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Transdermal electroosmotic flow generated by a porous microneedle array patch
A microneedle array is an attractive option for a minimally invasive means to break through the skin barrier for efficient transdermal drug delivery. Here, we report the applications of solid polymer-based ion-conductive porous microneedles (PMN) containing interconnected micropores for improving io...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7843990/ https://www.ncbi.nlm.nih.gov/pubmed/33510169 http://dx.doi.org/10.1038/s41467-021-20948-4 |
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author | Kusama, Shinya Sato, Kaito Matsui, Yuuya Kimura, Natsumi Abe, Hiroya Yoshida, Shotaro Nishizawa, Matsuhiko |
author_facet | Kusama, Shinya Sato, Kaito Matsui, Yuuya Kimura, Natsumi Abe, Hiroya Yoshida, Shotaro Nishizawa, Matsuhiko |
author_sort | Kusama, Shinya |
collection | PubMed |
description | A microneedle array is an attractive option for a minimally invasive means to break through the skin barrier for efficient transdermal drug delivery. Here, we report the applications of solid polymer-based ion-conductive porous microneedles (PMN) containing interconnected micropores for improving iontophoresis, which is a technique of enhancing transdermal molecular transport by a direct current through the skin. The PMN modified with a charged hydrogel brings three innovative advantages in iontophoresis at once: (1) lowering the transdermal resistance by low-invasive puncture of the highly resistive stratum corneum, (2) transporting of larger molecules through the interconnected micropores, and (3) generating electroosmotic flow (EOF). In particular, the PMN-generated EOF greatly enhances the transdermal molecular penetration or extraction, similarly to the flow induced by external pressure. The enhanced efficiencies of the EOF-assisted delivery of a model drug (dextran) and of the extraction of glucose are demonstrated using a pig skin sample. Furthermore, the powering of the PMN-based transdermal EOF system by a built-in enzymatic biobattery (fructose / O(2) battery) is also demonstrated as a possible totally organic iontophoresis patch. |
format | Online Article Text |
id | pubmed-7843990 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-78439902021-02-08 Transdermal electroosmotic flow generated by a porous microneedle array patch Kusama, Shinya Sato, Kaito Matsui, Yuuya Kimura, Natsumi Abe, Hiroya Yoshida, Shotaro Nishizawa, Matsuhiko Nat Commun Article A microneedle array is an attractive option for a minimally invasive means to break through the skin barrier for efficient transdermal drug delivery. Here, we report the applications of solid polymer-based ion-conductive porous microneedles (PMN) containing interconnected micropores for improving iontophoresis, which is a technique of enhancing transdermal molecular transport by a direct current through the skin. The PMN modified with a charged hydrogel brings three innovative advantages in iontophoresis at once: (1) lowering the transdermal resistance by low-invasive puncture of the highly resistive stratum corneum, (2) transporting of larger molecules through the interconnected micropores, and (3) generating electroosmotic flow (EOF). In particular, the PMN-generated EOF greatly enhances the transdermal molecular penetration or extraction, similarly to the flow induced by external pressure. The enhanced efficiencies of the EOF-assisted delivery of a model drug (dextran) and of the extraction of glucose are demonstrated using a pig skin sample. Furthermore, the powering of the PMN-based transdermal EOF system by a built-in enzymatic biobattery (fructose / O(2) battery) is also demonstrated as a possible totally organic iontophoresis patch. Nature Publishing Group UK 2021-01-28 /pmc/articles/PMC7843990/ /pubmed/33510169 http://dx.doi.org/10.1038/s41467-021-20948-4 Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Kusama, Shinya Sato, Kaito Matsui, Yuuya Kimura, Natsumi Abe, Hiroya Yoshida, Shotaro Nishizawa, Matsuhiko Transdermal electroosmotic flow generated by a porous microneedle array patch |
title | Transdermal electroosmotic flow generated by a porous microneedle array patch |
title_full | Transdermal electroosmotic flow generated by a porous microneedle array patch |
title_fullStr | Transdermal electroosmotic flow generated by a porous microneedle array patch |
title_full_unstemmed | Transdermal electroosmotic flow generated by a porous microneedle array patch |
title_short | Transdermal electroosmotic flow generated by a porous microneedle array patch |
title_sort | transdermal electroosmotic flow generated by a porous microneedle array patch |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7843990/ https://www.ncbi.nlm.nih.gov/pubmed/33510169 http://dx.doi.org/10.1038/s41467-021-20948-4 |
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