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Scarred Lung. An Update on Radiation-Induced Pulmonary Fibrosis

Radiation-induced pulmonary fibrosis is a common severe long-time complication of radiation therapy for tumors of the thorax. Current therapeutic options used in the clinic include only supportive managements strategies, such as anti-inflammatory treatment using steroids, their efficacy, however, is...

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Detalles Bibliográficos
Autores principales: Jarzebska, Natalia, Karetnikova, Ekaterina S., Markov, Alexander G., Kasper, Michael, Rodionov, Roman N., Spieth, Peter M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7843914/
https://www.ncbi.nlm.nih.gov/pubmed/33521012
http://dx.doi.org/10.3389/fmed.2020.585756
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author Jarzebska, Natalia
Karetnikova, Ekaterina S.
Markov, Alexander G.
Kasper, Michael
Rodionov, Roman N.
Spieth, Peter M.
author_facet Jarzebska, Natalia
Karetnikova, Ekaterina S.
Markov, Alexander G.
Kasper, Michael
Rodionov, Roman N.
Spieth, Peter M.
author_sort Jarzebska, Natalia
collection PubMed
description Radiation-induced pulmonary fibrosis is a common severe long-time complication of radiation therapy for tumors of the thorax. Current therapeutic options used in the clinic include only supportive managements strategies, such as anti-inflammatory treatment using steroids, their efficacy, however, is far from being satisfactory. Recent studies have demonstrated that the development of lung fibrosis is a dynamic and complex process, involving the release of reactive oxygen species, activation of Toll-like receptors, recruitment of inflammatory cells, excessive production of nitric oxide and production of collagen by activated myofibroblasts. In this review we summarized the current state of knowledge on the pathophysiological processes leading to the development of lung fibrosis and we also discussed the possible treatment options.
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spelling pubmed-78439142021-01-30 Scarred Lung. An Update on Radiation-Induced Pulmonary Fibrosis Jarzebska, Natalia Karetnikova, Ekaterina S. Markov, Alexander G. Kasper, Michael Rodionov, Roman N. Spieth, Peter M. Front Med (Lausanne) Medicine Radiation-induced pulmonary fibrosis is a common severe long-time complication of radiation therapy for tumors of the thorax. Current therapeutic options used in the clinic include only supportive managements strategies, such as anti-inflammatory treatment using steroids, their efficacy, however, is far from being satisfactory. Recent studies have demonstrated that the development of lung fibrosis is a dynamic and complex process, involving the release of reactive oxygen species, activation of Toll-like receptors, recruitment of inflammatory cells, excessive production of nitric oxide and production of collagen by activated myofibroblasts. In this review we summarized the current state of knowledge on the pathophysiological processes leading to the development of lung fibrosis and we also discussed the possible treatment options. Frontiers Media S.A. 2021-01-15 /pmc/articles/PMC7843914/ /pubmed/33521012 http://dx.doi.org/10.3389/fmed.2020.585756 Text en Copyright © 2021 Jarzebska, Karetnikova, Markov, Kasper, Rodionov and Spieth. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Jarzebska, Natalia
Karetnikova, Ekaterina S.
Markov, Alexander G.
Kasper, Michael
Rodionov, Roman N.
Spieth, Peter M.
Scarred Lung. An Update on Radiation-Induced Pulmonary Fibrosis
title Scarred Lung. An Update on Radiation-Induced Pulmonary Fibrosis
title_full Scarred Lung. An Update on Radiation-Induced Pulmonary Fibrosis
title_fullStr Scarred Lung. An Update on Radiation-Induced Pulmonary Fibrosis
title_full_unstemmed Scarred Lung. An Update on Radiation-Induced Pulmonary Fibrosis
title_short Scarred Lung. An Update on Radiation-Induced Pulmonary Fibrosis
title_sort scarred lung. an update on radiation-induced pulmonary fibrosis
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7843914/
https://www.ncbi.nlm.nih.gov/pubmed/33521012
http://dx.doi.org/10.3389/fmed.2020.585756
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