Metformin exerts anti-cancerogenic effects and reverses epithelial-to-mesenchymal transition trait in primary human intrahepatic cholangiocarcinoma cells

Intrahepatic cholangiocarcinoma (iCCA) is a highly aggressive cancer with marked resistance to chemotherapeutics without therapies. The tumour microenvironment of iCCA is enriched of Cancer-Stem-Cells expressing Epithelial-to-Mesenchymal Transition (EMT) traits, being these features associated with...

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Detalles Bibliográficos
Autores principales: Di Matteo, Sabina, Nevi, Lorenzo, Overi, Diletta, Landolina, Nadine, Faccioli, Jessica, Giulitti, Federico, Napoletano, Chiara, Oddi, Andrea, Marziani, Augusto M., Costantini, Daniele, De Rose, Agostino M., Melandro, Fabio, Bragazzi, Maria C., Grazi, Gian Luca, Berloco, Pasquale B., Giuliante, Felice, Donato, Giuseppe, Moretta, Lorenzo, Carpino, Guido, Cardinale, Vincenzo, Gaudio, Eugenio, Alvaro, Domenico
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7844056/
https://www.ncbi.nlm.nih.gov/pubmed/33510179
http://dx.doi.org/10.1038/s41598-021-81172-0

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