Missense Variants in PAX4 Are Associated with Early-Onset Diabetes in Chinese

INTRODUCTION: East Asians are more susceptible to early-onset diabetes than Europeans and exhibit reduced insulin secretion at earlier stages. PAX4 plays a critical role in the development of β-cells. The dysfunction-missense variants PAX4 R192H and PAX4 R192S are common in East Asians but rare in E...

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Detalles Bibliográficos
Autores principales: Gao, Aibo, Gu, Bin, Zhang, Juan, Fang, Chen, Su, Junlei, Li, Haorong, Han, Rulai, Ye, Lei, Wang, Weiqing, Ning, Guang, Wang, Jiqiu, Gu, Weiqiong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Healthcare 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7843779/
https://www.ncbi.nlm.nih.gov/pubmed/33216280
http://dx.doi.org/10.1007/s13300-020-00960-5

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