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Loss of a co-twin at birth and subsequent risk of psychiatric disorders

Twins suffering a co-twin loss at birth have reported feelings of loneliness and grief while it remains unexplored if they suffer increased risk of psychiatric disorders. We contrasted rate of first-onset psychiatric disorders among all Swedish-born twins whose co-twin died within 60 days after birt...

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Autores principales: Song, Huan, Fang, Fang, Larsson, Henrik, Pedersen, Nancy L, Magnusson, Patrik KE, Almqvist, Catarina, Valdimarsdóttir, Unnur A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7843130/
https://www.ncbi.nlm.nih.gov/pubmed/33507148
http://dx.doi.org/10.7554/eLife.63514
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author Song, Huan
Fang, Fang
Larsson, Henrik
Pedersen, Nancy L
Magnusson, Patrik KE
Almqvist, Catarina
Valdimarsdóttir, Unnur A
author_facet Song, Huan
Fang, Fang
Larsson, Henrik
Pedersen, Nancy L
Magnusson, Patrik KE
Almqvist, Catarina
Valdimarsdóttir, Unnur A
author_sort Song, Huan
collection PubMed
description Twins suffering a co-twin loss at birth have reported feelings of loneliness and grief while it remains unexplored if they suffer increased risk of psychiatric disorders. We contrasted rate of first-onset psychiatric disorders among all Swedish-born twins whose co-twin died within 60 days after birth between 1973 and 2011 (n = 787) to that of 3935 matched unexposed twins, 3935 matched singletons (both matched to the exposed twins by birth year, sex, and birth characteristics), and 880 full siblings of the exposed twins. During a median of 19-year follow-up, exposed twins were at increased risk of first-onset psychiatric disorders (hazard ratio = 1.56, 95%CI 1.30–1.87) compared with unexposed twins. We observed the strongest association for emotional disorders and for psychiatric disorders diagnosed before the age of 25. Comparisons with matched singletons and the twin’s full siblings rendered similar results, corroborating an association of loss of a co-twin at birth with subsequent risk of psychiatric disorders.
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spelling pubmed-78431302021-02-01 Loss of a co-twin at birth and subsequent risk of psychiatric disorders Song, Huan Fang, Fang Larsson, Henrik Pedersen, Nancy L Magnusson, Patrik KE Almqvist, Catarina Valdimarsdóttir, Unnur A eLife Epidemiology and Global Health Twins suffering a co-twin loss at birth have reported feelings of loneliness and grief while it remains unexplored if they suffer increased risk of psychiatric disorders. We contrasted rate of first-onset psychiatric disorders among all Swedish-born twins whose co-twin died within 60 days after birth between 1973 and 2011 (n = 787) to that of 3935 matched unexposed twins, 3935 matched singletons (both matched to the exposed twins by birth year, sex, and birth characteristics), and 880 full siblings of the exposed twins. During a median of 19-year follow-up, exposed twins were at increased risk of first-onset psychiatric disorders (hazard ratio = 1.56, 95%CI 1.30–1.87) compared with unexposed twins. We observed the strongest association for emotional disorders and for psychiatric disorders diagnosed before the age of 25. Comparisons with matched singletons and the twin’s full siblings rendered similar results, corroborating an association of loss of a co-twin at birth with subsequent risk of psychiatric disorders. eLife Sciences Publications, Ltd 2021-01-28 /pmc/articles/PMC7843130/ /pubmed/33507148 http://dx.doi.org/10.7554/eLife.63514 Text en © 2021, Song et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Epidemiology and Global Health
Song, Huan
Fang, Fang
Larsson, Henrik
Pedersen, Nancy L
Magnusson, Patrik KE
Almqvist, Catarina
Valdimarsdóttir, Unnur A
Loss of a co-twin at birth and subsequent risk of psychiatric disorders
title Loss of a co-twin at birth and subsequent risk of psychiatric disorders
title_full Loss of a co-twin at birth and subsequent risk of psychiatric disorders
title_fullStr Loss of a co-twin at birth and subsequent risk of psychiatric disorders
title_full_unstemmed Loss of a co-twin at birth and subsequent risk of psychiatric disorders
title_short Loss of a co-twin at birth and subsequent risk of psychiatric disorders
title_sort loss of a co-twin at birth and subsequent risk of psychiatric disorders
topic Epidemiology and Global Health
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7843130/
https://www.ncbi.nlm.nih.gov/pubmed/33507148
http://dx.doi.org/10.7554/eLife.63514
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