Functional analyses of epidemic Clostridioides difficile toxin B variants reveal their divergence in utilizing receptors and inducing pathology

Clostridioides difficile toxin B (TcdB) is a key virulence factor that causes C. difficile associated diseases (CDAD) including diarrhea and pseudomembranous colitis. TcdB can be divided into multiple subtypes/variants based on their sequence variations, of which four (TcdB1-4) are dominant types fo...

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Detalles Bibliográficos
Autores principales: Pan, Zhenrui, Zhang, Yuanyuan, Luo, Jianhua, Li, Danyang, Zhou, Yao, He, Liuqing, Yang, Qi, Dong, Min, Tao, Liang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7842947/
https://www.ncbi.nlm.nih.gov/pubmed/33507919
http://dx.doi.org/10.1371/journal.ppat.1009197

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