Oxycodone self-administration activates the mitogen-activated protein kinase/ mitogen- and stress-activated protein kinase (MAPK-MSK) signaling pathway in the rat dorsal striatum

To identify signaling pathways activated by oxycodone self-administration (SA), Sprague–Dawley rats self-administered oxycodone for 20 days using short—(ShA, 3 h) and long-access (LgA, 9 h) paradigms. Animals were euthanized 2 h after SA cessation and dorsal striata were used in post-mortem molecula...

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Detalles Bibliográficos
Autores principales: Blackwood, Christopher A., McCoy, Michael T., Ladenheim, Bruce, Cadet, Jean Lud
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7843984/
https://www.ncbi.nlm.nih.gov/pubmed/33510349
http://dx.doi.org/10.1038/s41598-021-82206-3

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