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Proliferative polyploid cells give rise to tumors via ploidy reduction

Polyploidy is a hallmark of cancer, and closely related to chromosomal instability involved in cancer progression. Importantly, polyploid cells also exist in some normal tissues. Polyploid hepatocytes proliferate and dynamically reduce their ploidy during liver regeneration. This raises the question...

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Detalles Bibliográficos
Autores principales:	Matsumoto, Tomonori, Wakefield, Leslie, Peters, Alexander, Peto, Myron, Spellman, Paul, Grompe, Markus
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7843634/ https://www.ncbi.nlm.nih.gov/pubmed/33510149 http://dx.doi.org/10.1038/s41467-021-20916-y

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