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Oral absorption and drug interaction kinetics of moxifloxacin in an animal model of weightlessness

To investigate the effect of simulated weightlessness on the pharmacokinetics of orally administered moxifloxacin and the antacid Maalox or the antidiarrheal Pepto-Bismol using a tail-suspended (TS) rat model of microgravity. Fasted control and TS, jugular-vein-cannulated, male Sprague-Dawley rats r...

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Autores principales: Liang, Dong, Ma, Jing, Wei, Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7843972/
https://www.ncbi.nlm.nih.gov/pubmed/33510326
http://dx.doi.org/10.1038/s41598-021-82044-3
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author Liang, Dong
Ma, Jing
Wei, Bo
author_facet Liang, Dong
Ma, Jing
Wei, Bo
author_sort Liang, Dong
collection PubMed
description To investigate the effect of simulated weightlessness on the pharmacokinetics of orally administered moxifloxacin and the antacid Maalox or the antidiarrheal Pepto-Bismol using a tail-suspended (TS) rat model of microgravity. Fasted control and TS, jugular-vein-cannulated, male Sprague-Dawley rats received either a single 5 mg/kg intravenous dose or a single 10 mg/kg oral dose of moxifloxacin alone or with a 0.625 mL/kg oral dose of Maalox or a 1.43 mL/kg oral dose of Pepto-Bismol. Plasma concentrations of moxifloxacin were measured by HPLC. Pharmacokinetic data were analyzed using WinNonlin. Simulated weightlessness had no effect on moxifloxacin disposition after intravenous administration but significantly decreased the extent of moxifloxacin oral absorption. The coadministration of moxifloxacin with Maalox to either control or TS rats caused significant reductions in the rate and extent of moxifloxacin absorption. In contrast, the coadministration of moxifloxacin with Pepto-Bismol to TS rats had no significant effect on either the rate or the extent of moxifloxacin absorption. These interactions showed dose staggering when oral administrations of Pepto-Bismol and moxifloxacin were separated by 60 min in control rats but not in TS rats. Dose staggering was more apparent after the coadministration of Maalox and moxifloxacin in TS rats.
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spelling pubmed-78439722021-01-29 Oral absorption and drug interaction kinetics of moxifloxacin in an animal model of weightlessness Liang, Dong Ma, Jing Wei, Bo Sci Rep Article To investigate the effect of simulated weightlessness on the pharmacokinetics of orally administered moxifloxacin and the antacid Maalox or the antidiarrheal Pepto-Bismol using a tail-suspended (TS) rat model of microgravity. Fasted control and TS, jugular-vein-cannulated, male Sprague-Dawley rats received either a single 5 mg/kg intravenous dose or a single 10 mg/kg oral dose of moxifloxacin alone or with a 0.625 mL/kg oral dose of Maalox or a 1.43 mL/kg oral dose of Pepto-Bismol. Plasma concentrations of moxifloxacin were measured by HPLC. Pharmacokinetic data were analyzed using WinNonlin. Simulated weightlessness had no effect on moxifloxacin disposition after intravenous administration but significantly decreased the extent of moxifloxacin oral absorption. The coadministration of moxifloxacin with Maalox to either control or TS rats caused significant reductions in the rate and extent of moxifloxacin absorption. In contrast, the coadministration of moxifloxacin with Pepto-Bismol to TS rats had no significant effect on either the rate or the extent of moxifloxacin absorption. These interactions showed dose staggering when oral administrations of Pepto-Bismol and moxifloxacin were separated by 60 min in control rats but not in TS rats. Dose staggering was more apparent after the coadministration of Maalox and moxifloxacin in TS rats. Nature Publishing Group UK 2021-01-28 /pmc/articles/PMC7843972/ /pubmed/33510326 http://dx.doi.org/10.1038/s41598-021-82044-3 Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Liang, Dong
Ma, Jing
Wei, Bo
Oral absorption and drug interaction kinetics of moxifloxacin in an animal model of weightlessness
title Oral absorption and drug interaction kinetics of moxifloxacin in an animal model of weightlessness
title_full Oral absorption and drug interaction kinetics of moxifloxacin in an animal model of weightlessness
title_fullStr Oral absorption and drug interaction kinetics of moxifloxacin in an animal model of weightlessness
title_full_unstemmed Oral absorption and drug interaction kinetics of moxifloxacin in an animal model of weightlessness
title_short Oral absorption and drug interaction kinetics of moxifloxacin in an animal model of weightlessness
title_sort oral absorption and drug interaction kinetics of moxifloxacin in an animal model of weightlessness
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7843972/
https://www.ncbi.nlm.nih.gov/pubmed/33510326
http://dx.doi.org/10.1038/s41598-021-82044-3
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