Cargando…

Mathematical modelling and analysis of COVID-19 epidemic and predicting its future situation in Ethiopia

The epidemic of the coronavirus disease 2019 (COVID-19) has been rising rapidly and life-threatening worldwide since its inception. The lack of an established vaccine for this disease has caused millions of illnesses and hundreds of thousands of deaths globally. Mathematical models have become cruci...

Descripción completa

Detalles Bibliográficos
Autores principales: Gebremeskel, Abadi Abay, Berhe, Hailay Weldegiorgis, Atsbaha, Habtu Alemayehu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Author(s). Published by Elsevier B.V. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7844354/
https://www.ncbi.nlm.nih.gov/pubmed/33532177
http://dx.doi.org/10.1016/j.rinp.2021.103853
_version_ 1783644328223047680
author Gebremeskel, Abadi Abay
Berhe, Hailay Weldegiorgis
Atsbaha, Habtu Alemayehu
author_facet Gebremeskel, Abadi Abay
Berhe, Hailay Weldegiorgis
Atsbaha, Habtu Alemayehu
author_sort Gebremeskel, Abadi Abay
collection PubMed
description The epidemic of the coronavirus disease 2019 (COVID-19) has been rising rapidly and life-threatening worldwide since its inception. The lack of an established vaccine for this disease has caused millions of illnesses and hundreds of thousands of deaths globally. Mathematical models have become crucial tools in determining the potential and seriousness of the disease and in helping the types of strategic intervention measures to be taken to prevent and control the intensity of the spread of the disease. In this study, a compartmental epidemic model of COVID-19 is proposed and analyzed to predict the transmission dynamics of the disease in Ethiopia. Analytically, the basic reproduction number is determined. To observe the dynamics of the system, a detailed stability analysis of the disease-free equilibrium (DFE) of the proposed model is carried out. Our result shows that the DFE is stable if the basic reproduction number is less than unity and unstable otherwise. Also, the parameters of the assumed model are estimated using the actual data of COVID-19 from Ethiopia reported for three months between March and June 2020. Furthermore, we performed a sensitivity analysis of the basic reproductive number and found that reducing the rate of transmission is the most important factor in achieving disease control. Numerical simulations demonstrate the suitability of the proposed model for the actual COVID-19 data in Ethiopia. In particular, the numerical simulation shows an increase in the rate of transmission leads to a significant increase in the infected individuals. Thus, results of the numerical simulations are in agreement with the sensitivity results of the system. The possible implication of this is that declining the rate of transmission to the desired level could enable us to combat the disease. Numerical simulations are also performed to forecast the disease prevalence in the community.
format Online
Article
Text
id pubmed-7844354
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher The Author(s). Published by Elsevier B.V.
record_format MEDLINE/PubMed
spelling pubmed-78443542021-01-29 Mathematical modelling and analysis of COVID-19 epidemic and predicting its future situation in Ethiopia Gebremeskel, Abadi Abay Berhe, Hailay Weldegiorgis Atsbaha, Habtu Alemayehu Results Phys Article The epidemic of the coronavirus disease 2019 (COVID-19) has been rising rapidly and life-threatening worldwide since its inception. The lack of an established vaccine for this disease has caused millions of illnesses and hundreds of thousands of deaths globally. Mathematical models have become crucial tools in determining the potential and seriousness of the disease and in helping the types of strategic intervention measures to be taken to prevent and control the intensity of the spread of the disease. In this study, a compartmental epidemic model of COVID-19 is proposed and analyzed to predict the transmission dynamics of the disease in Ethiopia. Analytically, the basic reproduction number is determined. To observe the dynamics of the system, a detailed stability analysis of the disease-free equilibrium (DFE) of the proposed model is carried out. Our result shows that the DFE is stable if the basic reproduction number is less than unity and unstable otherwise. Also, the parameters of the assumed model are estimated using the actual data of COVID-19 from Ethiopia reported for three months between March and June 2020. Furthermore, we performed a sensitivity analysis of the basic reproductive number and found that reducing the rate of transmission is the most important factor in achieving disease control. Numerical simulations demonstrate the suitability of the proposed model for the actual COVID-19 data in Ethiopia. In particular, the numerical simulation shows an increase in the rate of transmission leads to a significant increase in the infected individuals. Thus, results of the numerical simulations are in agreement with the sensitivity results of the system. The possible implication of this is that declining the rate of transmission to the desired level could enable us to combat the disease. Numerical simulations are also performed to forecast the disease prevalence in the community. The Author(s). Published by Elsevier B.V. 2021-03 2021-01-29 /pmc/articles/PMC7844354/ /pubmed/33532177 http://dx.doi.org/10.1016/j.rinp.2021.103853 Text en © 2021 The Author(s) Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Gebremeskel, Abadi Abay
Berhe, Hailay Weldegiorgis
Atsbaha, Habtu Alemayehu
Mathematical modelling and analysis of COVID-19 epidemic and predicting its future situation in Ethiopia
title Mathematical modelling and analysis of COVID-19 epidemic and predicting its future situation in Ethiopia
title_full Mathematical modelling and analysis of COVID-19 epidemic and predicting its future situation in Ethiopia
title_fullStr Mathematical modelling and analysis of COVID-19 epidemic and predicting its future situation in Ethiopia
title_full_unstemmed Mathematical modelling and analysis of COVID-19 epidemic and predicting its future situation in Ethiopia
title_short Mathematical modelling and analysis of COVID-19 epidemic and predicting its future situation in Ethiopia
title_sort mathematical modelling and analysis of covid-19 epidemic and predicting its future situation in ethiopia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7844354/
https://www.ncbi.nlm.nih.gov/pubmed/33532177
http://dx.doi.org/10.1016/j.rinp.2021.103853
work_keys_str_mv AT gebremeskelabadiabay mathematicalmodellingandanalysisofcovid19epidemicandpredictingitsfuturesituationinethiopia
AT berhehailayweldegiorgis mathematicalmodellingandanalysisofcovid19epidemicandpredictingitsfuturesituationinethiopia
AT atsbahahabtualemayehu mathematicalmodellingandanalysisofcovid19epidemicandpredictingitsfuturesituationinethiopia