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Effect of significant weight loss on disease activity: reason to implement this non-pharmaceutical intervention in daily clinical practice

Obesity is very common in patients with inflammatory rheumatic diseases (IRDs), of which between 27% and 37% of patients have a body mass index ≥30 kg/m(2). In addition to further increasing the risk of developing cardiovascular diseases (CVDs) in this group of patients, obesity is associated with h...

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Autores principales: Weijers, Julia M, Müskens, Wieland D, van Riel, Piet L C M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7843325/
https://www.ncbi.nlm.nih.gov/pubmed/33504577
http://dx.doi.org/10.1136/rmdopen-2020-001498
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author Weijers, Julia M
Müskens, Wieland D
van Riel, Piet L C M
author_facet Weijers, Julia M
Müskens, Wieland D
van Riel, Piet L C M
author_sort Weijers, Julia M
collection PubMed
description Obesity is very common in patients with inflammatory rheumatic diseases (IRDs), of which between 27% and 37% of patients have a body mass index ≥30 kg/m(2). In addition to further increasing the risk of developing cardiovascular diseases (CVDs) in this group of patients, obesity is associated with higher disease activity and a lower response to drug therapy. This case series showed that in those patients with rheumatoid arthritis or psoriatic arthritis with a substantial weight loss of >10% of body mass, median Disease Activity Score 28 joints score decreased with 0.9. This reduction in disease activity resulted in an increase in the percentage of patients achieving remission from 6% to 63%. This reduction in disease activity was obtained without intensification of medical treatment in 87% of the patients. This case series supports the current evidence that weight reduction has positive effects on the course of the disease and thus also on the CVD risk profile in these patients. Therefore, weight loss can serve as a non-pharmacological treatment option in obese patients with IRDs.
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spelling pubmed-78433252021-01-29 Effect of significant weight loss on disease activity: reason to implement this non-pharmaceutical intervention in daily clinical practice Weijers, Julia M Müskens, Wieland D van Riel, Piet L C M RMD Open Inflammatory Arthritis Obesity is very common in patients with inflammatory rheumatic diseases (IRDs), of which between 27% and 37% of patients have a body mass index ≥30 kg/m(2). In addition to further increasing the risk of developing cardiovascular diseases (CVDs) in this group of patients, obesity is associated with higher disease activity and a lower response to drug therapy. This case series showed that in those patients with rheumatoid arthritis or psoriatic arthritis with a substantial weight loss of >10% of body mass, median Disease Activity Score 28 joints score decreased with 0.9. This reduction in disease activity resulted in an increase in the percentage of patients achieving remission from 6% to 63%. This reduction in disease activity was obtained without intensification of medical treatment in 87% of the patients. This case series supports the current evidence that weight reduction has positive effects on the course of the disease and thus also on the CVD risk profile in these patients. Therefore, weight loss can serve as a non-pharmacological treatment option in obese patients with IRDs. BMJ Publishing Group 2021-01-27 /pmc/articles/PMC7843325/ /pubmed/33504577 http://dx.doi.org/10.1136/rmdopen-2020-001498 Text en © Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/ http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Inflammatory Arthritis
Weijers, Julia M
Müskens, Wieland D
van Riel, Piet L C M
Effect of significant weight loss on disease activity: reason to implement this non-pharmaceutical intervention in daily clinical practice
title Effect of significant weight loss on disease activity: reason to implement this non-pharmaceutical intervention in daily clinical practice
title_full Effect of significant weight loss on disease activity: reason to implement this non-pharmaceutical intervention in daily clinical practice
title_fullStr Effect of significant weight loss on disease activity: reason to implement this non-pharmaceutical intervention in daily clinical practice
title_full_unstemmed Effect of significant weight loss on disease activity: reason to implement this non-pharmaceutical intervention in daily clinical practice
title_short Effect of significant weight loss on disease activity: reason to implement this non-pharmaceutical intervention in daily clinical practice
title_sort effect of significant weight loss on disease activity: reason to implement this non-pharmaceutical intervention in daily clinical practice
topic Inflammatory Arthritis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7843325/
https://www.ncbi.nlm.nih.gov/pubmed/33504577
http://dx.doi.org/10.1136/rmdopen-2020-001498
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