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Scarred Lung. An Update on Radiation-Induced Pulmonary Fibrosis
Radiation-induced pulmonary fibrosis is a common severe long-time complication of radiation therapy for tumors of the thorax. Current therapeutic options used in the clinic include only supportive managements strategies, such as anti-inflammatory treatment using steroids, their efficacy, however, is...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7843914/ https://www.ncbi.nlm.nih.gov/pubmed/33521012 http://dx.doi.org/10.3389/fmed.2020.585756 |
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author | Jarzebska, Natalia Karetnikova, Ekaterina S. Markov, Alexander G. Kasper, Michael Rodionov, Roman N. Spieth, Peter M. |
author_facet | Jarzebska, Natalia Karetnikova, Ekaterina S. Markov, Alexander G. Kasper, Michael Rodionov, Roman N. Spieth, Peter M. |
author_sort | Jarzebska, Natalia |
collection | PubMed |
description | Radiation-induced pulmonary fibrosis is a common severe long-time complication of radiation therapy for tumors of the thorax. Current therapeutic options used in the clinic include only supportive managements strategies, such as anti-inflammatory treatment using steroids, their efficacy, however, is far from being satisfactory. Recent studies have demonstrated that the development of lung fibrosis is a dynamic and complex process, involving the release of reactive oxygen species, activation of Toll-like receptors, recruitment of inflammatory cells, excessive production of nitric oxide and production of collagen by activated myofibroblasts. In this review we summarized the current state of knowledge on the pathophysiological processes leading to the development of lung fibrosis and we also discussed the possible treatment options. |
format | Online Article Text |
id | pubmed-7843914 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-78439142021-01-30 Scarred Lung. An Update on Radiation-Induced Pulmonary Fibrosis Jarzebska, Natalia Karetnikova, Ekaterina S. Markov, Alexander G. Kasper, Michael Rodionov, Roman N. Spieth, Peter M. Front Med (Lausanne) Medicine Radiation-induced pulmonary fibrosis is a common severe long-time complication of radiation therapy for tumors of the thorax. Current therapeutic options used in the clinic include only supportive managements strategies, such as anti-inflammatory treatment using steroids, their efficacy, however, is far from being satisfactory. Recent studies have demonstrated that the development of lung fibrosis is a dynamic and complex process, involving the release of reactive oxygen species, activation of Toll-like receptors, recruitment of inflammatory cells, excessive production of nitric oxide and production of collagen by activated myofibroblasts. In this review we summarized the current state of knowledge on the pathophysiological processes leading to the development of lung fibrosis and we also discussed the possible treatment options. Frontiers Media S.A. 2021-01-15 /pmc/articles/PMC7843914/ /pubmed/33521012 http://dx.doi.org/10.3389/fmed.2020.585756 Text en Copyright © 2021 Jarzebska, Karetnikova, Markov, Kasper, Rodionov and Spieth. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Medicine Jarzebska, Natalia Karetnikova, Ekaterina S. Markov, Alexander G. Kasper, Michael Rodionov, Roman N. Spieth, Peter M. Scarred Lung. An Update on Radiation-Induced Pulmonary Fibrosis |
title | Scarred Lung. An Update on Radiation-Induced Pulmonary Fibrosis |
title_full | Scarred Lung. An Update on Radiation-Induced Pulmonary Fibrosis |
title_fullStr | Scarred Lung. An Update on Radiation-Induced Pulmonary Fibrosis |
title_full_unstemmed | Scarred Lung. An Update on Radiation-Induced Pulmonary Fibrosis |
title_short | Scarred Lung. An Update on Radiation-Induced Pulmonary Fibrosis |
title_sort | scarred lung. an update on radiation-induced pulmonary fibrosis |
topic | Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7843914/ https://www.ncbi.nlm.nih.gov/pubmed/33521012 http://dx.doi.org/10.3389/fmed.2020.585756 |
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