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Valerian and valeric acid inhibit growth of breast cancer cells possibly by mediating epigenetic modifications

Valerian root (Valeriana officinalis) is a popular and widely available herbal supplement used to treat sleeping disorders and insomnia. The herb’s ability to ameliorate sleep dysfunction may signify an unexplored anti-tumorigenic effect due to the connection between circadian factors and tumorigene...

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Autores principales: Shi, Fengqin, Li, Ya, Han, Rui, Fu, Alan, Wang, Ronghua, Nusbaum, Olivia, Qin, Qin, Chen, Xinyi, Hou, Li, Zhu, Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7844014/
https://www.ncbi.nlm.nih.gov/pubmed/33510252
http://dx.doi.org/10.1038/s41598-021-81620-x
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author Shi, Fengqin
Li, Ya
Han, Rui
Fu, Alan
Wang, Ronghua
Nusbaum, Olivia
Qin, Qin
Chen, Xinyi
Hou, Li
Zhu, Yong
author_facet Shi, Fengqin
Li, Ya
Han, Rui
Fu, Alan
Wang, Ronghua
Nusbaum, Olivia
Qin, Qin
Chen, Xinyi
Hou, Li
Zhu, Yong
author_sort Shi, Fengqin
collection PubMed
description Valerian root (Valeriana officinalis) is a popular and widely available herbal supplement used to treat sleeping disorders and insomnia. The herb’s ability to ameliorate sleep dysfunction may signify an unexplored anti-tumorigenic effect due to the connection between circadian factors and tumorigenesis. Of particular interest are the structural similarities shared between valeric acid, valerian's active chemical ingredient, and certain histone deacteylase (HDAC) inhibitors, which imply that valerian may play a role in epigenetic gene regulation. In this study, we tested the hypothesis that the circadian-related herb valerian can inhibit breast cancer cell growth and explored epigenetic changes associated with valeric acid treatment. Our results showed that aqueous valerian extract reduced growth of breast cancer cells. In addition, treatment of valeric acid was associated with decreased breast cancer cell proliferation, migration, colony formation and 3D formation in vitro in a dose- and time-dependent manner, as well as reduced HDAC activity and a global DNA hypomethylation. Overall, these findings demonstrate that valeric acid can decrease the breast cancer cell proliferation possibly by mediating epigenetic modifications such as the inhibition of histone deacetylases and alterations of DNA methylation. This study highlights a potential utility of valeric acid as a novel HDAC inhibitor and a therapeutic agent in the treatment of breast cancer.
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spelling pubmed-78440142021-01-29 Valerian and valeric acid inhibit growth of breast cancer cells possibly by mediating epigenetic modifications Shi, Fengqin Li, Ya Han, Rui Fu, Alan Wang, Ronghua Nusbaum, Olivia Qin, Qin Chen, Xinyi Hou, Li Zhu, Yong Sci Rep Article Valerian root (Valeriana officinalis) is a popular and widely available herbal supplement used to treat sleeping disorders and insomnia. The herb’s ability to ameliorate sleep dysfunction may signify an unexplored anti-tumorigenic effect due to the connection between circadian factors and tumorigenesis. Of particular interest are the structural similarities shared between valeric acid, valerian's active chemical ingredient, and certain histone deacteylase (HDAC) inhibitors, which imply that valerian may play a role in epigenetic gene regulation. In this study, we tested the hypothesis that the circadian-related herb valerian can inhibit breast cancer cell growth and explored epigenetic changes associated with valeric acid treatment. Our results showed that aqueous valerian extract reduced growth of breast cancer cells. In addition, treatment of valeric acid was associated with decreased breast cancer cell proliferation, migration, colony formation and 3D formation in vitro in a dose- and time-dependent manner, as well as reduced HDAC activity and a global DNA hypomethylation. Overall, these findings demonstrate that valeric acid can decrease the breast cancer cell proliferation possibly by mediating epigenetic modifications such as the inhibition of histone deacetylases and alterations of DNA methylation. This study highlights a potential utility of valeric acid as a novel HDAC inhibitor and a therapeutic agent in the treatment of breast cancer. Nature Publishing Group UK 2021-01-28 /pmc/articles/PMC7844014/ /pubmed/33510252 http://dx.doi.org/10.1038/s41598-021-81620-x Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Shi, Fengqin
Li, Ya
Han, Rui
Fu, Alan
Wang, Ronghua
Nusbaum, Olivia
Qin, Qin
Chen, Xinyi
Hou, Li
Zhu, Yong
Valerian and valeric acid inhibit growth of breast cancer cells possibly by mediating epigenetic modifications
title Valerian and valeric acid inhibit growth of breast cancer cells possibly by mediating epigenetic modifications
title_full Valerian and valeric acid inhibit growth of breast cancer cells possibly by mediating epigenetic modifications
title_fullStr Valerian and valeric acid inhibit growth of breast cancer cells possibly by mediating epigenetic modifications
title_full_unstemmed Valerian and valeric acid inhibit growth of breast cancer cells possibly by mediating epigenetic modifications
title_short Valerian and valeric acid inhibit growth of breast cancer cells possibly by mediating epigenetic modifications
title_sort valerian and valeric acid inhibit growth of breast cancer cells possibly by mediating epigenetic modifications
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7844014/
https://www.ncbi.nlm.nih.gov/pubmed/33510252
http://dx.doi.org/10.1038/s41598-021-81620-x
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