questionnaires will be administered to investigate the effects of antibiotic use, farm characteristics and biosecurity measures on the occurrence of AMR in animals. Subsequently, the fecal carriage of AMR and ARGs in farmers will be compared to a control population with no occupational contacts with animals, thus enabling an estimation of the risk of transmission of AMR/ARGs from animals to farmers. Public Library of Science 2021-01-28 /pmc/articles/PMC7842938/ /pubmed/33507909 http://dx.doi.org/10.1371/journal.pone.0245250 Text en © 2021 Sudatip et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Registered Report Protocol Sudatip, Duangdao Chasiri, Kittipong Kritiyakan, Anamika Phanprasit, Wantanee Thinphovong, Chuanphot Tiengrim, Surapee Thamlikitkul, Visanu Abdallah, Rim Baron, Sophie Alexandra Rolain, Jean-Marc Morand, Serge Hilty, Markus Oppliger, Anne A One Health approach to assessing occupational exposure to antimicrobial resistance in Thailand: The FarmResist project |
title | A One Health approach to assessing occupational exposure to antimicrobial resistance in Thailand: The FarmResist project |
title_full | A One Health approach to assessing occupational exposure to antimicrobial resistance in Thailand: The FarmResist project |
title_fullStr | A One Health approach to assessing occupational exposure to antimicrobial resistance in Thailand: The FarmResist project |
title_full_unstemmed | A One Health approach to assessing occupational exposure to antimicrobial resistance in Thailand: The FarmResist project |
title_short | A One Health approach to assessing occupational exposure to antimicrobial resistance in Thailand: The FarmResist project |
title_sort | one health approach to assessing occupational exposure to antimicrobial resistance in thailand: the farmresist project |
topic | Registered Report Protocol |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7842938/ https://www.ncbi.nlm.nih.gov/pubmed/33507909 http://dx.doi.org/10.1371/journal.pone.0245250 |
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