Cargando…
Long noncoding RNA plasmacytoma variant translocation gene 1 promotes epithelial‐mesenchymal transition in osteosarcoma
OBJECTIVE: Long noncoding RNAs (lncRNAs) are involved in the proliferation, migration, and invasion of tumors. In the current study, our aim was to explore the role of lncRNA plasmacytoma variant translocation gene 1 (PVT1) in osteosarcoma. METHODS: Quantitative real‐time reverse transcription‐polym...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7843291/ https://www.ncbi.nlm.nih.gov/pubmed/32960485 http://dx.doi.org/10.1002/jcla.23587 |
_version_ | 1783644114327175168 |
---|---|
author | Xun, Chuanhui Jiang, Dawei Tian, Zheng Yunus, Akbar Chen, Jiangtao |
author_facet | Xun, Chuanhui Jiang, Dawei Tian, Zheng Yunus, Akbar Chen, Jiangtao |
author_sort | Xun, Chuanhui |
collection | PubMed |
description | OBJECTIVE: Long noncoding RNAs (lncRNAs) are involved in the proliferation, migration, and invasion of tumors. In the current study, our aim was to explore the role of lncRNA plasmacytoma variant translocation gene 1 (PVT1) in osteosarcoma. METHODS: Quantitative real‐time reverse transcription‐polymerase chain reaction was used to detect the expression of lncRNA PVT1 in osteosarcoma tissues and cells. The relationship between lncRNA PVT1 expression status and the prognosis of patients with osteosarcoma was analyzed. The effect of lncRNA PVT1 on the malignant biological behavior of osteosarcoma cells in vitro was also analyzed. RESULTS: LncRNA PVT1 was upregulated in osteosarcoma. High lncRNA PVT1 expression indicated poor prognosis in patients with osteosarcoma. In vitro knockdown of lncRNA PVT1 inhibited the proliferation, migration, and invasion ability of osteosarcoma cells. In addition, we confirmed that lncRNA PVT1 affected the epithelial‐mesenchymal transition of osteosarcoma cells. CONCLUSION: LncRNA PVT1 is a potential therapeutic target for osteosarcoma. |
format | Online Article Text |
id | pubmed-7843291 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-78432912021-02-02 Long noncoding RNA plasmacytoma variant translocation gene 1 promotes epithelial‐mesenchymal transition in osteosarcoma Xun, Chuanhui Jiang, Dawei Tian, Zheng Yunus, Akbar Chen, Jiangtao J Clin Lab Anal Research Articles OBJECTIVE: Long noncoding RNAs (lncRNAs) are involved in the proliferation, migration, and invasion of tumors. In the current study, our aim was to explore the role of lncRNA plasmacytoma variant translocation gene 1 (PVT1) in osteosarcoma. METHODS: Quantitative real‐time reverse transcription‐polymerase chain reaction was used to detect the expression of lncRNA PVT1 in osteosarcoma tissues and cells. The relationship between lncRNA PVT1 expression status and the prognosis of patients with osteosarcoma was analyzed. The effect of lncRNA PVT1 on the malignant biological behavior of osteosarcoma cells in vitro was also analyzed. RESULTS: LncRNA PVT1 was upregulated in osteosarcoma. High lncRNA PVT1 expression indicated poor prognosis in patients with osteosarcoma. In vitro knockdown of lncRNA PVT1 inhibited the proliferation, migration, and invasion ability of osteosarcoma cells. In addition, we confirmed that lncRNA PVT1 affected the epithelial‐mesenchymal transition of osteosarcoma cells. CONCLUSION: LncRNA PVT1 is a potential therapeutic target for osteosarcoma. John Wiley and Sons Inc. 2020-09-22 /pmc/articles/PMC7843291/ /pubmed/32960485 http://dx.doi.org/10.1002/jcla.23587 Text en © 2020 The Authors. Journal of Clinical Laboratory Analysis Published by Wiley Periodicals LLC This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Articles Xun, Chuanhui Jiang, Dawei Tian, Zheng Yunus, Akbar Chen, Jiangtao Long noncoding RNA plasmacytoma variant translocation gene 1 promotes epithelial‐mesenchymal transition in osteosarcoma |
title | Long noncoding RNA plasmacytoma variant translocation gene 1 promotes epithelial‐mesenchymal transition in osteosarcoma |
title_full | Long noncoding RNA plasmacytoma variant translocation gene 1 promotes epithelial‐mesenchymal transition in osteosarcoma |
title_fullStr | Long noncoding RNA plasmacytoma variant translocation gene 1 promotes epithelial‐mesenchymal transition in osteosarcoma |
title_full_unstemmed | Long noncoding RNA plasmacytoma variant translocation gene 1 promotes epithelial‐mesenchymal transition in osteosarcoma |
title_short | Long noncoding RNA plasmacytoma variant translocation gene 1 promotes epithelial‐mesenchymal transition in osteosarcoma |
title_sort | long noncoding rna plasmacytoma variant translocation gene 1 promotes epithelial‐mesenchymal transition in osteosarcoma |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7843291/ https://www.ncbi.nlm.nih.gov/pubmed/32960485 http://dx.doi.org/10.1002/jcla.23587 |
work_keys_str_mv | AT xunchuanhui longnoncodingrnaplasmacytomavarianttranslocationgene1promotesepithelialmesenchymaltransitioninosteosarcoma AT jiangdawei longnoncodingrnaplasmacytomavarianttranslocationgene1promotesepithelialmesenchymaltransitioninosteosarcoma AT tianzheng longnoncodingrnaplasmacytomavarianttranslocationgene1promotesepithelialmesenchymaltransitioninosteosarcoma AT yunusakbar longnoncodingrnaplasmacytomavarianttranslocationgene1promotesepithelialmesenchymaltransitioninosteosarcoma AT chenjiangtao longnoncodingrnaplasmacytomavarianttranslocationgene1promotesepithelialmesenchymaltransitioninosteosarcoma |