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Effect of significant weight loss on disease activity: reason to implement this non-pharmaceutical intervention in daily clinical practice
Obesity is very common in patients with inflammatory rheumatic diseases (IRDs), of which between 27% and 37% of patients have a body mass index ≥30 kg/m(2). In addition to further increasing the risk of developing cardiovascular diseases (CVDs) in this group of patients, obesity is associated with h...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7843325/ https://www.ncbi.nlm.nih.gov/pubmed/33504577 http://dx.doi.org/10.1136/rmdopen-2020-001498 |
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author | Weijers, Julia M Müskens, Wieland D van Riel, Piet L C M |
author_facet | Weijers, Julia M Müskens, Wieland D van Riel, Piet L C M |
author_sort | Weijers, Julia M |
collection | PubMed |
description | Obesity is very common in patients with inflammatory rheumatic diseases (IRDs), of which between 27% and 37% of patients have a body mass index ≥30 kg/m(2). In addition to further increasing the risk of developing cardiovascular diseases (CVDs) in this group of patients, obesity is associated with higher disease activity and a lower response to drug therapy. This case series showed that in those patients with rheumatoid arthritis or psoriatic arthritis with a substantial weight loss of >10% of body mass, median Disease Activity Score 28 joints score decreased with 0.9. This reduction in disease activity resulted in an increase in the percentage of patients achieving remission from 6% to 63%. This reduction in disease activity was obtained without intensification of medical treatment in 87% of the patients. This case series supports the current evidence that weight reduction has positive effects on the course of the disease and thus also on the CVD risk profile in these patients. Therefore, weight loss can serve as a non-pharmacological treatment option in obese patients with IRDs. |
format | Online Article Text |
id | pubmed-7843325 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-78433252021-01-29 Effect of significant weight loss on disease activity: reason to implement this non-pharmaceutical intervention in daily clinical practice Weijers, Julia M Müskens, Wieland D van Riel, Piet L C M RMD Open Inflammatory Arthritis Obesity is very common in patients with inflammatory rheumatic diseases (IRDs), of which between 27% and 37% of patients have a body mass index ≥30 kg/m(2). In addition to further increasing the risk of developing cardiovascular diseases (CVDs) in this group of patients, obesity is associated with higher disease activity and a lower response to drug therapy. This case series showed that in those patients with rheumatoid arthritis or psoriatic arthritis with a substantial weight loss of >10% of body mass, median Disease Activity Score 28 joints score decreased with 0.9. This reduction in disease activity resulted in an increase in the percentage of patients achieving remission from 6% to 63%. This reduction in disease activity was obtained without intensification of medical treatment in 87% of the patients. This case series supports the current evidence that weight reduction has positive effects on the course of the disease and thus also on the CVD risk profile in these patients. Therefore, weight loss can serve as a non-pharmacological treatment option in obese patients with IRDs. BMJ Publishing Group 2021-01-27 /pmc/articles/PMC7843325/ /pubmed/33504577 http://dx.doi.org/10.1136/rmdopen-2020-001498 Text en © Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/ http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/. |
spellingShingle | Inflammatory Arthritis Weijers, Julia M Müskens, Wieland D van Riel, Piet L C M Effect of significant weight loss on disease activity: reason to implement this non-pharmaceutical intervention in daily clinical practice |
title | Effect of significant weight loss on disease activity: reason to implement this non-pharmaceutical intervention in daily clinical practice |
title_full | Effect of significant weight loss on disease activity: reason to implement this non-pharmaceutical intervention in daily clinical practice |
title_fullStr | Effect of significant weight loss on disease activity: reason to implement this non-pharmaceutical intervention in daily clinical practice |
title_full_unstemmed | Effect of significant weight loss on disease activity: reason to implement this non-pharmaceutical intervention in daily clinical practice |
title_short | Effect of significant weight loss on disease activity: reason to implement this non-pharmaceutical intervention in daily clinical practice |
title_sort | effect of significant weight loss on disease activity: reason to implement this non-pharmaceutical intervention in daily clinical practice |
topic | Inflammatory Arthritis |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7843325/ https://www.ncbi.nlm.nih.gov/pubmed/33504577 http://dx.doi.org/10.1136/rmdopen-2020-001498 |
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