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Second primary malignancies of eye and ocular adnexa after a first primary elsewhere in the body

PURPOSE: The eye and its adnexal structures can give rise to first or consecutive primary malignancies or to encounter metastasis. Our aim was to define the characteristics of the second primary neoplasms affecting the eye and its adnexa and find the risk modifying factors for them after malignancie...

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Autores principales: Alfaar, Ahmad Samir, Saad, Anas M., KhalafAllah, Mahmoud Tawfik, Elsherif, Omneya Ezzat, Osman, Moataz Hamed, Strauß, Olaf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7843581/
https://www.ncbi.nlm.nih.gov/pubmed/32870371
http://dx.doi.org/10.1007/s00417-020-04896-1
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author Alfaar, Ahmad Samir
Saad, Anas M.
KhalafAllah, Mahmoud Tawfik
Elsherif, Omneya Ezzat
Osman, Moataz Hamed
Strauß, Olaf
author_facet Alfaar, Ahmad Samir
Saad, Anas M.
KhalafAllah, Mahmoud Tawfik
Elsherif, Omneya Ezzat
Osman, Moataz Hamed
Strauß, Olaf
author_sort Alfaar, Ahmad Samir
collection PubMed
description PURPOSE: The eye and its adnexal structures can give rise to first or consecutive primary malignancies or to encounter metastasis. Our aim was to define the characteristics of the second primary neoplasms affecting the eye and its adnexa and find the risk modifying factors for them after malignancies elsewhere in the body. METHODS: We have queried the Surveillance, Epidemiology and End-Results “SEER”-9 program of the National Cancer Institute for the malignancies of the eye and its adnexa that occurred between 1973 and 2015. The malignancies were ordered chronologically according to their incidence: first or second primary malignancies. The tumors were classified according to ICD-O-3 classification. Standardized incidence ratios (SIR) and survival probabilities were calculated for subgroups. RESULTS: Among 3,578,950 cancer patients, 1203 experienced a second malignancies of the eye and its adnexa. The first malignancy was diagnosed between 50 and 69 years of age in 58.94% of them. The eyelid showed 280 events, while 50 in lacrimal gland, 181 in the orbit, 21 in the overlapping lesions, 15 in optic nerve, 148 in the conjunctiva, 9 in the cornea, 6 in the Retina, 379 in the choroid, and 93 in the ciliary body. The SIR of a second malignancy after a prior non-Hodgkin lymphoma was 2.42, and in case of previous skin carcinomas it was 3.02, melanoma of skin, and 2.13 and 1.58 in oral cavity/pharynx malignancies. The second ocular and adnexal neoplasms increased steadily over the 5-year periods on contrary to first primary neoplasms. The survival of patients affected with first ocular and adnexal neoplasms was significantly higher than those with second ocular and adnexal neoplasms. On the other side, second primary ocular and adnexal tumors showed a better survival than second primary malignancies elsewhere. CONCLUSIONS: The epidemiological differences between first and second ocular and adnexal primaries suggest different underlying mechanisms. Careful ocular examination should be integrated in the long-term follow-up plan of cancer patients. Special attention should be given to patients with non-Hodgkin’s lymphoma and melanoma as first primary. [Image: see text] ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00417-020-04896-1) contains supplementary material, which is available to authorized users.
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spelling pubmed-78435812021-02-04 Second primary malignancies of eye and ocular adnexa after a first primary elsewhere in the body Alfaar, Ahmad Samir Saad, Anas M. KhalafAllah, Mahmoud Tawfik Elsherif, Omneya Ezzat Osman, Moataz Hamed Strauß, Olaf Graefes Arch Clin Exp Ophthalmol Oncology PURPOSE: The eye and its adnexal structures can give rise to first or consecutive primary malignancies or to encounter metastasis. Our aim was to define the characteristics of the second primary neoplasms affecting the eye and its adnexa and find the risk modifying factors for them after malignancies elsewhere in the body. METHODS: We have queried the Surveillance, Epidemiology and End-Results “SEER”-9 program of the National Cancer Institute for the malignancies of the eye and its adnexa that occurred between 1973 and 2015. The malignancies were ordered chronologically according to their incidence: first or second primary malignancies. The tumors were classified according to ICD-O-3 classification. Standardized incidence ratios (SIR) and survival probabilities were calculated for subgroups. RESULTS: Among 3,578,950 cancer patients, 1203 experienced a second malignancies of the eye and its adnexa. The first malignancy was diagnosed between 50 and 69 years of age in 58.94% of them. The eyelid showed 280 events, while 50 in lacrimal gland, 181 in the orbit, 21 in the overlapping lesions, 15 in optic nerve, 148 in the conjunctiva, 9 in the cornea, 6 in the Retina, 379 in the choroid, and 93 in the ciliary body. The SIR of a second malignancy after a prior non-Hodgkin lymphoma was 2.42, and in case of previous skin carcinomas it was 3.02, melanoma of skin, and 2.13 and 1.58 in oral cavity/pharynx malignancies. The second ocular and adnexal neoplasms increased steadily over the 5-year periods on contrary to first primary neoplasms. The survival of patients affected with first ocular and adnexal neoplasms was significantly higher than those with second ocular and adnexal neoplasms. On the other side, second primary ocular and adnexal tumors showed a better survival than second primary malignancies elsewhere. CONCLUSIONS: The epidemiological differences between first and second ocular and adnexal primaries suggest different underlying mechanisms. Careful ocular examination should be integrated in the long-term follow-up plan of cancer patients. Special attention should be given to patients with non-Hodgkin’s lymphoma and melanoma as first primary. [Image: see text] ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00417-020-04896-1) contains supplementary material, which is available to authorized users. Springer Berlin Heidelberg 2020-09-01 2021 /pmc/articles/PMC7843581/ /pubmed/32870371 http://dx.doi.org/10.1007/s00417-020-04896-1 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Oncology
Alfaar, Ahmad Samir
Saad, Anas M.
KhalafAllah, Mahmoud Tawfik
Elsherif, Omneya Ezzat
Osman, Moataz Hamed
Strauß, Olaf
Second primary malignancies of eye and ocular adnexa after a first primary elsewhere in the body
title Second primary malignancies of eye and ocular adnexa after a first primary elsewhere in the body
title_full Second primary malignancies of eye and ocular adnexa after a first primary elsewhere in the body
title_fullStr Second primary malignancies of eye and ocular adnexa after a first primary elsewhere in the body
title_full_unstemmed Second primary malignancies of eye and ocular adnexa after a first primary elsewhere in the body
title_short Second primary malignancies of eye and ocular adnexa after a first primary elsewhere in the body
title_sort second primary malignancies of eye and ocular adnexa after a first primary elsewhere in the body
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7843581/
https://www.ncbi.nlm.nih.gov/pubmed/32870371
http://dx.doi.org/10.1007/s00417-020-04896-1
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