Apoptosis induced by SARS-CoV-2: can we target it?

Some viruses are known to be associated with increased apoptosis. Apoptotic cell death triggered by these viruses has a complex role in host antiviral immunity, and might facilitate the viral clearance or act as a mechanism for virus-induced tissue injury and disease progression. The induction of ap...

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Detalles Bibliográficos
Autores principales: Donia, Ahmed, Bokhari, Habib
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2021
Materias:
Letter to the Editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7844099/
https://www.ncbi.nlm.nih.gov/pubmed/33512610
http://dx.doi.org/10.1007/s10495-021-01656-2
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author Donia, Ahmed
Bokhari, Habib
author_facet Donia, Ahmed
Bokhari, Habib
author_sort Donia, Ahmed
collection PubMed
description Some viruses are known to be associated with increased apoptosis. Apoptotic cell death triggered by these viruses has a complex role in host antiviral immunity, and might facilitate the viral clearance or act as a mechanism for virus-induced tissue injury and disease progression. The induction of apoptosis is a hallmark of SARS-CoV-2 infection. Accumulating evidence suggests that there is a direct relationship between apoptosis rate and COVID‐19 pathogenicity/severity. Targeting virus-induced apoptosis could be a promising strategy in the treatment of SARS-CoV-2 virus infection.
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spelling pubmed-78440992021-01-29 Apoptosis induced by SARS-CoV-2: can we target it? Donia, Ahmed Bokhari, Habib Apoptosis Letter to the Editor Some viruses are known to be associated with increased apoptosis. Apoptotic cell death triggered by these viruses has a complex role in host antiviral immunity, and might facilitate the viral clearance or act as a mechanism for virus-induced tissue injury and disease progression. The induction of apoptosis is a hallmark of SARS-CoV-2 infection. Accumulating evidence suggests that there is a direct relationship between apoptosis rate and COVID‐19 pathogenicity/severity. Targeting virus-induced apoptosis could be a promising strategy in the treatment of SARS-CoV-2 virus infection. Springer US 2021-01-29 2021 /pmc/articles/PMC7844099/ /pubmed/33512610 http://dx.doi.org/10.1007/s10495-021-01656-2 Text en © The Author(s), under exclusive licence to Springer Science+Business Media, LLC part of Springer Nature 2021 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Letter to the Editor
Donia, Ahmed
Bokhari, Habib
Apoptosis induced by SARS-CoV-2: can we target it?
title Apoptosis induced by SARS-CoV-2: can we target it?
title_full Apoptosis induced by SARS-CoV-2: can we target it?
title_fullStr Apoptosis induced by SARS-CoV-2: can we target it?
title_full_unstemmed Apoptosis induced by SARS-CoV-2: can we target it?
title_short Apoptosis induced by SARS-CoV-2: can we target it?
title_sort apoptosis induced by sars-cov-2: can we target it?
topic Letter to the Editor
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7844099/
https://www.ncbi.nlm.nih.gov/pubmed/33512610
http://dx.doi.org/10.1007/s10495-021-01656-2
work_keys_str_mv AT doniaahmed apoptosisinducedbysarscov2canwetargetit
AT bokharihabib apoptosisinducedbysarscov2canwetargetit

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