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IL-21 arming potentiates the anti-tumor activity of an oncolytic vaccinia virus in monotherapy and combination therapy

BACKGROUND: Oncolytic viruses (OVs) have shown promise in containing cancer progression in both animal models and clinical trials. How to further improve the efficacy of OVs are intensively explored. Arming OVs with immunoregulatory molecules has emerged as an important means to enhance their oncoly...

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Detalles Bibliográficos
Autores principales:	Chen, Tianyue, Ding, Xiangqing, Liao, Qibin, Gao, Nan, Chen, Ye, Zhao, Chen, Zhang, Xiaoyan, Xu, Jianqing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2021
Materias:	Oncolytic and Local Immunotherapy
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7843316/ https://www.ncbi.nlm.nih.gov/pubmed/33504576 http://dx.doi.org/10.1136/jitc-2020-001647

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