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Mathematical modelling and analysis of COVID-19 epidemic and predicting its future situation in Ethiopia
The epidemic of the coronavirus disease 2019 (COVID-19) has been rising rapidly and life-threatening worldwide since its inception. The lack of an established vaccine for this disease has caused millions of illnesses and hundreds of thousands of deaths globally. Mathematical models have become cruci...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Author(s). Published by Elsevier B.V.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7844354/ https://www.ncbi.nlm.nih.gov/pubmed/33532177 http://dx.doi.org/10.1016/j.rinp.2021.103853 |
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author | Gebremeskel, Abadi Abay Berhe, Hailay Weldegiorgis Atsbaha, Habtu Alemayehu |
author_facet | Gebremeskel, Abadi Abay Berhe, Hailay Weldegiorgis Atsbaha, Habtu Alemayehu |
author_sort | Gebremeskel, Abadi Abay |
collection | PubMed |
description | The epidemic of the coronavirus disease 2019 (COVID-19) has been rising rapidly and life-threatening worldwide since its inception. The lack of an established vaccine for this disease has caused millions of illnesses and hundreds of thousands of deaths globally. Mathematical models have become crucial tools in determining the potential and seriousness of the disease and in helping the types of strategic intervention measures to be taken to prevent and control the intensity of the spread of the disease. In this study, a compartmental epidemic model of COVID-19 is proposed and analyzed to predict the transmission dynamics of the disease in Ethiopia. Analytically, the basic reproduction number is determined. To observe the dynamics of the system, a detailed stability analysis of the disease-free equilibrium (DFE) of the proposed model is carried out. Our result shows that the DFE is stable if the basic reproduction number is less than unity and unstable otherwise. Also, the parameters of the assumed model are estimated using the actual data of COVID-19 from Ethiopia reported for three months between March and June 2020. Furthermore, we performed a sensitivity analysis of the basic reproductive number and found that reducing the rate of transmission is the most important factor in achieving disease control. Numerical simulations demonstrate the suitability of the proposed model for the actual COVID-19 data in Ethiopia. In particular, the numerical simulation shows an increase in the rate of transmission leads to a significant increase in the infected individuals. Thus, results of the numerical simulations are in agreement with the sensitivity results of the system. The possible implication of this is that declining the rate of transmission to the desired level could enable us to combat the disease. Numerical simulations are also performed to forecast the disease prevalence in the community. |
format | Online Article Text |
id | pubmed-7844354 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | The Author(s). Published by Elsevier B.V. |
record_format | MEDLINE/PubMed |
spelling | pubmed-78443542021-01-29 Mathematical modelling and analysis of COVID-19 epidemic and predicting its future situation in Ethiopia Gebremeskel, Abadi Abay Berhe, Hailay Weldegiorgis Atsbaha, Habtu Alemayehu Results Phys Article The epidemic of the coronavirus disease 2019 (COVID-19) has been rising rapidly and life-threatening worldwide since its inception. The lack of an established vaccine for this disease has caused millions of illnesses and hundreds of thousands of deaths globally. Mathematical models have become crucial tools in determining the potential and seriousness of the disease and in helping the types of strategic intervention measures to be taken to prevent and control the intensity of the spread of the disease. In this study, a compartmental epidemic model of COVID-19 is proposed and analyzed to predict the transmission dynamics of the disease in Ethiopia. Analytically, the basic reproduction number is determined. To observe the dynamics of the system, a detailed stability analysis of the disease-free equilibrium (DFE) of the proposed model is carried out. Our result shows that the DFE is stable if the basic reproduction number is less than unity and unstable otherwise. Also, the parameters of the assumed model are estimated using the actual data of COVID-19 from Ethiopia reported for three months between March and June 2020. Furthermore, we performed a sensitivity analysis of the basic reproductive number and found that reducing the rate of transmission is the most important factor in achieving disease control. Numerical simulations demonstrate the suitability of the proposed model for the actual COVID-19 data in Ethiopia. In particular, the numerical simulation shows an increase in the rate of transmission leads to a significant increase in the infected individuals. Thus, results of the numerical simulations are in agreement with the sensitivity results of the system. The possible implication of this is that declining the rate of transmission to the desired level could enable us to combat the disease. Numerical simulations are also performed to forecast the disease prevalence in the community. The Author(s). Published by Elsevier B.V. 2021-03 2021-01-29 /pmc/articles/PMC7844354/ /pubmed/33532177 http://dx.doi.org/10.1016/j.rinp.2021.103853 Text en © 2021 The Author(s) Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Gebremeskel, Abadi Abay Berhe, Hailay Weldegiorgis Atsbaha, Habtu Alemayehu Mathematical modelling and analysis of COVID-19 epidemic and predicting its future situation in Ethiopia |
title | Mathematical modelling and analysis of COVID-19 epidemic and predicting its future situation in Ethiopia |
title_full | Mathematical modelling and analysis of COVID-19 epidemic and predicting its future situation in Ethiopia |
title_fullStr | Mathematical modelling and analysis of COVID-19 epidemic and predicting its future situation in Ethiopia |
title_full_unstemmed | Mathematical modelling and analysis of COVID-19 epidemic and predicting its future situation in Ethiopia |
title_short | Mathematical modelling and analysis of COVID-19 epidemic and predicting its future situation in Ethiopia |
title_sort | mathematical modelling and analysis of covid-19 epidemic and predicting its future situation in ethiopia |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7844354/ https://www.ncbi.nlm.nih.gov/pubmed/33532177 http://dx.doi.org/10.1016/j.rinp.2021.103853 |
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