TIPE1 Promotes Cervical Cancer Cell Chemoresistance to Cisplatin in a Wild-Type p53-Dependent Manner

Previous studies have revealed that TIPE1 serves as a tumor suppressor gene in several tumor types. However, we demonstrated that TIPE1 can promote cervical cancer proliferation by suppressing p53 activity. Here, we showed that TIPE1 inhibits cervical cancer cell apoptosis both in vivo and in vitro....

Descripción completa

Detalles Bibliográficos
Autores principales: Jiang, Jie, Gao, Li, Lan, Yongting, Wang, Yang, Zhao, Peiqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7843385/
https://www.ncbi.nlm.nih.gov/pubmed/33520705
http://dx.doi.org/10.3389/fonc.2020.593615
_version_ 1783644129291403264
author Jiang, Jie
Gao, Li
Lan, Yongting
Wang, Yang
Zhao, Peiqing
author_facet Jiang, Jie
Gao, Li
Lan, Yongting
Wang, Yang
Zhao, Peiqing
author_sort Jiang, Jie
collection PubMed
description Previous studies have revealed that TIPE1 serves as a tumor suppressor gene in several tumor types. However, we demonstrated that TIPE1 can promote cervical cancer proliferation by suppressing p53 activity. Here, we showed that TIPE1 inhibits cervical cancer cell apoptosis both in vivo and in vitro. Mechanistically, we revealed that TIPE1 facilitates chemoresistance in a wild-type p53-dependent manner. The results indicated that TIPE1 is responsible for the transition from chemosensitivity to chemoresistance, and that it can serve as a promising target in cervical cancer chemotherapy.
format Online
Article
Text
id pubmed-7843385
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-78433852021-01-30 TIPE1 Promotes Cervical Cancer Cell Chemoresistance to Cisplatin in a Wild-Type p53-Dependent Manner Jiang, Jie Gao, Li Lan, Yongting Wang, Yang Zhao, Peiqing Front Oncol Oncology Previous studies have revealed that TIPE1 serves as a tumor suppressor gene in several tumor types. However, we demonstrated that TIPE1 can promote cervical cancer proliferation by suppressing p53 activity. Here, we showed that TIPE1 inhibits cervical cancer cell apoptosis both in vivo and in vitro. Mechanistically, we revealed that TIPE1 facilitates chemoresistance in a wild-type p53-dependent manner. The results indicated that TIPE1 is responsible for the transition from chemosensitivity to chemoresistance, and that it can serve as a promising target in cervical cancer chemotherapy. Frontiers Media S.A. 2021-01-15 /pmc/articles/PMC7843385/ /pubmed/33520705 http://dx.doi.org/10.3389/fonc.2020.593615 Text en Copyright © 2021 Jiang, Gao, Lan, Wang and Zhao http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Jiang, Jie
Gao, Li
Lan, Yongting
Wang, Yang
Zhao, Peiqing
TIPE1 Promotes Cervical Cancer Cell Chemoresistance to Cisplatin in a Wild-Type p53-Dependent Manner
title TIPE1 Promotes Cervical Cancer Cell Chemoresistance to Cisplatin in a Wild-Type p53-Dependent Manner
title_full TIPE1 Promotes Cervical Cancer Cell Chemoresistance to Cisplatin in a Wild-Type p53-Dependent Manner
title_fullStr TIPE1 Promotes Cervical Cancer Cell Chemoresistance to Cisplatin in a Wild-Type p53-Dependent Manner
title_full_unstemmed TIPE1 Promotes Cervical Cancer Cell Chemoresistance to Cisplatin in a Wild-Type p53-Dependent Manner
title_short TIPE1 Promotes Cervical Cancer Cell Chemoresistance to Cisplatin in a Wild-Type p53-Dependent Manner
title_sort tipe1 promotes cervical cancer cell chemoresistance to cisplatin in a wild-type p53-dependent manner
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7843385/
https://www.ncbi.nlm.nih.gov/pubmed/33520705
http://dx.doi.org/10.3389/fonc.2020.593615
work_keys_str_mv AT jiangjie tipe1promotescervicalcancercellchemoresistancetocisplatininawildtypep53dependentmanner
AT gaoli tipe1promotescervicalcancercellchemoresistancetocisplatininawildtypep53dependentmanner
AT lanyongting tipe1promotescervicalcancercellchemoresistancetocisplatininawildtypep53dependentmanner
AT wangyang tipe1promotescervicalcancercellchemoresistancetocisplatininawildtypep53dependentmanner
AT zhaopeiqing tipe1promotescervicalcancercellchemoresistancetocisplatininawildtypep53dependentmanner

Ejemplares similares